Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 2/20 | 0.41 |
| ▸ | RECQL | P46063 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | GLB1 | P16278 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CTRC | Q99895 | 1/20 | 0.41 |
| ▸ | SMAD3 | P84022 | 1/20 | 0.39 |
| ▸ | MGLL | Q99685 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29389278 | 1.00 | THRB (0.41) | THRBRECQLTDP1ALDH1A1CYP3A4 | |
| SCHEMBL29838717 | 0.85 | SMAD3 (0.35) | THRBRECQLTDP1ALDH1A1CYP3A4 | |
| SCHEMBL29838734 | 0.85 | SMAD3 (0.35) | THRBRECQLTDP1ALDH1A1CYP3A4 | |
| SCHEMBL5489541 | 0.85 | SMAD3 (0.35) | THRBRECQLTDP1ALDH1A1CYP3A4 | |
| SCHEMBL202598 | 0.82 | ALDH1A1 (0.48) | THRBRECQLTDP1ALDH1A1CYP3A4 | |
| SCHEMBL126497 | 0.80 | THRB (0.40) | THRBRECQLTDP1ALDH1A1CYP3A4 | |
| SCHEMBL5094500 | 0.77 | THRB (0.41) | THRBRECQLTDP1ALDH1A1CYP3A4 | |
| SCHEMBL6843543 | 0.76 | HPGD (0.46) | THRBRECQLTDP1ALDH1A1CYP3A4 | |
| SCHEMBL347626 | 0.74 | THRB (0.50) | THRBRECQLTDP1ALDH1A1CYP3A4 | |
| SCHEMBL204164 | 0.74 | ALDH1A1 (0.48) | THRBRECQLTDP1ALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 90 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190018018-A1 | SIGNALING CONJUGATES AND METHODS OF USE | VENTANA MED SYST INC (US) | 2019-01-17 | — | — | US | claimed |
| US-20180328932-A1 | SIGNALING CONJUGATES AND METHODS OF USE | VENTANA MED SYST INC (US) | 2018-11-15 | — | — | US | claimed |
| US-12587724-B2 | Digitally enhanced microscopy for multiplexed histology | VENTANA MEDICAL SYSTEMS, INC. (US) | 2026-03-24 | — | — | US | disclosed |
| US-12577266-B2 | Protein proximity assay in formalin fixed paraffin embedded tissue using caged haptens | VENTANA MEDICAL SYSTEMS, INC. (US) | 2026-03-17 | — | — | US | disclosed |
| US-12559511-B2 | Protein proximity assay in formalin fixed paraffin embedded tissue using caged haptens | VENTANA MEDICAL SYSTEMS, INC. (US) | 2026-02-24 | — | — | US | disclosed |
| EP-4544304-A1 | IMMUNOHISTOCHEMISTRY (IHC) PROTOCOLS AND METHODS FOR DIAGNOSING AND TREATING CANCER | Agilent Technologies, Inc. (US) | 2025-04-30 | — | — | EP | disclosed |
| US-20250106488-A1 | DIGITALLY ENHANCED MICROSCOPY FOR MULTIPLEXED HISTOLOGY | VENTANA MEDICAL SYSTEMS, INC. | 2025-03-27 | — | — | US | disclosed |
| US-20250066426-A1 | PEPTIDE NUCLEIC ACID CONJUGATES | VENTANA MED SYST INC (US) | 2025-02-27 | — | — | US | disclosed |
| US-20250066397-A1 | PROTEIN PROXIMITY ASSAY IN FORMALIN FIXED PAFFAFIN EMBEDDED TISSUE USING CAGED HAPTENS | VENTANA MED SYST INC (US) | 2025-02-27 | — | — | US | disclosed |
| US-20240426827-A1 | ANTI-HUMAN CD10 ANTIBODIES FOR USE IN IMMUNOHISTOCHEMISTRY (IHC) PROTOCOLS TO DIAGNOSE CANCER | AGILENT TECHNOLOGIES, INC. | 2024-12-26 | — | — | US | disclosed |
