Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Acetophenone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB known ✓ | P27338 | 1/20 | 0.50 |
| ▸ | PARP1 known ✓ | P09874 | 1/20 | 0.50 |
| ▸ | CA2 known ✓ | P00918 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.68 |
| ▸ | HPGD | P15428 | 4/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | CES2 | O00748 | 3/20 | 0.59 |
| ▸ | CES1 | P23141 | 3/20 | 0.59 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 3/20 | 0.55 |
| ▸ | DAO | P14920 | 1/20 | 0.55 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetophenone SCHEMBL27600039 | 1.00 | MAPT (0.68) | MAPTSMN1; SMN2HPGDALDH1A1LMNA | |
| Acetophenone SCHEMBL11354178 | 1.00 | MAPT (0.68) | MAPTSMN1; SMN2HPGDALDH1A1LMNA | |
| Acetophenone SCHEMBL11683047 | 0.97 | MAPT (0.65) | MAPTSMN1; SMN2HPGDALDH1A1LMNA | |
| Acetophenone SCHEMBL10706513 | 0.97 | MAPT (0.65) | MAPTSMN1; SMN2HPGDALDH1A1LMNA | |
| Acetophenone SCHEMBL27865122 | 0.97 | MAPT (0.65) | MAPTSMN1; SMN2HPGDALDH1A1LMNA | |
| Acetophenone SCHEMBL11683044 | 0.97 | SMN1; SMN2 (0.65) | MAPTSMN1; SMN2HPGDALDH1A1LMNA | |
| Acetophenone SCHEMBL10707314 | 0.97 | MAPT (0.65) | MAPTSMN1; SMN2HPGDALDH1A1LMNA | |
| Acetophenone SCHEMBL1450855 | 0.97 | — | — | |
| Acetophenone SCHEMBL16745259 | 0.97 | — | — | |
| Acetophenone SCHEMBL737 | 0.97 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 206 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106852143-B | Tricyclic triazolic compounds | 埃斯蒂维制药股份公司 | 2019-07-16 | — | — | CN | claimed |
| CN-106478612-B | 2- [4- (quinoxaline -2- base oxygroup) phenoxy group] amide derivatives and the preparation method and application thereof | 湖南大学 | 2019-02-15 | — | — | CN | claimed |
| CN-106324794-B | A kind of the chip automatic focusing device and its focus adjustment method of gene profile sequencing equipment | 徐州工程学院 | 2018-10-23 | — | — | CN | claimed |
| CN-106217625-B | A kind of multi-functional curing means of large-sized reinforced concrete profiled member and its method of work | 徐州工程学院 | 2018-04-13 | — | — | CN | claimed |
| CN-107531615-A | Indenyl compound, pharmaceutical composition and medical application thereof | ADT制药有限责任公司 | 2018-01-02 | — | — | CN | claimed |
| CN-105263933-B | A kind of simultaneously [1,2 a] benzazolyl compounds and preparation method thereof and the application in medicine of pyrazine | 埃斯蒂维实验室股份有限公司 | 2017-12-22 | — | — | CN | claimed |
| CN-106999473-A | Purposes of the sigma-receptor part in osteoarthritis | 埃斯蒂文博士实验室股份有限公司 | 2017-08-01 | — | — | CN | claimed |
| CN-104507939-B | tetrahydropyrazolopyrimidine compounds | 卫材R&D管理有限公司 | 2017-07-25 | — | — | CN | claimed |
| CN-106852143-A | Tricyclic triazolic compounds | 埃斯蒂维实验室股份有限公司 | 2017-06-13 | — | — | CN | claimed |
| CN-105263933-A | Pyrazino[1,2-a]indole compounds, their preparation and use in medicaments | ESTEVE LABOR DR | 2016-01-20 | — | — | CN | claimed |
| CN-104507939-A | Tetrahydropyrazolopyrimidine compounds | EISAI R&D MAN CO LTD | 2015-04-08 | — | — | CN | claimed |
| CN-103228633-A | Heterocyclic compounds as DGAT1 inhibitors | PIRAMAL LIFE SCIENCES LTD | 2013-07-31 | — | — | CN | claimed |
| CN-102007102-A | Modulators of the histamine h3 receptor useful for the treatment of disorders related thereto | ARENA PHARM INC | 2011-04-06 | — | — | CN | claimed |
| CN-101553481-A | Substituted sulfonamide derivatives | GRUENENTHAL GMBH (DE) | 2009-10-07 | — | — | CN | claimed |
| CN-1554649-A | Metabotropic glutamate receptor antagonists for treating central nervous system diseases | NPSҩ������˾ | 2004-12-15 | — | — | CN | claimed |
| CN-1285820-A | Metabotropic glutamate receptor antagonists for the treatment of central nervous system disorders | NPS PHARMA INC (US) | 2001-02-28 | — | — | CN | claimed |
| CN-1003013-B | Synthesis of nitro acetophenone hydrochloride as intermediate of antidepressant Nomifenin | 国家医药管理局天津药物研究院 | 1989-01-04 | — | — | CN | claimed |
| CN-113831218-B | Method for preparing 4-fluorophenyl ethylene oxide | 利尔化学股份有限公司 | 2023-11-28 | — | — | CN | disclosed |
| CN-86108706-A | Synthesizing of alchol of antimelancholic ' Nomifensin ' intermediate nitro-acetophenone hydrochloride | — | 1987-12-23 | — | — | CN | disclosed |
| EP-0043807-B1 | 1-(DIHYDROXYPHENYL)-2-AMINO-ETHANOL DERIVATIVES; PREPARATION, COMPOSITIONS AND INTERMEDIATES | Aktiebolaget Draco (SE) | 1984-05-30 | — | — | EP | disclosed |