SCHEMBL9937087

SCHEMBL9937087

O=C(NCc1ccccc1)c1ccc[nH]c1=S

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 4/20 0.59
METAP2 P50579 1/20 0.59
GAA P10253 5/20 0.56
HPGD P15428 2/20 0.56
LMNA P02545 1/20 0.56
L3MBTL1 Q9Y468 1/20 0.56
KDM4E B2RXH2 3/20 0.56
MAPT P10636 1/20 0.56
APEX1 P27695 1/20 0.55
CHRNB2 P17787 1/20 0.55
CHRNB4 P30926 1/20 0.55
CHRNA3 P32297 1/20 0.55
CHRNA4 P43681 1/20 0.55
TP53 P04637 1/20 0.52
GLA P06280 1/20 0.52
NSD2 O96028 2/20 0.51
SGMS2 Q8NHU3 1/20 0.51
HTT P42858 3/20 0.50
ALDH1A1 P00352 2/20 0.50
MEN1 O00255 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18985201 0.81 GAA (0.59) GAAKDM4EMAPTHTTALDH1A1
SCHEMBL31680569 0.80 KMT2A (0.89) KMT2AMETAP2GAAHPGDLMNA
SCHEMBL11901003 0.80 KMT2A (0.89) KMT2AMETAP2GAAHPGDLMNA
SCHEMBL19017268 0.80 KMT2A (0.54) KMT2AGAAHPGDLMNAL3MBTL1
SCHEMBL9936614 0.80 GAA (0.56) KMT2AGAAL3MBTL1KDM4EMAPT
SCHEMBL9935989 0.78 GAA (0.59) KMT2AGAAKDM4EMAPTHTT
SCHEMBL2576103 0.78 KDM4E (0.74) KMT2AGAALMNAKDM4E
SCHEMBL9936595 0.77 GAA (0.61) KMT2AGAAKDM4EMAPTHTT
SCHEMBL9935825 0.77 GAA (0.57) GAAHPGDL3MBTL1KDM4EMAPT
SCHEMBL4458986 0.77 GAA (0.54) KMT2AGAALMNAKDM4EMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12521333-B2 Composition comprising compound of thiopyridinone type and polyglyceryl-based emulsifiers L'OREAL (FR) 2026-01-13 US claimed
US-20250381115-A1 STABILIZATION OF THIOPYRIDINONE COMPOUND AND COMPOSITION COMPRISING SAME OREAL (FR) 2025-12-18 US claimed
US-20250381116-A1 SOLUBILIZATION OF THIOPYRIDINONE COMPOUND AND COMPOSITION COMPRISING SAME OREAL (FR) 2025-12-18 US claimed
US-20250375367-A1 STABILIZATION OF THIOPYRIDINONE COMPOUND AND COMPOSITION COMPRISING SAME OREAL (FR) 2025-12-11 US claimed
US-20250367096-A1 STABILIZATION OF THIOPYRIDINONE COMPOUND AND COMPOSITION COMPRISING SAME OREAL (FR) 2025-12-04 US claimed
US-20250205131-A1 COSMETIC COMPOSITION COMPRISING THIOPYRIDINONE COMPOUNDS, REDUCING AGENT AND ARGININE L'OREAL (FR) 2025-06-26 US claimed
US-12226506-B2 Cosmetic composition comprising natural emulsifiers and thiopyridinone compounds L'OREAL (FR) 2025-02-18 US claimed
US-20230404883-A1 COSMETIC COMPOSITION COMPRISING NATURAL EMULSIFIERS AND THIOPYRIDINONE COMPOUNDS L'OREAL (FR) 2023-12-21 US claimed
US-20230404882-A1 COMPOSITION COMPRISING COMPOUND OF THIOPYRIDINONE TYPE AND POLYGLYCERYL-BASED EMULSIFIERS L'OREAL (FR) 2023-12-21 US claimed
US-20230404884-A1 COSMETIC COMPOSITION COMPRISING HYDROPHILIC ANTIOXIDANTS AND THIOPYRIDINONE COMPOUNDS L'OREAL (FR) 2023-12-21 US claimed
US-20230404879-A1 ENHANCING PHOTOSTABILITY OF THIOPYRIDINONE COMPOUND WITHOUT THE USE OF UV FILTERS L'OREAL (FR) 2023-12-21 US claimed
EP-2651897-B1 PROCESS FOR DEPIGMENTING KERATIN MATERIALS USING THIOPYRIDINONE COMPOUNDS OREAL (FR) 2020-04-01 EP claimed
