Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRP | O00591 | 5/20 | 0.39 |
| ▸ | GABRD | O14764 | 5/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 5/20 | 0.39 |
| ▸ | GABRB1 | P18505 | 5/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 5/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 5/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 5/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 5/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 5/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 5/20 | 0.39 |
| ▸ | GABRA4 | P48169 | 5/20 | 0.39 |
| ▸ | GABRE | P78334 | 5/20 | 0.39 |
| ▸ | GABRA6 | Q16445 | 5/20 | 0.39 |
| ▸ | GABRG1 | Q8N1C3 | 5/20 | 0.39 |
| ▸ | GABRG3 | Q99928 | 5/20 | 0.39 |
| ▸ | GABRQ | Q9UN88 | 5/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL782206 | 0.87 | L3MBTL1 (0.41) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL23781293 | 0.79 | LMNA (0.44) | LMNAKMT2AMEN1ABCC4PKM | |
| SCHEMBL28440740 | 0.78 | LMNA (0.37) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL781347 | 0.75 | GABRP (0.37) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| Hydrochloric Acid SCHEMBL28743230 | 0.73 | GABRP (0.36) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL2445825 | 0.73 | ALDH1A1 (0.61) | LMNAKMT2APKML3MBTL1ALDH1A1 | |
| SCHEMBL1407852 | 0.70 | PTGS1 (0.37) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL28579127 | 0.69 | CRHBP (0.35) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL8284977 | 0.67 | MAPK1 (0.34) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL24897834 | 0.66 | ALDH1A1 (0.40) | LMNAKMT2AMEN1TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120071628-A1 | TOPICAL THERAPEUTIC AGENT FOR OPHTHALMIC DISEASES COMPRISING COMPOUND CAPABLE OF BINDING SPECIFICALLY TO DNA SEQUENCE | NIHON UNIVERSITY (JP) | 2012-03-22 | — | — | US | disclosed |
| US-20110046070-A1 | GENE EXPRESSION INHIBITOR SELECTIVE FOR MATRIX METALLOPROTEINASE-9 GENE | NIHON UNIVERSITY (JP) | 2011-02-24 | — | — | US | disclosed |
| US-7888516-B2 | transforming growth factor (TGF- beta ) gene expression inhibitors comprising a pyrrole-imidazole polyamides, used as a therapeutic agent for diseases associated with the production of TGF- beta; drugs; side effect reduction | NIHON UNIVERSITY (JP) | 2011-02-15 | — | — | US | disclosed |
| EP-2266583-A1 | GENE EXPRESSION INHIBITOR SELECTIVE FOR MATRIX METALLOPROTEINASE-9 GENE | Nihon University (JP) | 2010-12-29 | — | — | EP | disclosed |
| US-7807844-B2 | TGF-β gene expression inhibitor | NIHON UNIVERSITY (JP) | 2010-10-05 | — | — | US | disclosed |
| US-20080255368-A1 | Tgf-ß Gene Expression Inhibitor | NIHON UNIVERSITY (JP) | 2008-10-16 | — | — | US | disclosed |
| US-20080103187-A1 | Tgf-Beta Gene Expression Inhibitor | GENTIER BIOSYSTEMS, INC. (JP) | 2008-05-01 | — | — | US | disclosed |
| EP-1779850-A1 | TGF- GENE EXPRESSION INHIBITOR | Nihon University (JP) | 2007-05-02 | — | — | EP | disclosed |
| CN-1845733-A | TGF-beta gene expression inhibitors | UNIV NIHON (JP) | 2006-10-11 | — | — | CN | disclosed |
| US-7067622-B2 | Method of the solid phase synthesis of pyrrole-imidazole polyamide | JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) | 2006-06-27 | — | — | US | disclosed |
| US-20040171799-A1 | Method of the solid phase synhesis of pyrrole-imidazole polyamide | JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) | 2004-09-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040171799-A1 | Method of the solid phase synhesis of pyrrole-imidazole polyamide | PCNA, POLH, PNISR | GABRP 172/4885GABRD 410/4885GABRA1 1125/4885 |
| US-20120071628-A1 | TOPICAL THERAPEUTIC AGENT FOR OPHTHALMIC DISEASES COMPRISING COMPOUND CAPABLE OF BINDING SPECIFICALLY TO DNA SEQUENCE | POLH, POLB, POLK | GABRP 1097/4885GABRD 1543/4885GABRA1 3477/4885 |
| US-20080255368-A1 | Tgf-ß Gene Expression Inhibitor | GABRP, GABRB2, GABRB1 | GABRP 1/4885GABRD 9/4885GABRA1 18/4885 |
| US-20110046070-A1 | GENE EXPRESSION INHIBITOR SELECTIVE FOR MATRIX METALLOPROTEINASE-9 GENE | GABRP, GABRD, MMP9 | GABRP 1/4885GABRD 2/4885GABRA1 51/4885 |
| US-20080103187-A1 | Tgf-Beta Gene Expression Inhibitor | TGFBR1, TGFBR2, SMAD2 | GABRP 158/4885GABRD 405/4885GABRA1 843/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.