Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 known ✓ | P00915 | 4/20 | 0.43 |
| ▸ | CA2 known ✓ | P00918 | 4/20 | 0.43 |
| ▸ | CA12 known ✓ | O43570 | 2/20 | 0.41 |
| ▸ | CA4 known ✓ | P22748 | 1/20 | 0.40 |
| ▸ | LIG1 | P18858 | 1/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.46 |
| ▸ | STS | P08842 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.44 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2046238 | 0.83 | LIG1 (0.49) | LIG1AKR1C3STSKMT2AGAA | |
| SCHEMBL16424564 | 0.83 | KMT2A (0.46) | AKR1C3KMT2AGAAMEN1USP2 | |
| SCHEMBL10810193 | 0.78 | THRB (0.44) | KMT2AGAAMEN1CA1CA2 | |
| SCHEMBL579429 | 0.77 | DRD2 (0.40) | AKR1C3STSKMT2AGAAMAPT | |
| SCHEMBL15795285 | 0.77 | ELANE (0.40) | AKR1C3STSKMT2AGAACA1 | |
| SCHEMBL1735933 | 0.77 | LMNA (0.50) | STSKMT2AGAAMEN1USP2 | |
| SCHEMBL9362928 | 0.76 | AKR1C3 (0.52) | AKR1C3KMT2AGAACA1CA2 | |
| SCHEMBL10789789 | 0.75 | WDR5 (0.44) | AKR1C3KMT2AGAAMEN1USP2 | |
| SCHEMBL29390505 | 0.74 | LIG1 (0.76) | LIG1AKR1C3STSKMT2AGAA | |
| SCHEMBL22129808 | 0.74 | LIG1 (0.76) | LIG1AKR1C3STSKMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2614815-B1 | FOAMABLE AEROSOL COMPOSITION | DAIZO CORP (JP) | 2019-01-16 | — | — | EP | disclosed |
| EP-2614815-A1 | FOAMABLE AEROSOL COMPOSITION | Daizo Corporation (JP) | 2013-07-17 | — | — | EP | disclosed |
| US-20130164226-A1 | FOAMABLE AEROSOL COMPOSITION | DAIZO CORPORATION (JP) | 2013-06-27 | — | — | US | disclosed |
| US-20120263769-A1 | Ultraviolet Absorber-Including Clay Mineral And Cosmetics Containing The Same | SHISEIDO COMPANY, LTD. (JP) | 2012-10-18 | — | — | US | disclosed |
| EP-2505630-A1 | CLAY MINERAL THAT INCLUDES ULTRAVIOLET ABSORBER AND COSMETICS CONTAINING SAME | Shiseido Company, Ltd. (JP) | 2012-10-03 | — | — | EP | disclosed |
| EP-0619519-A1 | Photosensitive polycondensation compound for negative lithographic plates | LASTRA S.P.A. (IT) | 1994-10-12 | — | — | EP | disclosed |