EP-2651897-A1 PROCESS FOR DEPIGMENTING KERATIN MATERIALS USING THIOPYRIDINONE COMPOUNDS L'Oréal (FR) 2013-10-23 EP claimed
WO-2012080075-A1 PROCESS FOR DEPIGMENTING KERATIN MATERIALS USING THIOPYRIDINONE COMPOUNDS L'OREAL (FR) 2012-06-21 WO claimed
US-12521333-B2 Composition comprising compound of thiopyridinone type and polyglyceryl-based emulsifiers L'OREAL (FR) 2026-01-13 US disclosed
US-20250381116-A1 SOLUBILIZATION OF THIOPYRIDINONE COMPOUND AND COMPOSITION COMPRISING SAME OREAL (FR) 2025-12-18 US disclosed
US-20250381115-A1 STABILIZATION OF THIOPYRIDINONE COMPOUND AND COMPOSITION COMPRISING SAME OREAL (FR) 2025-12-18 US disclosed
US-9138392-B2 Process for depigmenting keratin materials using thiopyridinone compounds L'OREAL (FR) 2015-09-22 US disclosed
US-9138392-B2 Process for depigmenting keratin materials using thiopyridinone compounds L'OREAL (FR) 2015-09-22 US disclosed
WO-2012080075-A1 PROCESS FOR DEPIGMENTING KERATIN MATERIALS USING THIOPYRIDINONE COMPOUNDS L'OREAL (FR) 2012-06-21 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230404882-A1 COMPOSITION COMPRISING COMPOUND OF THIOPYRIDINONE TYPE AND POLYGLYCERYL-BASED EMULSIFIERS PPARG, PHOSPHO1, SQLE KMT2A 1525/4885METAP2 2534/4885GAA 1405/4885
US-20230404884-A1 COSMETIC COMPOSITION COMPRISING HYDROPHILIC ANTIOXIDANTS AND THIOPYRIDINONE COMPOUNDS TPO, LPO, OGG1 KMT2A 1110/4885METAP2 1527/4885GAA 2008/4885
US-20250375367-A1 STABILIZATION OF THIOPYRIDINONE COMPOUND AND COMPOSITION COMPRISING SAME TPMT, CRY1, TDP1 KMT2A 399/4885METAP2 2321/4885GAA 3382/4885
US-20230404883-A1 COSMETIC COMPOSITION COMPRISING NATURAL EMULSIFIERS AND THIOPYRIDINONE COMPOUNDS PPARG, PHOSPHO1, POLQ KMT2A 891/4885METAP2 2364/4885GAA 2225/4885
US-20250367096-A1 STABILIZATION OF THIOPYRIDINONE COMPOUND AND COMPOSITION COMPRISING SAME TPMT, DHPS, MTAP KMT2A 807/4885METAP2 961/4885GAA 3858/4885
US-20250381115-A1 STABILIZATION OF THIOPYRIDINONE COMPOUND AND COMPOSITION COMPRISING SAME TPMT, TPR, TYMP KMT2A 683/4885METAP2 518/4885GAA 3088/4885
US-12226506-B2 Cosmetic composition comprising natural emulsifiers and thiopyridinone compounds PPARG, PHOSPHO1, POLQ KMT2A 891/4885METAP2 2364/4885GAA 2225/4885
US-20250205131-A1 COSMETIC COMPOSITION COMPRISING THIOPYRIDINONE COMPOUNDS, REDUCING AGENT AND ARGININE PRMT1, ARG1, PRMT5 KMT2A 643/4885METAP2 1514/4885GAA 4238/4885
US-20250381116-A1 SOLUBILIZATION OF THIOPYRIDINONE COMPOUND AND COMPOSITION COMPRISING SAME TBCB, CCNB3, CYP24A1 KMT2A 3398/4885METAP2 1569/4885GAA 4523/4885
US-20230404879-A1 ENHANCING PHOTOSTABILITY OF THIOPYRIDINONE COMPOUND WITHOUT THE USE OF UV FILTERS TYR, TST, TSN KMT2A 468/4885METAP2 1865/4885GAA 2602/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.