Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Polihexanide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RRM1 known ✓ | P23921 | 1/20 | 0.38 |
| ▸ | SPHK1 | Q9NYA1 | 5/20 | 0.49 |
| ▸ | EPHX1 | P07099 | 8/20 | 0.45 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.42 |
| ▸ | CASP2 | P42575 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.39 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.39 |
| ▸ | NAAA | Q02083 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4476798 | 1.00 | SPHK1 (0.49) | SPHK1EPHX1SPHK2CASP2MEN1 | |
| Hydrochloric Acid SCHEMBL9667167 | 1.00 | SPHK1 (0.49) | SPHK1EPHX1SPHK2CASP2MEN1 | |
| Polihexanide SCHEMBL8515092 | 1.00 | SPHK1 (0.49) | SPHK1EPHX1SPHK2CASP2MEN1 | |
| Hydrochloric Acid SCHEMBL1900717 | 1.00 | SPHK1 (0.49) | SPHK1EPHX1SPHK2CASP2MEN1 | |
| Hydrochloric Acid SCHEMBL8898546 | 1.00 | SPHK1 (0.49) | SPHK1EPHX1SPHK2CASP2MEN1 | |
| Polihexanide SCHEMBL45011 | 0.98 | EPHX1 (0.47) | SPHK1EPHX1SPHK2CASP2MEN1 | |
| SCHEMBL3921623 | 0.98 | EPHX1 (0.47) | SPHK1EPHX1SPHK2CASP2MEN1 | |
| SCHEMBL5133441 | 0.98 | EPHX1 (0.47) | SPHK1EPHX1SPHK2CASP2MEN1 | |
| SCHEMBL245909 | 0.98 | EPHX1 (0.47) | SPHK1EPHX1SPHK2CASP2MEN1 | |
| SCHEMBL4111428 | 0.98 | EPHX1 (0.47) | SPHK1EPHX1SPHK2CASP2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 2548 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12297597-B2 | Cellulose composition | KEMIRA OYJ (FI) | 2025-05-13 | — | — | US | claimed |
| CN-117987952-A | Preparation method of stock solution coloring polylactic acid fiber | 中国石油化工股份有限公司 | 2024-05-07 | — | — | CN | claimed |
| EP-2916820-B1 | DELIVERY OF BIOLOGICALLY-ACTIVE AGENTS USING VOLATILE, HYDROPHOBIC SOLVENTS | ROCHAL TECH LLC (US) | 2023-10-11 | — | — | EP | claimed |
| US-20230257682-A1 | FABRIC CARE COMPOSITIONS WITH DOSE-DEPENDENT ANTIMICROBIAL ACTIVITIES THAT REDUCE THE RISK OF INFECTION AND PROMOTE HEALTH AND HYGIENE WHEN USED DISCRETELY OR SYNERGISTICALLY IN A MACHINE WASHING AND DRYING LAUNDRY PROGRAM | TJBS IP Management, LLC (US) | 2023-08-17 | — | — | US | claimed |
| CN-116444866-A | Cellulose composition | 凯米拉公司 | 2023-07-18 | — | — | CN | claimed |
| CN-116396809-A | Preparation method of kitchen wet tissue | 橙的(福建)卫生用品有限责任公司 | 2023-07-07 | — | — | CN | claimed |
| CN-116349679-A | Composite disinfection and sterilization method | 孙国明 | 2023-06-30 | — | — | CN | claimed |
| CN-112673053-B | Cellulose composition | 凯米拉公司 | 2023-05-02 | — | — | CN | claimed |
| CN-116034994-A | Disinfection mother liquor and raw material composition, preparation method and application thereof | 上海明涌新材料有限公司 | 2023-05-02 | — | — | CN | claimed |
| CN-111393637-B | Modified polyguanidine salt antibacterial mildew inhibitor, preparation method thereof and application thereof in silicone structural sealant | 安阳崇高纳米材料科技有限公司 | 2023-03-31 | — | — | CN | claimed |
| US-5786282-A | Opened wet processed intermediate natural fiber product suitable for formation into end use fiber products with long-lasting antimicrobial properties and method | BARNHARDT MANUFACTURING COMPANY (US) | 1998-07-28 | — | — | US | claimed |
| US-5670160-A | ORGANIC ACID, ALCOHOL, POLY(HEXAMETHYLENEBIGUANIDE) SALT | SCHULKE & MAYR GMBH (DE) | 1997-09-23 | — | — | US | claimed |
| WO-1997000076-A1 | COMPOSITIONS CONTAINING POLY(HEXAMETHYLENE BIGUANIDE) SALTS AND USES THEREOF | MOORFIELDS EYE HOSPITAL (GB) | 1997-01-03 | — | — | WO | claimed |
| EP-0690728-A1 | PRESERVATIVE SYSTEM FOR CONTACT LENS SOLUTIONS | POLYMER TECHNOLOGY CORPORATION (US) | 1996-01-10 | — | — | EP | claimed |
| US-5453435-A | Microbiocides for eyes | POLYMER TECHNOLOGY CORPORATION (US) | 1995-09-26 | — | — | US | claimed |
| US-5449658-A | Biocidal compositions comprising polyhexamethylene biguanide and EDTA, and methods for treating commercial and recreational water | ZENECA, INC. (US) | 1995-09-12 | — | — | US | claimed |
| WO-1995015683-A1 | BIOCIDAL COMPOSITIONS AND METHODS FOR TREATING COMMERCIAL AND RECREATIONAL WATER | ZENECA, INC. (US) | 1995-06-15 | — | — | WO | claimed |
| WO-1994015649-A1 | PRESERVATIVE SYSTEM FOR CONTACT LENS SOLUTIONS | POLYMER TECHNOLOGY CORPORATION (US) | 1994-07-21 | — | — | WO | claimed |
| EP-0041448-B1 | DISINFECTING COMPOSITION CONTAINING A QUATERNARY AMMONIUM AND AN OLIGOMER OF HEXAMETHYLENE-DIGUANIDE HYDROCHLORIDE | Salkin, Nicolas (FR) | 1984-12-12 | — | — | EP | claimed |
| US-4253971-A | APPLYING BIGUANIDE POLYMER, ALGICIDE | ZENECA, INC. | 1981-03-03 | — | — | US | claimed |