Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Morpholine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 known ✓ | P00915 | 7/20 | 0.41 |
| ▸ | CA12 known ✓ | O43570 | 6/20 | 0.41 |
| ▸ | CA2 known ✓ | P00918 | 6/20 | 0.41 |
| ▸ | CA4 known ✓ | P22748 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | CA9 | Q16790 | 6/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Morpholine SCHEMBL29191392 | 0.97 | MEN1 (0.52) | MEN1KMT2AKDM4EGAACYP2C9 | |
| Morpholine SCHEMBL7987130 | 0.89 | MEN1 (0.61) | MEN1KMT2AKDM4EGAACYP2C9 | |
| Morpholine SCHEMBL497396 | 0.84 | MEN1 (0.55) | MEN1KMT2AKDM4EGAACYP2C9 | |
| Morpholine SCHEMBL10425540 | 0.82 | MEN1 (0.52) | MEN1KMT2AKDM4EGAACYP2C9 | |
| Piperazine SCHEMBL18091103 | 0.80 | HIF1A (0.43) | KDM4EGAACYP2C9CA1CA12 | |
| Morpholine SCHEMBL8009459 | 0.80 | — | — | |
| Morpholine SCHEMBL7554037 | 0.78 | MEN1 (0.61) | MEN1KMT2AKDM4EGAACYP2C9 | |
| Morpholine SCHEMBL2520893 | 0.78 | KDM4E (0.61) | MEN1KMT2AKDM4EGAACYP2C9 | |
| Piperazine SCHEMBL28520413 | 0.77 | HIF1A (0.40) | CA1CA12CA9CA2SMN1; SMN2 | |
| Morpholine SCHEMBL10379240 | 0.76 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4294576-B1 | DITHIOCARBAMATE DEPRESSANTS, METHODS AND USES THEREOF IN FROTH FLOTATION MINERAL SEPARATION | TESSENDERLO KERLEY INC (US) | 2024-12-25 | — | — | EP | disclosed |
| US-20240149277-A1 | DITHIOCARBAMATE DEPRESSANTS, METHODS AND USES THEREOF IN FROTH FLOTATION MINERAL SEPARATION | TESSENDERLO KERLEY, INC. (US) | 2024-05-09 | — | — | US | disclosed |
| CN-117861863-A | Inhibitor of non-molybdenum sulfide ore and application of inhibitor in metal sulfide ore flotation separation | 江西理工大学 | 2024-04-12 | — | — | CN | disclosed |
| EP-4294576-A1 | DITHIOCARBAMATE DEPRESSANTS, METHODS AND USES THEREOF IN FROTH FLOTATION MINERAL SEPARATION | Tessenderlo Kerley, Inc. (US) | 2023-12-27 | — | — | EP | disclosed |
| WO-2022177872-A1 | DITHIOCARBAMATE DEPRESSANTS, METHODS AND USES THEREOF IN FROTH FLOTATION MINERAL SEPARATION | TESSENDERLO KERLEY, INC. (US) | 2022-08-25 | — | — | WO | disclosed |
| US-8123982-B2 | Dithiocarbamates provide improvement over tolyltriazole in inhibiting yellow metal corrosion | AKZO NOBEL N.V. (NL) | 2012-02-28 | — | — | US | disclosed |
| US-20050211957-A1 | Sulfur based corrosion inhibitors | AKZO NOBEL N.V. (NL) | 2005-09-29 | — | — | US | disclosed |
| EP-1580301-A1 | Sulfur based corrosion inhibitors | National Starch and Chemical Investment Holding Corporation (US) | 2005-09-28 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240149277-A1 | DITHIOCARBAMATE DEPRESSANTS, METHODS AND USES THEREOF IN FROTH FLOTATION MINERAL SEPARATION | ACMSD, AP2A1, CA3 | CA1 7/4885CA12 342/4885CA2 18/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.