Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Pyritinol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA known ✓ | P10253 | 2/20 | 0.39 |
| ▸ | CA2 known ✓ | P00918 | 2/20 | 0.36 |
| ▸ | MAOB known ✓ | P27338 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.71 |
| ▸ | HPGD | P15428 | 2/20 | 0.71 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.71 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.49 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.49 |
| ▸ | PDXK | O00764 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | AOX1 | Q06278 | 1/20 | 0.46 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pyritinol SCHEMBL1171682 | 1.00 | KDM4E (0.71) | KDM4EALDH1A1HPGDHSD17B10CYP1A2 | |
| Pyritinol SCHEMBL27485374 | 0.98 | KDM4E (0.69) | KDM4EALDH1A1HPGDHSD17B10CYP1A2 | |
| Pyritinol SCHEMBL31418900 | 0.98 | KDM4E (0.69) | KDM4EALDH1A1HPGDHSD17B10CYP1A2 | |
| Pyritinol SCHEMBL150551 | 0.98 | KDM4E (0.73) | KDM4EALDH1A1HPGDHSD17B10CYP1A2 | |
| Pyritinol SCHEMBL30029763 | 0.98 | KDM4E (0.73) | KDM4EALDH1A1HPGDHSD17B10CYP1A2 | |
| Pyritinol SCHEMBL27694053 | 0.97 | KDM4E (0.71) | KDM4EALDH1A1HPGDHSD17B10CYP1A2 | |
| Pyritinol SCHEMBL27894712 | 0.97 | KDM4E (0.71) | KDM4EALDH1A1HPGDHSD17B10CYP1A2 | |
| Pyritinol SCHEMBL27694054 | 0.97 | KDM4E (0.71) | KDM4EALDH1A1HPGDHSD17B10CYP1A2 | |
| Pyritinol SCHEMBL28859426 | 0.97 | KDM4E (0.71) | KDM4EALDH1A1HPGDHSD17B10CYP1A2 | |
| Pyritinol SCHEMBL1171524 | 0.95 | KDM4E (0.69) | KDM4EALDH1A1HPGDHSD17B10CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 105 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118415995-B | Pyritinol hydrochloride dry suspension and preparation method thereof | 广东新众康制药有限公司 | 2025-04-04 | — | — | CN | claimed |
| CN-119264041-A | Synthesis process of pyritinol hydrochloride | 北京京丰制药(山东)有限公司 | 2025-01-07 | — | — | CN | claimed |
| CN-118846558-B | Preparation system and process of pyritinol hydrochloride | 北京京丰制药(山东)有限公司 | 2024-12-20 | — | — | CN | claimed |
| CN-118415995-A | Pyritinol hydrochloride dry suspension and preparation method thereof | 广东新众康制药有限公司 | 2024-08-02 | — | — | CN | claimed |
| CN-117797174-A | Preparation method of anti-aging medicine by umbilical cord stem cells | 浙江耶大生物医药有限公司 | 2024-04-02 | — | — | CN | claimed |
| CN-111454897-B | Domestication method for improving adaptation of mesenchymal stem cells to high-sugar environment and application of domestication method | 天晴干细胞股份有限公司 | 2023-05-09 | — | — | CN | claimed |
| CN-111454897-A | Domestication method for improving adaptation of mesenchymal stem cells to high-sugar environment and application of domestication method | 天晴干细胞股份有限公司 | 2020-07-28 | — | — | CN | claimed |
| CN-111053700-A | Metformin anti-aging skin care product | 程定超 | 2020-04-24 | — | — | CN | claimed |
| CN-101933898-A | New pyritinol hydrochloride injection | BEIJING KAWIN TECHNOLOGY SHARE HOLDING CO LTD | 2011-01-05 | — | — | CN | claimed |
| CN-101889977-A | Pyritinol hydrochloride injection and preparation method thereof | SHANDONG FANGMING PHARMACEUTICAL STOCK CO LTD | 2010-11-24 | — | — | CN | claimed |
| CN-101810614-A | Stable pyritinol hydrochloride composition for injection and preparation and preparation method thereof | HANGZHOU KANGQUANDE MEDICAL SCIENCE AND TECHNOLOGY CO LTD | 2010-08-25 | — | — | CN | claimed |
| CN-1270777-C | Addition agent of pyrithioxine hydrochloride utilized for injection | BOTAI MEDICINE SCIENCE AND TEC (CN) | 2006-08-23 | — | — | CN | claimed |
| CN-1748701-A | New method for producing pyritinol hydrochloride for injection | KAIYIN BIOLOG TECHNOLOGY CO LT (CN) | 2006-03-22 | — | — | CN | claimed |
| CN-1562008-A | Pyrithioxine hydrochloride injection and its preparing method | SHENGJITANG PHARMACEUTICAL MFG (CN) | 2005-01-12 | — | — | CN | claimed |
| CN-1491648-A | Pyrithioxine hydrochloride freeze-dried power injection and its preparing method | 熊 伟 | 2004-04-28 | — | — | CN | claimed |
| CN-1446584-A | Addition agent of pyrithioxine hydrochloride utilized for injection | BOTAI MEDICINE SCIENCE AND TEC (CN) | 2003-10-08 | — | — | CN | claimed |
| CN-118415995-B | Pyritinol hydrochloride dry suspension and preparation method thereof | 广东新众康制药有限公司 | 2025-04-04 | — | — | CN | disclosed |
| CN-118415995-B | Pyritinol hydrochloride dry suspension and preparation method thereof | 广东新众康制药有限公司 | 2025-04-04 | — | — | CN | disclosed |
| CN-1446584-A | Addition agent of pyrithioxine hydrochloride utilized for injection | BOTAI MEDICINE SCIENCE AND TEC (CN) | 2003-10-08 | — | — | CN | disclosed |
| US-4555398-A | THERMOSETTING OR THERMOPLASTIC RESIN MOLD | CHISSO CORPORATION (JP) | 1985-11-26 | — | — | US | disclosed |