Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 known ✓ | P00915 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.48 |
| ▸ | FFAR3 | O14843 | 3/20 | 0.48 |
| ▸ | CES2 | O00748 | 6/20 | 0.48 |
| ▸ | CES1 | P23141 | 6/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MMP1 | P03956 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | CTSD | P07339 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1023545 | 0.85 | CES1 (0.52) | HDAC3HDAC1HDAC2HDAC8FFAR3 | |
| SCHEMBL1021844 | 0.78 | LMNA (0.45) | HDAC3HDAC1HDAC2HDAC8FFAR3 | |
| Lithium Ion SCHEMBL16987204 | 0.77 | CES2 (0.56) | CES2CES1TSHRALDH1A1 | |
| Lithium Ion SCHEMBL16987212 | 0.77 | CES2 (0.56) | CES2CES1TSHRALDH1A1 | |
| Lithium Ion SCHEMBL16987213 | 0.77 | CES2 (0.56) | CES2CES1TSHRALDH1A1 | |
| SCHEMBL1023544 | 0.77 | FFAR3 (0.41) | HDAC3HDAC1HDAC2HDAC8FFAR3 | |
| SCHEMBL9313976 | 0.76 | LMNA (0.43) | CES2CES1LMNACA1TSHR | |
| SCHEMBL9334997 | 0.74 | LMNA (0.41) | HDAC3HDAC1HDAC2HDAC8CES2 | |
| SCHEMBL9332102 | 0.74 | LMNA (0.41) | HDAC3HDAC1HDAC2HDAC8CES2 | |
| SCHEMBL9333464 | 0.74 | LMNA (0.41) | HDAC3HDAC1HDAC2HDAC8CES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 47 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11607370-B2 | Dental composition | KURARAY NORITAKE DENTAL INC. (JP) | 2023-03-21 | — | — | US | disclosed |
| US-11547639-B2 | Dental composition containing platinum nanoparticles | KURARAY NORITAKE DENTAL INC. (JP) | 2023-01-10 | — | — | US | disclosed |
| US-20210186823-A1 | DENTAL COMPOSITION | KURARAY NORITAKE DENTAL INC. (JP) | 2021-06-24 | — | — | US | disclosed |
| US-20200390661-A1 | DENTAL COMPOSITION CONTAINING PLATINUM NANOPARTICLES | KURARAY NORITAKE DENTAL INC. (JP) | 2020-12-17 | — | — | US | disclosed |
| EP-3725288-A1 | DENTAL COMPOSITION CONTAINING PLATINUM NANOPARTICLES | Kuraray Noritake Dental Inc. (JP) | 2020-10-21 | — | — | EP | disclosed |
| EP-3701930-A1 | DENTAL COMPOSITION | Kuraray Noritake Dental Inc. (JP) | 2020-09-02 | — | — | EP | disclosed |
| EP-2226060-B1 | CEMENT FOR DENTAL APPLICATIONS | KURARAY NORITAKE DENTAL INC (JP) | 2020-03-04 | — | — | EP | disclosed |
| EP-2279723-B1 | DENTAL COMPOSITION AND COMPOSITE RESIN | KURARAY NORITAKE DENTAL INC (JP) | 2017-03-01 | — | — | EP | disclosed |
| EP-2275076-B1 | DENTAL COMPOSITION AND COMPOSITE RESIN | KURARAY NORITAKE DENTAL INC (JP) | 2017-03-01 | — | — | EP | disclosed |
| EP-2133368-B1 | POLYMERIZABLE MONOMER, POLYMERIZABLE COMPOSITION AND DENTAL MATERIAL | KURARAY NORITAKE DENTAL INC (JP) | 2017-01-25 | — | — | EP | disclosed |
| US-20100056665-A1 | POLYMERIZABLE MONOMER, POLYMERIZABLE COMPOSITION AND DENTAL MATERIAL | KURARAY MEDICAL INC. (JP) | 2010-03-04 | — | — | US | disclosed |
| US-20100048761-A1 | POLYMERIZABLE MONOMER-CONTAINING COMPOSITION | KURARAY MEDICAL INC. (JP) | 2010-02-25 | — | — | US | disclosed |
| US-20100048762-A1 | COMPOSITION AND DENTAL MATERIAL | KURARAY MEDICAL INC. (JP) | 2010-02-25 | — | — | US | disclosed |
| US-20100036075-A1 | POLYMERIZABLE MONOMER-CONTAINING COMPOSITION | KURARAY MEDICAL INC. (JP) | 2010-02-11 | — | — | US | disclosed |
| EP-2133368-A1 | POLYMERIZABLE MONOMER, POLYMERIZABLE COMPOSITION AND DENTAL MATERIAL | Kuraray Medical Inc. (JP) | 2009-12-16 | — | — | EP | disclosed |
| EP-2112178-A1 | POLYMERIZABLE MONOMER-CONTAINING COMPOSITION | Kuraray Medical Inc. (JP) | 2009-10-28 | — | — | EP | disclosed |
| EP-2112177-A1 | POLYMERIZABLE MONOMER-CONTAINING COMPOSITION | Kuraray Medical Inc. (JP) | 2009-10-28 | — | — | EP | disclosed |
| EP-2108663-A1 | POLYMERIZABLE MONOMER, POLYMERIZABLE COMPOSITION AND DENTAL MATERIAL | Kuraray Medical Inc. (JP) | 2009-10-14 | — | — | EP | disclosed |
| EP-2108664-A1 | COMPOSITION AND DENTAL MATERIAL | Kuraray Medical Inc. (JP) | 2009-10-14 | — | — | EP | disclosed |
| EP-2070935-A1 | NOVEL COMPOUND, COMPOSITION COMPRISING THE SAME, AND PROCESS FOR PRODUCTION OF POLYMERIZABLE AMIDE | Kuraray Medical Inc. (JP) | 2009-06-17 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11607370-B2 | Dental composition | ITGAL, ITGA1, ITGB3 | CA1 348/4885HDAC3 361/4885HDAC1 364/4885 |
| US-20100048761-A1 | POLYMERIZABLE MONOMER-CONTAINING COMPOSITION | WDR82, PWWP2B, WDR5 | CA1 150/4885HDAC3 4226/4885HDAC1 3136/4885 |
| US-20100048762-A1 | COMPOSITION AND DENTAL MATERIAL | PHOSPHO1, PDS5B, ITGB5 | CA1 528/4885HDAC3 3494/4885HDAC1 1832/4885 |
| US-20210186823-A1 | DENTAL COMPOSITION | ITGAL, ITGA1, ITGB3 | CA1 348/4885HDAC3 361/4885HDAC1 364/4885 |
| US-20100056665-A1 | POLYMERIZABLE MONOMER, POLYMERIZABLE COMPOSITION AND DENTAL MATERIAL | ITGA1, COL1A1, MACF1 | CA1 339/4885HDAC3 3555/4885HDAC1 1045/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.