SCHEMBL9935989

SCHEMBL9935989

O=C(NCCO)c1ccc[nH]c1=S

nearest known ligand 0.59

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
GAA P10253 3/20 0.59
HTT P42858 4/20 0.55
ALDH1A1 P00352 3/20 0.55
APOBEC3G Q9HC16 1/20 0.55
KDM4E B2RXH2 2/20 0.54
MAPT P10636 2/20 0.54
GLS O94925 1/20 0.54
CASP1 P29466 1/20 0.45
CASP7 P55210 1/20 0.45
MEN1 O00255 1/20 0.41
CACNA1B Q00975 1/20 0.41
APBA1 Q02410 1/20 0.41
KMT2A Q03164 1/20 0.41
CHEK1 O14757 2/20 0.40
TSHR P16473 1/20 0.40
PAK4 O96013 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9936307 0.91 GAA (0.56) GAAHTTALDH1A1APOBEC3GKDM4E
SCHEMBL9935825 0.86 GAA (0.57) GAAHTTALDH1A1APOBEC3GKDM4E
SCHEMBL9937235 0.86 GAA (0.52) GAAHTTALDH1A1APOBEC3GKDM4E
SCHEMBL9936025 0.83 HTT (0.64) GAAHTTALDH1A1APOBEC3GKDM4E
SCHEMBL12062497 0.83 GAA (0.58) GAAHTTALDH1A1APOBEC3GKDM4E
SCHEMBL9936614 0.82 GAA (0.56) GAAHTTALDH1A1APOBEC3GKDM4E
SCHEMBL9936501 0.82 HTT (0.58) GAAHTTALDH1A1APOBEC3GKDM4E
SCHEMBL9936633 0.81 NAAA (0.59) GAAHTTALDH1A1APOBEC3GKDM4E
SCHEMBL9937447 0.81 ALDH1A1 (0.56) GAAHTTALDH1A1APOBEC3GKDM4E
SCHEMBL9936178 0.81 NAAA (0.59) GAAHTTALDH1A1APOBEC3GKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12521333-B2 Composition comprising compound of thiopyridinone type and polyglyceryl-based emulsifiers L'OREAL (FR) 2026-01-13 US claimed
US-20250381115-A1 STABILIZATION OF THIOPYRIDINONE COMPOUND AND COMPOSITION COMPRISING SAME OREAL (FR) 2025-12-18 US claimed
US-20250381116-A1 SOLUBILIZATION OF THIOPYRIDINONE COMPOUND AND COMPOSITION COMPRISING SAME OREAL (FR) 2025-12-18 US claimed
US-20250375367-A1 STABILIZATION OF THIOPYRIDINONE COMPOUND AND COMPOSITION COMPRISING SAME OREAL (FR) 2025-12-11 US claimed
US-20250367096-A1 STABILIZATION OF THIOPYRIDINONE COMPOUND AND COMPOSITION COMPRISING SAME OREAL (FR) 2025-12-04 US claimed
US-20250205131-A1 COSMETIC COMPOSITION COMPRISING THIOPYRIDINONE COMPOUNDS, REDUCING AGENT AND ARGININE L'OREAL (FR) 2025-06-26 US claimed
US-12226506-B2 Cosmetic composition comprising natural emulsifiers and thiopyridinone compounds L'OREAL (FR) 2025-02-18 US claimed
US-20230404879-A1 ENHANCING PHOTOSTABILITY OF THIOPYRIDINONE COMPOUND WITHOUT THE USE OF UV FILTERS L'OREAL (FR) 2023-12-21 US claimed
US-20230404884-A1 COSMETIC COMPOSITION COMPRISING HYDROPHILIC ANTIOXIDANTS AND THIOPYRIDINONE COMPOUNDS L'OREAL (FR) 2023-12-21 US claimed
US-20230404883-A1 COSMETIC COMPOSITION COMPRISING NATURAL EMULSIFIERS AND THIOPYRIDINONE COMPOUNDS L'OREAL (FR) 2023-12-21 US claimed
US-20230404882-A1 COMPOSITION COMPRISING COMPOUND OF THIOPYRIDINONE TYPE AND POLYGLYCERYL-BASED EMULSIFIERS L'OREAL (FR) 2023-12-21 US claimed
EP-2651897-B1 PROCESS FOR DEPIGMENTING KERATIN MATERIALS USING THIOPYRIDINONE COMPOUNDS OREAL (FR) 2020-04-01 EP claimed
