Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA known ✓ | P10253 | 2/20 | 0.53 |
| ▸ | TOP2A known ✓ | P11388 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | PPID | Q08752 | 1/20 | 0.54 |
| ▸ | ELANE | P08246 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | LTA4H | P09960 | 1/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL62893 | 0.98 | POLB (0.60) | POLBPPIDGAAELANEALDH1A1 | |
| Alcohol SCHEMBL28628021 | 0.95 | POLB (0.57) | POLBPPIDGAAELANEALDH1A1 | |
| Acetic Acid SCHEMBL28661029 | 0.95 | POLB (0.57) | POLBPPIDGAAELANEALDH1A1 | |
| SCHEMBL11732203 | 0.93 | POLB (0.56) | POLBPPIDGAAELANEALDH1A1 | |
| Sulfuric Acid SCHEMBL28065986 | 0.92 | POLB (0.55) | POLBPPIDGAAELANEALDH1A1 | |
| Urethane SCHEMBL6105791 | 0.90 | POLB (0.54) | POLBPPIDGAAELANEALDH1A1 | |
| Urethane SCHEMBL7266227 | 0.90 | POLB (0.54) | POLBPPIDGAAELANEALDH1A1 | |
| Nitric Acid SCHEMBL27965379 | 0.89 | POLB (0.52) | POLBPPIDGAAELANEALDH1A1 | |
| SCHEMBL28250670 | 0.88 | POLB (0.58) | POLBPPIDGAAELANEALDH1A1 | |
| Hydrochloric Acid SCHEMBL27605421 | 0.87 | GAA (0.47) | POLBPPIDGAAELANEALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 76 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4337352-A | SALT FORMATION WITH OPTICALLY ACTIVE AMINE | BAYER AKTIENGESELLSCHAFT (DE) | 1982-06-29 | — | — | US | claimed |
| EP-0006187-B1 | SEPARATION OF ENANTIOMERS OF CHIRAL CARBOXYLIC ACIDS | BAYER AG (DE) | 1980-12-10 | — | — | EP | claimed |
| EP-0006187-A1 | Separation of enantiomers of chiral carboxylic acids | BAYER AG (DE) | 1980-01-09 | — | — | EP | claimed |
| CN-120041156-A | Kerosene phase change material with solid-liquid thixotropic reversible conversion performance | 中国科学院化学研究所 | 2025-05-27 | — | — | CN | disclosed |
| CN-118791431-A | Dihydro-isoquinolone compounds and isoindoles Selective synthesis method of pinone compound | 常州大学 | 2024-10-18 | — | — | CN | disclosed |
| CN-118359514-A | N-ester salicylamide compound and preparation method and application thereof | 湖南科技大学 | 2024-07-19 | — | — | CN | disclosed |
| CN-114409491-B | Method for preparing trans-D-dichlorochrysanthemic acid by resolution of trans-dichlorochrysanthemic acid | 中国科学院大连化学物理研究所 | 2023-02-21 | — | — | CN | disclosed |
| CN-114409491-A | Method for preparing trans-D-dichlorochrysanthemic acid by resolution of trans-dichlorochrysanthemic acid | 中国科学院大连化学物理研究所 | 2022-04-29 | — | — | CN | disclosed |
| CN-105603037-B | Method for preparing cephalosporin by enzymatic acylation | 天津大学 | 2020-07-31 | — | — | CN | disclosed |
| CN-108822133-A | The method that cefalexin is separated in the reaction product of cefalexin is prepared from enzyme process | 国药集团威奇达药业有限公司 | 2018-11-16 | — | — | CN | disclosed |
| CN-108822131-A | The method of ampicillin is separated from the reaction product of enzyme process preparation ampicillin | 国药集团威奇达药业有限公司 | 2018-11-16 | — | — | CN | disclosed |
| EP-0491477-A1 | Pyridopyridazine compounds and their use | Takeda Chemical Industries, Ltd. (JP) | 1992-06-24 | — | — | EP | disclosed |
| US-4563477-A | Process for the preparation of alpha-(N-pyrrolyl)-derivative acids, the salts and esters thereof; alpha-(N-pyrrolyl)-phenylacetic acids, the esters thereof, pharmaceutical compositions containing them and therapeutical applications thereof | ANTIBIOTICOS, S.A. (ES) | 1986-01-07 | — | — | US | disclosed |
| US-4385922-A | Method of increasing the yield of legumes utilizing D- or DL-α-O,O-diethlyphosphorodithioylacetylphenylglycine ethyl esters | STAUFFER CHEMICAL COMPANY (US) | 1983-05-31 | — | — | US | disclosed |
| US-4337352-A | SALT FORMATION WITH OPTICALLY ACTIVE AMINE | BAYER AKTIENGESELLSCHAFT (DE) | 1982-06-29 | — | — | US | disclosed |
| EP-0006187-B1 | SEPARATION OF ENANTIOMERS OF CHIRAL CARBOXYLIC ACIDS | BAYER AG (DE) | 1980-12-10 | — | — | EP | disclosed |
| EP-0006187-A1 | Separation of enantiomers of chiral carboxylic acids | BAYER AG (DE) | 1980-01-09 | — | — | EP | disclosed |
| US-4136180-A | HYPOLIPIDEMIC SUBSTITUTED STYRENESULFONYLUREAS | PFIZER INC. (US) | 1979-01-23 | — | — | US | disclosed |
| US-4062960-A | Hypolipidemic alkenesulfonamides | PFIZER INC. (US) | 1977-12-13 | — | — | US | disclosed |
| US-3983107-A | ARTERIOSCLEROSIS | PFIZER INC. (US) | 1976-09-28 | — | — | US | disclosed |