SCHEMBL9972407

SCHEMBL9972407

O=C(O)CCCCC(=O)OCCOCCOC(=O)CCCCC(=O)O

nearest known ligand 0.54

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
DGKA P23743 1/20 0.54
LMNA P02545 2/20 0.50
TSHR P16473 3/20 0.48
NFKB1 P19838 2/20 0.48
PMP22 Q01453 1/20 0.48
NPC1 O15118 1/20 0.45
ALDH1A1 P00352 1/20 0.45
PAM P19021 2/20 0.44
SLC22A6 Q4U2R8 1/20 0.43
GPR84 Q9NQS5 1/20 0.41
FFAR1 O14842 1/20 0.41
FFAR4 Q5NUL3 1/20 0.41
AKR1B1 P15121 1/20 0.41
CYP2D6 P10635 1/20 0.41
FOLH1 Q04609 1/20 0.41
TDP1 Q9NUW8 1/20 0.41
DNM1 Q05193 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10783946 1.00 DGKA (0.54) DGKALMNATSHRNFKB1PMP22
SCHEMBL17637589 0.98 DGKA (0.57) DGKALMNATSHRNFKB1PMP22
Ethylene SCHEMBL9250257 0.96 DGKA (0.50) DGKALMNATSHRNFKB1PMP22
Ethylene SCHEMBL9774406 0.96 DGKA (0.50) DGKALMNATSHRNFKB1PMP22
SCHEMBL421182 0.96 DGKA (0.50) DGKALMNATSHRNFKB1PMP22
SCHEMBL1389328 0.95 TSHR (0.52) DGKALMNATSHRNFKB1PMP22
SCHEMBL15445484 0.93 DGKA (0.52) DGKALMNATSHRNFKB1PMP22
SCHEMBL536437 0.93 DGKA (0.60) DGKALMNATSHRNFKB1PMP22
SCHEMBL207582 0.92 EPHX2 (0.48) DGKALMNATSHRNFKB1PMP22
SCHEMBL11643278 0.92 EPHX2 (0.48) DGKALMNATSHRNFKB1PMP22

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20170112939-A1 PREVENTION AND TREATMENT OF OCULAR CONDITIONS Ascendis Pharma Ophthamology Division A/S (DK) 2017-04-27 US disclosed
US-20160296600-A1 Relaxin Prodrugs ASCENDIS PHARMA RELAXIN DIVISION A/S (DK) 2016-10-13 US disclosed
US-20160296600-A1 Relaxin Prodrugs ASCENDIS PHARMA RELAXIN DIVISION A/S (DK) 2016-10-13 US disclosed
US-9457066-B2 Prodrugs comprising an insulin linker conjugate SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) 2016-10-04 US disclosed
US-9457066-B2 Prodrugs comprising an insulin linker conjugate SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) 2016-10-04 US disclosed
US-20160082123-A1 Hydrogel-Linked Prodrugs Releasing Tagged Drugs ASCENDIS PHARMA A/S (DK) 2016-03-24 US disclosed
US-20160082123-A1 Hydrogel-Linked Prodrugs Releasing Tagged Drugs ASCENDIS PHARMA A/S (DK) 2016-03-24 US disclosed
US-9278139-B2 Sterilization of biodegradable hydrogels ASCENDIS PHARMA A/S (DK) 2016-03-08 US disclosed
US-9173953-B2 Prodrugs containing an aromatic amine connected by an amido bond to a linker ASCENDIS PHARMA AS (DK) 2015-11-03 US disclosed
US-9173953-B2 Prodrugs containing an aromatic amine connected by an amido bond to a linker ASCENDIS PHARMA AS (DK) 2015-11-03 US disclosed
US-20150010634-A1 PREVENTION AND TREATMENT OF OCULAR CONDITIONS Ascendis Pharma Ophthamology Division A/S (DK) 2015-01-08 US disclosed
US-20120253071-A1 Sterilization of biodegradable hydrogels ASCENDIS PHARMA A/S (DK) 2012-10-04 US disclosed
US-20120191039-A1 CARRIER LINKED PRAMIPEXOLE PRODRUGS ASCENDIS PHARMA A/S (DK) 2012-07-26 US disclosed
US-20120191039-A1 CARRIER LINKED PRAMIPEXOLE PRODRUGS ASCENDIS PHARMA A/S (DK) 2012-07-26 US disclosed
US-20120184489-A1 PRODRUGS COMPRISING AN INSULIN LINKER CONJUGATE SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) 2012-07-19 US disclosed
US-20120183616-A1 LONG ACTING INSULIN COMPOSITION SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) 2012-07-19 US disclosed
US-20120184489-A1 PRODRUGS COMPRISING AN INSULIN LINKER CONJUGATE SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) 2012-07-19 US disclosed
US-20120156259-A1 Biodegradable Polyethylene Glycol Based Water-Insoluble Hydrogels ASCENDIS PHARMA A/S (DK) 2012-06-21 US disclosed
US-20120156260-A1 Prodrugs Containing an Aromatic Amine Connected By an Amido Bond to a Linker ASCENDIS PHARMA A/S (DK) 2012-06-21 US disclosed
US-20120156259-A1 Biodegradable Polyethylene Glycol Based Water-Insoluble Hydrogels ASCENDIS PHARMA A/S (DK) 2012-06-21 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120156260-A1 Prodrugs Containing an Aromatic Amine Connected By an Amido Bond to a Linker DAO, DNPEP, DDC DGKA 2693/4885LMNA 759/4885TSHR 2404/4885
US-20170112939-A1 PREVENTION AND TREATMENT OF OCULAR CONDITIONS PDE6C, ALDH1A2, UACA DGKA 2201/4885LMNA 1992/4885TSHR 2660/4885
US-20120156259-A1 Biodegradable Polyethylene Glycol Based Water-Insoluble Hydrogels PLG, PHYKPL, PLOD3 DGKA 1014/4885LMNA 3156/4885TSHR 3360/4885
US-20160296600-A1 Relaxin Prodrugs RXFP1, RXFP2, RXFP3 DGKA 4264/4885LMNA 638/4885TSHR 215/4885
US-20120184489-A1 PRODRUGS COMPRISING AN INSULIN LINKER CONJUGATE IAPP, IGF1R, INSR DGKA 1749/4885LMNA 332/4885TSHR 721/4885
US-20120183616-A1 LONG ACTING INSULIN COMPOSITION IAPP, INSR, GPR119 DGKA 1347/4885LMNA 641/4885TSHR 724/4885
US-20120253071-A1 Sterilization of biodegradable hydrogels USP3, USP30, USP4 DGKA 1801/4885LMNA 3589/4885TSHR 1671/4885
US-20120191039-A1 CARRIER LINKED PRAMIPEXOLE PRODRUGS PRAP1, LPXN, DNPEP DGKA 3211/4885LMNA 1878/4885TSHR 3721/4885
US-20160082123-A1 Hydrogel-Linked Prodrugs Releasing Tagged Drugs PTMS, PGLS, PAM DGKA 2826/4885LMNA 3651/4885TSHR 1252/4885
US-20150010634-A1 PREVENTION AND TREATMENT OF OCULAR CONDITIONS PDE6C, ALDH1A2, UACA DGKA 2201/4885LMNA 1992/4885TSHR 2660/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.