SCHEMBL67496

SCHEMBL67496

O=S(=O)(Cl)c1cc(F)cc(F)c1

nearest known ligand 0.42

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.42
HSD17B10 Q99714 1/20 0.42
TDP1 Q9NUW8 1/20 0.42
SOS1 Q07889 1/20 0.36
CES2 O00748 1/20 0.36
CES1 P23141 1/20 0.36
CA12 O43570 1/20 0.35
CA1 P00915 1/20 0.35
CA9 Q16790 1/20 0.35
PKM P14618 1/20 0.34
KMT2A Q03164 1/20 0.34
GBA1 P04062 4/20 0.33
FEN1 P39748 2/20 0.32
EEF2K O00418 2/20 0.32
TRPV1 Q8NER1 1/20 0.31
ACLY P53396 1/20 0.31
PTGS2 P35354 1/20 0.31
HTR6 P50406 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2055456 0.85 ACLY (0.38) ALDH1A1HSD17B10TDP1ACLYHTR6
SCHEMBL17331594 0.84 ALDH1A1 (0.34) ALDH1A1HSD17B10TDP1CA1CA9
SCHEMBL22447746 0.84 FFAR4 (0.38) ALDH1A1HSD17B10TDP1FEN1PTGS2
SCHEMBL30990667 0.84 FFAR4 (0.38) ALDH1A1HSD17B10TDP1FEN1PTGS2
SCHEMBL31367742 0.84 ALDH1A1 (0.34) ALDH1A1HSD17B10TDP1CA1CA9
SCHEMBL27369528 0.82 CES2 (0.43) ALDH1A1HSD17B10TDP1SOS1CES2
SCHEMBL15576946 0.80 ALDH1A1 (0.32) ALDH1A1HSD17B10TDP1
SCHEMBL732747 0.80 CES2 (0.38) ALDH1A1HSD17B10TDP1CES2CA1
SCHEMBL24572331 0.79 ALDH1A1 (0.31) ALDH1A1HSD17B10TDP1
SCHEMBL2009173 0.79 HCAR1 (0.52) ALDH1A1HSD17B10TDP1CES2CES1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 453 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119320374-B Method for synthesizing 3-sulfonyl substituted chromone derivative by photocatalysis JIANG University OF TECHNOLOGY (CN) 2026-05-26 CN disclosed
CN-122079918-A Isoxazole biphenyl compounds with CBP BRD and BRD4 BD2 inhibitory activity, and preparation method and application thereof 2026-05-26 CN disclosed
WO-2026107425-A1 5-(PYRIDIN-4-YL)-3H-IMIDAZO[4,5-B]PYRIDINE DERIVATIVES AS CAMK2 INHIBITORS FOR THE TREATMENT OF HEART FAILURE BRISTOL-MYERS SQUIBB COMPANY (US) 2026-05-21 WO disclosed
US-12630529-B2 GCN2 modulator compounds Alesta Therapeutics BV (NL) 2026-05-19 US disclosed
US-20260014119-A1 EMOPAMIL-BINDING PROTEIN INHIBITORS AND USES THEREOF BIOGEN MA INC (US) 2026-01-15 US disclosed
US-20260001864-A1 COMPOUND CONTAINING SULFAMIDE STRUCTURE, AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF, AND PHARMACEUTICAL COMPOSITION AND APPLICATION NANJING SHUOHUI PHARMATECHNOLOGY CO., LTD (CN) 2026-01-01 US disclosed
EP-4596534-A1 NONCOVALENT SMALL-MOLECULE INHIBITORS OF THE KEAP1-NRF2 INTERACTION University of Copenhagen (DK) 2025-08-06 EP disclosed
US-20250171463-A1 EMOPAMIL-BINDING PROTEIN INHIBITORS AND USES THEREOF BIOGEN MA INC. 2025-05-29 US disclosed
EP-4554934-A1 EMOPAMIL-BINDING PROTEIN INHIBITORS AND USES THEREOF Biogen MA Inc. (US) 2025-05-21 EP disclosed
US-20250152574-A1 EMOPAMIL-BINDING PROTEIN INHIBITORS AND USES THEREOF BIOGEN MA INC. 2025-05-15 US disclosed
US-20040157823-A1 Pharmaceutical compositions containing 3-aminoazetidine derivatives, novel derivatives and their preparation AVENTIS PHARMA S.A. (FR) 2004-08-12 US disclosed
US-20040142954-A1 Heteroaryl compounds which inhibit leukocyte adhesion mediated by alpha4 integrins BIOGEN IDEC INTERNATIONAL HOLDING LTD. (BM) 2004-07-22 US disclosed
US-20040106667-A1 Substituted indazoles, compositions containing them, method of production and use AVENTIS PHARMA S.A. (FR) 2004-06-03 US disclosed
