Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 1/20 | 0.56 |
| ▸ | PKM | P14618 | 2/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.49 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.47 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.46 |
| ▸ | REN | P00797 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 2/20 | 0.46 |
| ▸ | CA1 | P00915 | 2/20 | 0.46 |
| ▸ | CA2 | P00918 | 2/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.45 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.45 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.45 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25287086 | 1.00 | CNR2 (0.56) | CNR2PKMHDAC1HDAC6LIMK1 | |
| SCHEMBL21734170 | 1.00 | CNR2 (0.56) | CNR2PKMHDAC1HDAC6LIMK1 | |
| SCHEMBL20275387 | 1.00 | CNR2 (0.56) | CNR2PKMHDAC1HDAC6LIMK1 | |
| SCHEMBL31518844 | 0.99 | CNR2 (0.54) | CNR2PKMHDAC1HDAC6LIMK1 | |
| SCHEMBL28301405 | 0.94 | HDAC6 (0.54) | CNR2PKMHDAC1HDAC6LIMK1 | |
| SCHEMBL9906098 | 0.88 | LMNA (0.53) | LMNARENCA12 | |
| SCHEMBL21734171 | 0.87 | KCNH2 (0.52) | CNR2KCNH2CA12CA1CA2 | |
| SCHEMBL21734169 | 0.87 | KCNH2 (0.52) | CNR2KCNH2CA12CA1CA2 | |
| SCHEMBL28042133 | 0.85 | CNR2 (0.61) | CNR2PKMHDAC1HDAC6LIMK1 | |
| SCHEMBL15546987 | 0.85 | CNR2 (0.64) | CNR2PKMHDAC1HDAC6LIMK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 46 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11857650-B2 | Dental composition comprising a dental filler containing a structural filler and silanated glass flakes | DENTSPLY SIRONA INC. (US) | 2024-01-02 | — | — | US | disclosed |
| US-11857650-B2 | Dental composition comprising a dental filler containing a structural filler and silanated glass flakes | DENTSPLY SIRONA INC. (US) | 2024-01-02 | — | — | US | disclosed |
| EP-3518863-B1 | DENTAL COMPOSITION | DENTSPLY DETREY GMBH (DE) | 2023-11-15 | — | — | EP | disclosed |
| US-20220202658-A1 | DENTAL COMPOSITION | DENTSPLY SIRONA INC. (US) | 2022-06-30 | — | — | US | disclosed |
| US-20220031576-A1 | ADDITIVE MANUFACTURING PROCESS | DENTSPLY SIRONA INC. (US) | 2022-02-03 | — | — | US | disclosed |
| US-11224557-B2 | Dental composition | DENTSPLY SIRONA INC (US) | 2022-01-18 | — | — | US | disclosed |
| US-20220000721-A1 | BIFUNCTIONAL AND POLYFUNCTIONAL COINITIATORS IN DENTAL COMPOSITIONS | DENTSPLY SIRONA INC. (US) | 2022-01-06 | — | — | US | disclosed |
| US-11166883-B2 | Dental composition | DENTSPLY SIRONA INC. (US) | 2021-11-09 | — | — | US | disclosed |
| US-11116702-B2 | Dental composition | DENTSPLY SIRONA INC. (US) | 2021-09-14 | — | — | US | disclosed |
| US-20210106503-A1 | DENTAL IMPRESSION MATERIAL | DENTSPLY SIRONA INC. (US) | 2021-04-15 | — | — | US | disclosed |
| US-8198388-B2 | One-part self-etching, self-priming dental adhesive composition | DENTSPLY INTERNATIONAL INC. (US) | 2012-06-12 | — | — | US | disclosed |
| US-8198388-B2 | One-part self-etching, self-priming dental adhesive composition | DENTSPLY INTERNATIONAL INC. (US) | 2012-06-12 | — | — | US | disclosed |
| US-20100160485-A1 | Hydrolysis stable self-etching, self-priming adhesive | KLEE JOACHIM | 2010-06-24 | — | — | US | disclosed |
| US-20100160485-A1 | Hydrolysis stable self-etching, self-priming adhesive | KLEE JOACHIM | 2010-06-24 | — | — | US | disclosed |
| US-20100022682-A1 | Dental adhesive composition | KLEE JOACHIM E | 2010-01-28 | — | — | US | disclosed |
| US-20100022682-A1 | Dental adhesive composition | KLEE JOACHIM E | 2010-01-28 | — | — | US | disclosed |
| US-20090043008-A1 | Dental adhesive | KLEE JOACHIM E | 2009-02-12 | — | — | US | disclosed |
| US-20090043008-A1 | Dental adhesive | KLEE JOACHIM E | 2009-02-12 | — | — | US | disclosed |
| US-20070293642-A1 | One-Part Self-Etching, Self-Priming Dental Adhesive Composition | DENTSPLY DE TREY GMBH (DE) | 2007-12-20 | — | — | US | disclosed |
| US-20070293642-A1 | One-Part Self-Etching, Self-Priming Dental Adhesive Composition | DENTSPLY DE TREY GMBH (DE) | 2007-12-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11224557-B2 | Dental composition | GPX4, GPX1, NOXO1 | CNR2 4245/4885PKM 4143/4885HDAC1 912/4885 |
| US-20220202658-A1 | DENTAL COMPOSITION | CAD, PHOSPHO1, PLA2G2C | CNR2 3681/4885PKM 1519/4885HDAC1 44/4885 |
| US-20220000721-A1 | BIFUNCTIONAL AND POLYFUNCTIONAL COINITIATORS IN DENTAL COMPOSITIONS | DUOX2, DUOX1, QSOX1 | CNR2 2497/4885PKM 4003/4885HDAC1 674/4885 |
| US-20210106503-A1 | DENTAL IMPRESSION MATERIAL | FHIT, PASK, TAS2R40 | CNR2 4222/4885PKM 669/4885HDAC1 551/4885 |
| US-11857650-B2 | Dental composition comprising a dental filler containing a structural filler and silanated glass flakes | DHX35, DHX30, FLNA | CNR2 4851/4885PKM 4383/4885HDAC1 3221/4885 |
| US-11116702-B2 | Dental composition | MTR, CAD, PAM | CNR2 2236/4885PKM 2006/4885HDAC1 3761/4885 |
| US-20100160485-A1 | Hydrolysis stable self-etching, self-priming adhesive | PPA1, PHOSPHO1, PDAP1 | CNR2 4606/4885PKM 4081/4885HDAC1 1644/4885 |
| US-20070293642-A1 | One-Part Self-Etching, Self-Priming Dental Adhesive Composition | CAD, ASIC1, PDAP1 | CNR2 4776/4885PKM 4418/4885HDAC1 2108/4885 |
| US-11166883-B2 | Dental composition | MSR1, TAS2R3, TAS2R39 | CNR2 2554/4885PKM 2427/4885HDAC1 1048/4885 |
| US-20090043008-A1 | Dental adhesive | H1-0, H1-2, ITGA1 | CNR2 4590/4885PKM 4575/4885HDAC1 954/4885 |
| US-20220031576-A1 | ADDITIVE MANUFACTURING PROCESS | FLNA, FLNB, SAMM50 | CNR2 4857/4885PKM 2486/4885HDAC1 4761/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.