Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 1/20 | 0.52 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.51 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | HTR2B | P41595 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | NAAA | Q02083 | 2/20 | 0.44 |
| ▸ | ASAH1 | Q13510 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11674678 | 0.84 | HAO1 (0.53) | RORCHAO1HTR2CHTR2BHDAC8 | |
| SCHEMBL2649112 | 0.84 | HAO1 (0.53) | RORCHAO1HTR2CHTR2BHDAC8 | |
| SCHEMBL7941807 | 0.82 | CA2 (0.50) | RORCHAO1HTR2CHTR2BHDAC8 | |
| SCHEMBL3289619 | 0.79 | HTT (0.55) | RORCHAO1HTR2CHTR2BLMNA | |
| SCHEMBL1089454 | 0.78 | HAO1 (0.51) | RORCHAO1HTR2CHTR2BHDAC8 | |
| SCHEMBL11674790 | 0.78 | RORC (0.52) | RORCHAO1HTR2CHTR2BHDAC8 | |
| SCHEMBL1088973 | 0.78 | HAO1 (0.51) | RORCHAO1HTR2CHTR2BHDAC8 | |
| SCHEMBL11564250 | 0.78 | RORC (0.52) | RORCHAO1HTR2CHTR2BHDAC8 | |
| SCHEMBL26089356 | 0.78 | CA2 (0.50) | RORCHAO1HDAC8HDAC6HDAC1 | |
| SCHEMBL11705183 | 0.77 | HAO1 (0.57) | RORCHAO1HDAC8HDAC6HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0340289-A4 | LIQUID IBUPROFEN COMPOSITIONS AND METHODS OF MAKING THEM | — | 1991-03-13 | — | — | EP | disclosed |
| EP-0340289-A1 | LIQUID IBUPROFEN COMPOSITIONS AND METHODS OF MAKING THEM | ORATECH PHARMACEUTICAL DEVELOPMENT CORPORATION (US) | 1989-11-08 | — | — | EP | disclosed |
| US-4861797-A | Liquid ibuprofen compositions and methods of making them | ORATECH PHARMACEUTICAL DEVELOPMENT CORPORATION (US) | 1989-08-29 | — | — | US | disclosed |
| WO-1989003210-A1 | LIQUID IBUPROFEN COMPOSITIONS AND METHODS OF MAKING THEM | ORATECH PHARMACEUTICAL DEVELOPMENT CORPORATION (US) | 1989-04-20 | — | — | WO | disclosed |