US-6734176-B2 ARE CB1-RECEPTOR ANTAGONISTS AND ARE USEFUL IN THE TREATMENT AND PREVENTION OF DISORDERS AFFECTING THE CENTRAL NERVOUS, IMMUNE, CARDIOVASCULAR OR ENDOCRINE, RESPIRATORY, GASTROINTESTINAL AND REPRODUCTIVE SYSTEMS; DRUG ABUSE AVENTIS PHARMA S.A. (FR) 2004-05-11 US disclosed
WO-2003099231-A2 HETEROARYL COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY ALPHA-4 INTEGRINS ELAN PHARMACEUTICALS, INC. (US) 2003-12-04 WO disclosed
US-20030203966-A1 Nitromethylthiobenzene derivatives as aldose reductase inhihibitors COLLONGES FRANCOIS (FR) 2003-10-30 US disclosed
US-20030119810-A1 Pharmaceutical compositions containing 3-aminoazetidine derivatives, novel derivatives and their preparation AVENTIS PHARMA S.A. (FR) 2003-06-26 US disclosed
US-6566356-B2 3-amido or 3-sulfonylamino azetidine compounds and their preparation; high affinity for cannabinoid receptor CB1 type, useful in treating central nervous system, immune, gastrointestinal or cardiovascular disorders, drug abuse AVENTIS PHARMA S.A. (FR) 2003-05-20 US disclosed
US-6509499-B1 Nervous system disorders, vision defects, diabetic retinopathy, neuropathic pain and kidney disorder treatment MERCK PATENTGESELLSCHAFT MIT (DE) 2003-01-21 US disclosed
US-20020019383-A1 Pharmaceutical compositions containing 3-aminoazetidine derivatives, novel derivatives and their preparation AVENTIS PHARMA S.A. (FR) 2002-02-14 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260014119-A1 EMOPAMIL-BINDING PROTEIN INHIBITORS AND USES THEREOF EBP, EBPL, ELP1 ALDH1A1 3608/4885HSD17B10 1820/4885TDP1 2035/4885
US-12630529-B2 GCN2 modulator compounds NR3C1, GCN1, EIF2AK4 ALDH1A1 4260/4885HSD17B10 733/4885TDP1 3878/4885
US-20040106667-A1 Substituted indazoles, compositions containing them, method of production and use ABL1, CDK3, CILK1 ALDH1A1 2583/4885HSD17B10 2868/4885TDP1 1505/4885
US-20020019383-A1 Pharmaceutical compositions containing 3-aminoazetidine derivatives, novel derivatives and their preparation HRH2, ALK, HRH1 ALDH1A1 1211/4885HSD17B10 1357/4885TDP1 2999/4885
US-20040157823-A1 Pharmaceutical compositions containing 3-aminoazetidine derivatives, novel derivatives and their preparation ALK, HRH2, HRH1 ALDH1A1 1049/4885HSD17B10 1217/4885TDP1 2031/4885
US-20030119810-A1 Pharmaceutical compositions containing 3-aminoazetidine derivatives, novel derivatives and their preparation ALK, HRH2, HRH1 ALDH1A1 1049/4885HSD17B10 1217/4885TDP1 2031/4885
US-20250171463-A1 EMOPAMIL-BINDING PROTEIN INHIBITORS AND USES THEREOF EBPL, EBP, CREBBP ALDH1A1 3076/4885HSD17B10 2354/4885TDP1 1722/4885
US-20260001864-A1 COMPOUND CONTAINING SULFAMIDE STRUCTURE, AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF, AND PHARMACEUTICAL COMPOSITION AND APPLICATION SLC10A2, SLC6A11, ABCB11 ALDH1A1 1595/4885HSD17B10 2271/4885TDP1 4802/4885
US-20040142954-A1 Heteroaryl compounds which inhibit leukocyte adhesion mediated by alpha4 integrins VCAM1, ITGB4, ITGA4 ALDH1A1 389/4885HSD17B10 1174/4885TDP1 4228/4885
US-20250152574-A1 EMOPAMIL-BINDING PROTEIN INHIBITORS AND USES THEREOF EBPL, EBP, CREBBP ALDH1A1 3089/4885HSD17B10 2379/4885TDP1 1753/4885
US-20030203966-A1 Nitromethylthiobenzene derivatives as aldose reductase inhihibitors AKR1B1, ALDOA, AKR1C1 ALDH1A1 48/4885HSD17B10 161/4885TDP1 1370/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.