SCHEMBL500769

SCHEMBL500769

COC(OC)c1c(F)cccc1Br

nearest known ligand 0.33

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
CES2 O00748 1/20 0.32
CES1 P23141 1/20 0.32
HTT P42858 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31039433 1.00 CES2 (0.32) CES2CES1HTT
SCHEMBL31614866 0.85 ALDH1A1 (0.35)
SCHEMBL5417507 0.79 KMT2A (0.32) CES2CES1
SCHEMBL12986654 0.77 CES2 (0.35) CES2CES1HTT
SCHEMBL24265371 0.76 HSD11B1 (0.32)
SCHEMBL30266772 0.74 CES2 (0.36) CES2CES1HTT
SCHEMBL2268624 0.74 CES2 (0.36) CES2CES1HTT
SCHEMBL20558458 0.73 MAOA (0.35) CES2CES1HTT
SCHEMBL6745071 0.73 CES2 (0.41) CES2CES1HTT
SCHEMBL2063057 0.73 CA2 (0.38)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 82 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025262596-A1 METHODS OF MAKING OSIVELOTOR PFIZER INC. (US) 2025-12-26 WO disclosed
US-20240358728-A1 BORON CONTAINING SMALL MOLECULES AS ANTI-INFLAMMATORY AGENTS ANACOR PHARMACEUTICALS, LLC (US) 2024-10-31 US disclosed
US-20240277848-A1 SURFACE-MODIFIED NANOPARTICLE KYOTO UNIVERSITY (JP) 2024-08-22 US disclosed
EP-3628045-B1 COMPOUNDS UNIV SHEFFIELD (GB) 2024-07-03 EP disclosed
EP-4353680-A1 SURFACE-MODIFIED NANOPARTICLE Kyoto University (JP) 2024-04-17 EP disclosed
CN-117460698-A Surface-modified nanoparticles 国立大学法人京都大学 2024-01-26 CN disclosed
US-20230008130-A1 BORON CONTAINING SMALL MOLECULES AS ANTI-INFLAMMATORY AGENTS ANACOR PHARMACEUTICALS, INC. (US) 2023-01-12 US disclosed
US-20210113534-A1 COMPOUNDS THE UNIVERSITY OF SHEFFIELD (GB) 2021-04-22 US disclosed
EP-3424932-B1 BORONOPHTHALIDES FOR THERAPEUTIC USE ANACOR PHARMACEUTICALS INC (US) 2021-04-07 EP disclosed
US-20210070780-A1 Boron-Containing Small Molecules ANACOR PHARMACEUTICALS, INC. (US) 2021-03-11 US disclosed
US-7582621-B2 Topically treating ungal and periungal infections of the nails, hoofs and claws of mammals by treating with 1-hydroxy-5-fluoro-1,3-dihydro-2,1-benzoxyborole; effectively penetrates the nail; onychomycosis; tinea unguium; fungicides; viricides; bactericides; parasiticides; yeast; microbiocides ANACOR PHARMACEUTICALS, INC. (US) 2009-09-01 US disclosed
EP-2044091-A2 COMPOUNDS FOR THE TREATMENT OF PERIODONTAL DISEASE Anacor Pharmaceuticals, Inc. (US) 2009-04-08 EP disclosed
EP-1988779-A2 BORON-CONTAINING SMALL MOLECULES AS ANTI-INFLAMMATORY AGENTS Anacor Pharmaceuticals, Inc. (US) 2008-11-12 EP disclosed
WO-2007146965-A2 COMPOUNDS FOR THE TREATMENT OF PERIODONTAL DISEASE ANACOR PHARMACEUTICALS, INC. (US) 2007-12-21 WO disclosed
US-20070293457-A1 BORON-CONTAINING SMALL MOLECULES AS ANTI-INFLAMMATORY AGENTS ANACOR PHARMACEUTICALS, LLC 2007-12-20 US disclosed
US-20070286822-A1 Compounds for the Treatment of Periodontal Disease ANACOR PHARMACEUTICALS INC. (US) 2007-12-13 US disclosed
US-20070265226-A1 Hydrolytically-Resistant Boron-Containing Therapeutics And Methods Of Use ANACOR PHARMACEUTICALS (US) 2007-11-15 US disclosed
WO-2007095638-A2 BORON-CONTAINING SMALL MOLECULES AS ANTI-INFLAMMATORY AGENTS ANACOR PHARMACEUTICALS, INC. (US) 2007-08-23 WO disclosed
US-20070155699-A1 Boron-containing small molecules ANACOR PHARMACEUTICALS (US) 2007-07-05 US disclosed
US-20060234981-A1 Boron-containing small molecules ANACOR PHARMACEUTICALS (US) 2006-10-19 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060234981-A1 Boron-containing small molecules ETF1, POLR1C, DPM1 CES2 3914/4885CES1 4650/4885HTT 1052/4885
US-20070286822-A1 Compounds for the Treatment of Periodontal Disease BPGM, HMBS, PPIP5K2 CES2 1344/4885CES1 1667/4885HTT 3735/4885
US-20230008130-A1 BORON CONTAINING SMALL MOLECULES AS ANTI-INFLAMMATORY AGENTS NFKBIA, LITAF, LRBA CES2 1824/4885CES1 2113/4885HTT 4485/4885
US-20240277848-A1 SURFACE-MODIFIED NANOPARTICLE EPCAM, CD63, CD22 CES2 1475/4885CES1 3525/4885HTT 3519/4885
US-20240358728-A1 BORON CONTAINING SMALL MOLECULES AS ANTI-INFLAMMATORY AGENTS NFKBIA, LITAF, LRBA CES2 1824/4885CES1 2113/4885HTT 4485/4885
US-20070293457-A1 BORON-CONTAINING SMALL MOLECULES AS ANTI-INFLAMMATORY AGENTS NFKBIA, LITAF, TNF CES2 1963/4885CES1 2131/4885HTT 4297/4885
US-20070155699-A1 Boron-containing small molecules ETF1, POLR1C, DPM1 CES2 3914/4885CES1 4650/4885HTT 1052/4885
US-20210113534-A1 COMPOUNDS MRGPRX2, MC2R, ADM2 CES2 1746/4885CES1 1963/4885HTT 4017/4885
US-20210070780-A1 Boron-Containing Small Molecules ETF1, POLR1C, DPM1 CES2 3914/4885CES1 4650/4885HTT 1052/4885
US-20070265226-A1 Hydrolytically-Resistant Boron-Containing Therapeutics And Methods Of Use GAA, BTD, MANBA CES2 211/4885CES1 282/4885HTT 1677/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.