EP-2651897-A1 PROCESS FOR DEPIGMENTING KERATIN MATERIALS USING THIOPYRIDINONE COMPOUNDS L'Oréal (FR) 2013-10-23 EP claimed
WO-2012080075-A1 PROCESS FOR DEPIGMENTING KERATIN MATERIALS USING THIOPYRIDINONE COMPOUNDS L'OREAL (FR) 2012-06-21 WO claimed
US-12521333-B2 Composition comprising compound of thiopyridinone type and polyglyceryl-based emulsifiers L'OREAL (FR) 2026-01-13 US disclosed
US-20250381116-A1 SOLUBILIZATION OF THIOPYRIDINONE COMPOUND AND COMPOSITION COMPRISING SAME OREAL (FR) 2025-12-18 US disclosed
US-20250381115-A1 STABILIZATION OF THIOPYRIDINONE COMPOUND AND COMPOSITION COMPRISING SAME OREAL (FR) 2025-12-18 US disclosed
US-9138392-B2 Process for depigmenting keratin materials using thiopyridinone compounds L'OREAL (FR) 2015-09-22 US disclosed
US-9138392-B2 Process for depigmenting keratin materials using thiopyridinone compounds L'OREAL (FR) 2015-09-22 US disclosed
WO-2012080075-A1 PROCESS FOR DEPIGMENTING KERATIN MATERIALS USING THIOPYRIDINONE COMPOUNDS L'OREAL (FR) 2012-06-21 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230404882-A1 COMPOSITION COMPRISING COMPOUND OF THIOPYRIDINONE TYPE AND POLYGLYCERYL-BASED EMULSIFIERS PPARG, PHOSPHO1, SQLE GAA 1405/4885HTT 1061/4885ALDH1A1 2191/4885
US-20230404884-A1 COSMETIC COMPOSITION COMPRISING HYDROPHILIC ANTIOXIDANTS AND THIOPYRIDINONE COMPOUNDS TPO, LPO, OGG1 GAA 2008/4885HTT 459/4885ALDH1A1 299/4885
US-20250375367-A1 STABILIZATION OF THIOPYRIDINONE COMPOUND AND COMPOSITION COMPRISING SAME TPMT, CRY1, TDP1 GAA 3382/4885HTT 42/4885ALDH1A1 459/4885
US-20230404883-A1 COSMETIC COMPOSITION COMPRISING NATURAL EMULSIFIERS AND THIOPYRIDINONE COMPOUNDS PPARG, PHOSPHO1, POLQ GAA 2225/4885HTT 1025/4885ALDH1A1 1575/4885
US-20250367096-A1 STABILIZATION OF THIOPYRIDINONE COMPOUND AND COMPOSITION COMPRISING SAME TPMT, DHPS, MTAP GAA 3858/4885HTT 261/4885ALDH1A1 2320/4885
US-20250381115-A1 STABILIZATION OF THIOPYRIDINONE COMPOUND AND COMPOSITION COMPRISING SAME TPMT, TPR, TYMP GAA 3088/4885HTT 280/4885ALDH1A1 2523/4885
US-12226506-B2 Cosmetic composition comprising natural emulsifiers and thiopyridinone compounds PPARG, PHOSPHO1, POLQ GAA 2225/4885HTT 1025/4885ALDH1A1 1575/4885
US-20250205131-A1 COSMETIC COMPOSITION COMPRISING THIOPYRIDINONE COMPOUNDS, REDUCING AGENT AND ARGININE PRMT1, ARG1, PRMT5 GAA 4238/4885HTT 2106/4885ALDH1A1 713/4885
US-20250381116-A1 SOLUBILIZATION OF THIOPYRIDINONE COMPOUND AND COMPOSITION COMPRISING SAME TBCB, CCNB3, CYP24A1 GAA 4523/4885HTT 3044/4885ALDH1A1 2124/4885
US-20230404879-A1 ENHANCING PHOTOSTABILITY OF THIOPYRIDINONE COMPOUND WITHOUT THE USE OF UV FILTERS TYR, TST, TSN GAA 2602/4885HTT 2662/4885ALDH1A1 2063/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.