Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A known ✓ | P27815 | 1/20 | 0.49 |
| ▸ | PDE4D known ✓ | Q08499 | 1/20 | 0.49 |
| ▸ | NOD2 known ✓ | Q9HC29 | 1/20 | 0.41 |
| ▸ | CA12 known ✓ | O43570 | 2/20 | 0.36 |
| ▸ | CA1 known ✓ | P00915 | 2/20 | 0.36 |
| ▸ | CA2 known ✓ | P00918 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 6/20 | 0.50 |
| ▸ | MAPT | P10636 | 6/20 | 0.50 |
| ▸ | HTT | P42858 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | PGR | P06401 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | HRH1 | P35367 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL744481 | 0.86 | MAPT (0.54) | LMNAMAPTHTTSMN1; SMN2NPSR1 | |
| SCHEMBL16424564 | 0.81 | KMT2A (0.46) | LMNAMAPTHTTSMN1; SMN2NPSR1 | |
| SCHEMBL7767220 | 0.79 | MAPT (0.60) | LMNAMAPTHTTSMN1; SMN2NPSR1 | |
| SCHEMBL170073 | 0.78 | MAPT (0.65) | LMNAMAPTHTTSMN1; SMN2NPSR1 | |
| SCHEMBL25381912 | 0.78 | MAPT (0.64) | LMNAMAPTHTTSMN1; SMN2NPSR1 | |
| SCHEMBL489201 | 0.78 | MAPT (0.42) | LMNAMAPTHTTSMN1; SMN2NPSR1 | |
| SCHEMBL9411580 | 0.77 | LIG1 (0.46) | LMNAMAPTSMN1; SMN2ALDH1A1HPGD | |
| Sulfuric Acid SCHEMBL2878069 | 0.76 | MAPT (0.52) | LMNAMAPTHTTSMN1; SMN2NPSR1 | |
| SCHEMBL9239540 | 0.76 | LMNA (0.56) | LMNAMAPTHTTSMN1; SMN2NPSR1 | |
| SCHEMBL687665 | 0.75 | MAPT (0.59) | LMNAMAPTHTTSMN1; SMN2NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2172185-B1 | Cosmetic material comprising octyl hydroxy stearate oligomer | PARAHERMOSA CO LTD (JP) | 2011-11-23 | — | — | EP | claimed |
| CN-112352010-B | Crosslinked silicone resin, method for producing same, and cosmetic | 信越化学工业株式会社 | 2023-07-14 | — | — | CN | disclosed |
| US-10428236-B2 | Polyurethane urea resin composition exhibiting UV-absorption-agent resistance, moulded body using said composition, and coating material | TOSOH CORPORATION (JP) | 2019-10-01 | — | — | US | disclosed |
| WO-2019142921-A1 | COSMETIC COMPOSITION | 日本製紙株式会社 | 2019-07-25 | — | — | WO | disclosed |
| EP-3434330-A1 | A METHOD FOR ENHANCING THE COOLING EFFECT OF A COOLING COMPOUND | Symrise AG (DE) | 2019-01-30 | — | — | EP | disclosed |
| US-9925129-B2 | Oil-in-water emulsion cosmetic and method for producing same | JO COSMETICS CO., LTD. (JP) | 2018-03-27 | — | — | US | disclosed |
| US-20170130094-A1 | POLYURETHANE UREA RESIN COMPOSITION EXHIBITING UV-ABSORPTION-AGENT RESISTANCE, MOULDED BODY USING SAID COMPOSITION, AND COATING MATERIAL | TOSOH CORPORATION (JP) | 2017-05-11 | — | — | US | disclosed |
| US-20160081891-A1 | OIL-IN-WATER EMULSION COSMETIC AND METHOD FOR PRODUCING SAME | JO COSMETICS CO., LTD. (JP) | 2016-03-24 | — | — | US | disclosed |
| EP-2579950-A2 | USE OF POLYOLS FOR ENHANCING THE COOLING EFFECT OF A COOLING SUBSTANCE AND COOLING MIXTURES HAVING AN ENHANCED COOLING EFFECT | Symrise AG (DE) | 2013-04-17 | — | — | EP | disclosed |
| US-8198335-B2 | Cosmetic material | PARAHERMOSA CO., LTD. (JP) | 2012-06-12 | — | — | US | disclosed |
| EP-1352638-B1 | COSMETICS FOR ALLEVIATING SKIN IRRITATION | SHISEIDO CO LTD (JP) | 2009-05-20 | — | — | EP | disclosed |
| EP-1593364-B1 | Three-phase hair care composition | KPSS KAO GMBH (DE) | 2008-10-15 | — | — | EP | disclosed |
| WO-2007077259-A9 | SYNERGISTIC ACTIVE PREPARATIONS COMPRISING DIPHENYLMETHANE DERIVATIVES AND FURTHER SKIN AND/OR HAIR LIGHTENING AND/OR SENILE KERATOSIS REDUCING COMPOUNDS | SYMRISE GMBH & CO KG (DE) | 2007-09-20 | — | — | WO | disclosed |
| US-20070116654-A1 | Cosmetics | SHISEIDO CO., LTD. | 2007-05-24 | — | — | US | disclosed |
| US-7169379-B2 | Cosmetics | SHISEIDO CO., LTD. (JP) | 2007-01-30 | — | — | US | disclosed |
| US-20050249688-A1 | Hair care composition | KPSS-KAO PROFESSIONAL SALON SERVICES GMBH (DE) | 2005-11-10 | — | — | US | disclosed |
| EP-1593364-A1 | Three-phase hair care composition | KPSS-Kao Professional Salon Services GmbH (DE) | 2005-11-09 | — | — | EP | disclosed |
| US-6673756-B2 | MULTILAYER; CUTTING, JOINING UNDER PRESSURE | SYMRISE GMBH & CO. KG (DE) | 2004-01-06 | — | — | US | disclosed |
| EP-1352638-A1 | COSMETICS | SHISEIDO COMPANY, LTD. (JP) | 2003-10-15 | — | — | EP | disclosed |
| US-20020173436-A1 | Multilayer; cutting, joining under pressure | SYMRISE GMBH & CO. KG (DE) | 2002-11-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050249688-A1 | Hair care composition | KRT18, CUTA, LAGE3 | PDE4A 3416/4885PDE4D 2372/4885NOD2 4703/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.