Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Pyridazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pyridazine SCHEMBL6054191 | 1.00 | TSHR (0.39) | — | |
| Pyridazine SCHEMBL692917 | 1.00 | — | — | |
| Pyridazine SCHEMBL30294987 | 1.00 | — | — | |
| Pyridazine SCHEMBL5899626 | 1.00 | TSHR (0.39) | — | |
| Pyridazine SCHEMBL750100 | 1.00 | — | — | |
| Benzene SCHEMBL4552313 | 0.95 | TSHR (0.46) | — | |
| Benzene SCHEMBL6061023 | 0.95 | TSHR (0.46) | — | |
| Pyridazine SCHEMBL5104 | 0.94 | — | — | |
| Pyridazine SCHEMBL11423 | 0.94 | TSHR (0.42) | — | |
| Pyridazine SCHEMBL29471424 | 0.94 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 147 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113698421-B | Thiadiazole isoxazoline compound, preparation method and application thereof, and herbicide | 南开大学 | 2024-07-30 | — | — | CN | claimed |
| CN-113698421-A | Thiadiazole isoxazoline compound, preparation method and application thereof, and herbicide | 南开大学 | 2021-11-26 | — | — | CN | claimed |
| CN-110143947-A | A kind of preparation method of Ceritinib analog | 华东师范大学 | 2019-08-20 | — | — | CN | claimed |
| EP-4126105-B1 | APHERESIS COLUMN FOR TREATING RHEUMATOID POLYARTHRITIS | UNIV TOULOUSE 3 PAUL SABATIER (FR) | 2026-04-15 | — | — | EP | disclosed |
| CN-113698421-B | Thiadiazole isoxazoline compound, preparation method and application thereof, and herbicide | 南开大学 | 2024-07-30 | — | — | CN | disclosed |
| WO-2024131893-A1 | IRE1α SMALL MOLECULE INHIBITORS | SHANGHAI YI ZHONG XING BIOTECHNOLOGY CO., LTD. (CN) | 2024-06-27 | — | — | WO | disclosed |
| WO-2024041621-A1 | K-RAS MUTANT PROTEIN INHIBITORS | JACOBIO PHARMACEUTICALS CO., LTD. (CN) | 2024-02-29 | — | — | WO | disclosed |
| EP-4281439-A1 | SMALL MOLECULE REGULATORS OF ALVEOLAR TYPE 2 CELL PROLIFERATION FOR THE TREATMENT OF PULMONARY DISEASES | The Scripps Research Institute (US) | 2023-11-29 | — | — | EP | disclosed |
| EP-4210824-A1 | INHIBITORS OF SPINSTER HOMOLOG 2 (SPNS2) FOR USE IN THERAPY | University of Virginia Patent Foundation (US) | 2023-07-19 | — | — | EP | disclosed |
| CN-116348487-A | Anti-amyloid beta antibodies | 欧萨尔普罗席纳有限公司 | 2023-06-27 | — | — | CN | disclosed |
| EP-4126105-A1 | APHERESIS COLUMN FOR TREATING RHEUMATOID ARTHRITIS | Université Paul Sabatier Toulouse III (FR) | 2023-02-08 | — | — | EP | disclosed |
| WO-1999006404-A1 | 1,2,4-TRIAZOLO[4,3-B]PYRIDO[3,2-D]PYRIDAZINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ALMIRALL PRODESFARMA S.A. (ES) | 1999-02-11 | — | — | WO | disclosed |
| EP-0876346-A1 | ANTIMALARIAL QUINOLIN DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1998-11-11 | — | — | EP | disclosed |
| EP-0628550-B1 | Pyridazines as interleukin-1beta converting enzyme inhibitors | SANOFI SA (FR) | 1998-02-25 | — | — | EP | disclosed |
| WO-1997018193-A1 | ANTIMALARIAL QUINOLIN DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1997-05-22 | — | — | WO | disclosed |
| CN-1096821-A | The BPI-immunoglobulin fusion proteins | XOMA CORP (US) | 1994-12-28 | — | — | CN | disclosed |
| EP-0628550-A2 | Pyridazines as interleukin-1beta converting enzyme inhibitors | STERLING WINTHROP INC. (US) | 1994-12-14 | — | — | EP | disclosed |
| CN-1056102-A | Pyridazines and process for preparing them | BYK GULDEN LOMBERG CHEM FAB (DE) | 1991-11-13 | — | — | CN | disclosed |
| CN-86105558-A | The preparation method of new (4-replaces-piperazinyl) pyridazine class | — | 1987-01-28 | — | — | CN | disclosed |
| EP-0074863-B1 | PYRIDAZINE DERIVATIVE ACTIVE ON THE CENTRAL NERVE SYSTEM | SANOFI S.A. (FR) | 1986-02-26 | — | — | EP | disclosed |