Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 9/20 | 0.96 |
| ▸ | KCNN4 | O15554 | 3/20 | 0.54 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.40 |
| ▸ | DUT | P33316 | 2/20 | 0.40 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1105545 | 0.98 | KIF11 (1.00) | KIF11KCNN4TAAR1DUTCYP2A6 | |
| SCHEMBL14078204 | 0.87 | KIF11 (0.79) | KIF11KCNN4TAAR1 | |
| Acetic Acid SCHEMBL30066640 | 0.87 | KIF11 (0.79) | KIF11KCNN4TAAR1DUT | |
| SCHEMBL9617559 | 0.86 | KIF11 (0.78) | KIF11KCNN4TAAR1DUT | |
| SCHEMBL27341000 | 0.85 | KIF11 (0.77) | KIF11KCNN4TAAR1DUT | |
| SCHEMBL12264131 | 0.84 | KIF11 (0.74) | KIF11KCNN4TAAR1DUT | |
| SCHEMBL2283152 | 0.83 | KIF11 (0.74) | KIF11KCNN4DUT | |
| SCHEMBL6746344 | 0.82 | KIF11 (0.71) | KIF11KCNN4SMN1; SMN2 | |
| SCHEMBL6746389 | 0.82 | KIF11 (0.71) | KIF11KCNN4SMN1; SMN2 | |
| SCHEMBL15160759 | 0.82 | KIF11 (0.71) | KIF11KCNN4DUT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4572795-A2 | METHODS AND COMPOSITIONS FOR TREATING CANCER WITH CANCER-BINDING ADJUVANTS | The University of Chicago (US) | 2025-06-25 | — | — | EP | disclosed |
| US-20250114441-A1 | POLYMERIC VACCINE FOR OPIOID ADDICTION | THE JOHNS HOPKINS UNVERSITY | 2025-04-10 | — | — | US | disclosed |
| US-20240400684-A1 | ANTIBODY-MEDIATED DELIVERY OF CAS9 TO MAMMALIAN CELLS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2024-12-05 | — | — | US | disclosed |
| WO-2024040169-A2 | METHODS AND COMPOSITIONS FOR TREATING CANCER WITH CANCER-BINDING ADJUVANTS | THE UNIVERSITY OF CHICAGO (US) | 2024-02-22 | — | — | WO | disclosed |
| US-11484599-B2 | Polymer conjugate vaccines | THE UNIVERSITY OF CHICAGO (US) | 2022-11-01 | — | — | US | disclosed |
| CN-108770357-B | Polymer conjugate vaccines | 芝加哥大学 | 2022-10-28 | — | — | CN | disclosed |
| US-20220305135-A1 | METHODS AND COMPOSITIONS FOR TREATING CANCER WITH CANCER-TARGETED ADJUVANTS | THE UNIVERSITY OF CHICAGO (US) | 2022-09-29 | — | — | US | disclosed |
| EP-3976061-A1 | METHODS AND COMPOSITIONS FOR TREATING CANCER WITH CANCER-TARGETED ADJUVANTS | The University of Chicago (US) | 2022-04-06 | — | — | EP | disclosed |
| CN-114206355-A | Methods and compositions for treating cancer with cancer-targeting adjuvants | 芝加哥大学 | 2022-03-18 | — | — | CN | disclosed |
| US-11219697-B2 | Osteoadsorptive fluorogenic substrate of cathepsin k for imaging osteoclast activity and migration | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2022-01-11 | — | — | US | disclosed |
| US-10010619-B2 | Bipartite inhibitors of bacterial RNA polymerase | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2018-07-03 | — | — | US | disclosed |
| US-9770461-B2 | Tailored glycopolymers as anticoagulant heparin mimetics | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2017-09-26 | — | — | US | disclosed |
| US-20170056512-A1 | BIPARTITE INHIBITORS OF BACTERIAL RNA POLYMERASE | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2017-03-02 | — | — | US | disclosed |
| US-9415112-B2 | Bipartite inhibitors of bacterial RNA polymerase | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2016-08-16 | — | — | US | disclosed |
| US-20150038455-A1 | HEPARAN SULFATE/HEPARIN MIMETICS WITH ANTI-CHEMOKINE AND ANTI-INFLAMMATORY ACTIVITY | CALIFORNIA INSTITUTE OF TECHNOLOGY | 2015-02-05 | — | — | US | disclosed |
| US-20150038436-A1 | TAILORED GLYCOPOLYMERS AS ANTICOAGULANT HEPARIN MIMETICS | CALIFORNIA INSTITUTE OF TECHNOLOGY | 2015-02-05 | — | — | US | disclosed |
| US-20140206602-A1 | BIPARTITE INHIBITORS OF BACTERIAL RNA POLYMERASE | HOWARD HUGHES MEDICAL INSTITUTE | 2014-07-24 | — | — | US | disclosed |
| EP-2746378-A1 | Cleaning mixture for removing or preventing deposits from insects on surfaces | EADS Deutschland GmbH (DE) | 2014-06-25 | — | — | EP | disclosed |
| WO-2012177770-A1 | BIPARTITE INHIBITORS OF BACTERIAL RNA POLYMERASE | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2012-12-27 | — | — | WO | disclosed |
| WO-2007080109-A1 | SUBSTITUDED BENZYLOXY-PHENYLMETHYLUREA DERIVATIVES | BAYER HEALTHCARE AG (DE) | 2007-07-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140206602-A1 | BIPARTITE INHIBITORS OF BACTERIAL RNA POLYMERASE | POLR2H, POLR2E, POLM | KIF11 2398/4885KCNN4 4784/4885TAAR1 4655/4885 |
| US-20170056512-A1 | BIPARTITE INHIBITORS OF BACTERIAL RNA POLYMERASE | POLR2H, POLR2E, POLM | KIF11 2349/4885KCNN4 4769/4885TAAR1 4676/4885 |
| US-11484599-B2 | Polymer conjugate vaccines | CD14, TLR3, TLR1 | KIF11 2536/4885KCNN4 4612/4885TAAR1 604/4885 |
| US-11219697-B2 | Osteoadsorptive fluorogenic substrate of cathepsin k for imaging osteoclast activity and migration | CTSS, CTSK, CTSF | KIF11 3826/4885KCNN4 2578/4885TAAR1 3515/4885 |
| US-10010619-B2 | Bipartite inhibitors of bacterial RNA polymerase | POLR2H, POLR2E, POLM | KIF11 2349/4885KCNN4 4769/4885TAAR1 4676/4885 |
| US-20220305135-A1 | METHODS AND COMPOSITIONS FOR TREATING CANCER WITH CANCER-TARGETED ADJUVANTS | TLR3, TLR6, TLR2 | KIF11 2818/4885KCNN4 4740/4885TAAR1 607/4885 |
| US-20150038455-A1 | HEPARAN SULFATE/HEPARIN MIMETICS WITH ANTI-CHEMOKINE AND ANTI-INFLAMMATORY ACTIVITY | CCL2, CCL5, ACKR3 | KIF11 2433/4885KCNN4 4738/4885TAAR1 3825/4885 |
| US-20250114441-A1 | POLYMERIC VACCINE FOR OPIOID ADDICTION | OPRM1, OPRK1, OPRL1 | KIF11 3315/4885KCNN4 3230/4885TAAR1 76/4885 |
| US-20150038436-A1 | TAILORED GLYCOPOLYMERS AS ANTICOAGULANT HEPARIN MIMETICS | GYPA, FUT6, FUT5 | KIF11 2676/4885KCNN4 2272/4885TAAR1 4634/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.