| US-12173019-B2 | Protein proximity assay in formalin fixed paffafin embedded tissue using caged haptens | VENTANA MEDICAL SYSTEMS, INC. (US) | 2024-12-24 | — | — | US | disclosed |
| EP-2972227-A1 | DIGITALLY ENHANCED MICROSCOPY FOR MULTIPLEXED HISTOLOGY | Ventana Medical Systems, Inc. (US) | 2016-01-20 | — | — | EP | disclosed |
| EP-2831587-A1 | SIGNALING CONJUGATES AND METHODS OF USE | Ventana Medical Systems, Inc. (US) | 2015-02-04 | — | — | EP | disclosed |
| US-20140267672-A1 | DIGITALLY ENHANCED MICROSCOPY FOR MULTIPLEXED HISTOLOGY | VENTANA MEDICAL SYSTEMS, INC. | 2014-09-18 | — | — | US | disclosed |
| WO-2014143155-A1 | DIGITALLY ENHANCED MICROSCOPY FOR MULTIPLEXED HISTOLOGY | VENTANA MEDICAL SYSTEMS, INC. (US) | 2014-09-18 | — | — | WO | disclosed |
| US-20130260379-A1 | SIGNALING CONJUGATES AND METHODS OF USE | VENTANA MEDICAL SYSTEMS, INC. (US) | 2013-10-03 | — | — | US | disclosed |
| WO-2013148498-A1 | SIGNALING CONJUGATES AND METHODS OF USE | VENTANA MEDICAL SYSTEMS, INC. (US) | 2013-10-03 | — | — | WO | disclosed |
| EP-1929309-A2 | METHOD FOR IDENTIFYING THERAPEUTICS USING BIOMARKERS RESPONSIVE TO THIAZOLIDINEDIONES | Digilab, Inc. (US) | 2008-06-11 | — | — | EP | disclosed |
| EP-1876448-A1 | Method and analytical reagents for identifying therapeutics using biomarkers responsive to thiazolidinediones. | DIGILAB BioVisioN GmbH (DE) | 2008-01-09 | — | — | EP | disclosed |
| WO-2007039184-A2 | METHOD AND ANALYTICAL REAGENTS FOR IDENTIFYING THERAPEUTICS USING BIOMARKERS RESPONSIVE TO THIAZOLIDINEDIONES | DIGILAB, INC. (US) | 2007-04-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12587724-B2 | Digitally enhanced microscopy for multiplexed histology | MAP1LC3B, MAP1LC3A, MAP1LC3C | THRB 1867/4885RECQL 2591/4885TDP1 3438/4885 |
| US-12173019-B2 | Protein proximity assay in formalin fixed paffafin embedded tissue using caged haptens | PAFAH1B2, PAFAH1B3, PAF1 | THRB 4069/4885RECQL 4496/4885TDP1 2603/4885 |
| US-12559511-B2 | Protein proximity assay in formalin fixed paraffin embedded tissue using caged haptens | PTMS, MKI67, ACP1 | THRB 1936/4885RECQL 1759/4885TDP1 3948/4885 |
| US-20250066397-A1 | PROTEIN PROXIMITY ASSAY IN FORMALIN FIXED PAFFAFIN EMBEDDED TISSUE USING CAGED HAPTENS | PAFAH1B2, PAFAH1B3, PAF1 | THRB 4069/4885RECQL 4496/4885TDP1 2603/4885 |
| US-20250066426-A1 | PEPTIDE NUCLEIC ACID CONJUGATES | PCNA, PARG, POLL | THRB 3056/4885RECQL 2583/4885TDP1 736/4885 |
| US-12577266-B2 | Protein proximity assay in formalin fixed paraffin embedded tissue using caged haptens | ACP1, AOX1, PTMS | THRB 2345/4885RECQL 2974/4885TDP1 1955/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.