SCHEMBL15599174

SCHEMBL15599174

CC(C)c1cnc(C(C)C)c(Cl)c1

nearest known ligand 0.34

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 2/20 0.34
GLP1R P43220 2/20 0.33
MEN1 O00255 1/20 0.33
MAPK1 P28482 1/20 0.32
EIF4A3 P38919 1/20 0.31
SMN1; SMN2 Q16637 2/20 0.31
NPBWR1 P48145 2/20 0.31
MCHR1 Q99705 2/20 0.31
RAB9A P51151 1/20 0.31
GAA P10253 1/20 0.31
L3MBTL1 Q9Y468 1/20 0.30
S1PR1 P21453 1/20 0.30
S1PR3 Q99500 1/20 0.30
LMNA P02545 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10028338 0.80 ALDH1A1 (0.41) KMT2AEIF4A3
SCHEMBL2609312 0.80 LMNA (0.44) KMT2AGLP1RMEN1MAPK1SMN1; SMN2
SCHEMBL12248259 0.78 CCR1 (0.35) KMT2AGLP1RMAPK1SMN1; SMN2RAB9A
SCHEMBL12144347 0.78 CHRNB2 (0.40) EIF4A3SMN1; SMN2RAB9ALMNA
SCHEMBL17486765 0.77 RXRA (0.31) EIF4A3
SCHEMBL84363 0.77 CPB2 (0.36)
SCHEMBL21139639 0.77 KMT2A (0.36) KMT2AGLP1RMEN1MAPK1SMN1; SMN2
SCHEMBL16139588 0.77 S1PR1 (0.42) KMT2AGLP1RMEN1SMN1; SMN2RAB9A
SCHEMBL17486767 0.77 RXRA (0.31) EIF4A3
SCHEMBL14558312 0.77 SMN1; SMN2 (0.37) EIF4A3SMN1; SMN2RAB9AGAALMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230373969-A1 MK2 INHIBITORS AND USES THEREOF XINTHERA, INC. 2023-11-23 US disclosed
US-20230373969-A1 MK2 INHIBITORS AND USES THEREOF XINTHERA, INC. 2023-11-23 US disclosed
US-20230265076-A1 MK2 INHIBITORS AND USES THEREOF XINTHERA, INC. 2023-08-24 US disclosed
US-20230265076-A1 MK2 INHIBITORS AND USES THEREOF XINTHERA, INC. 2023-08-24 US disclosed
US-11680056-B2 MK2 inhibitors and uses thereof XINTHERA, INC. (US) 2023-06-20 US disclosed
US-20230141913-A2 PHENOXY(HETERO)ARYL ETHERS OF ANTIPROLIFERACTIVE ACTIVITY Xeniopro GmbH (DE) 2023-05-11 US disclosed
US-20220402892-A1 MK2 INHIBITORS AND USES THEREOF XINTHERA, INC. 2022-12-22 US disclosed
US-20210253577-A1 BIODEFENSE AGENTS BioVersys AG (CH) 2021-08-19 US disclosed
US-20210106568-A1 DIARYL SUBSTITUTED 6,5-FUSED RING COMPOUNDS AS C5aR INHIBITORS CHEMOCENTRYX, INC. 2021-04-15 US disclosed
US-20210052612-A1 PRODRUGS OF FUSED-BICYCLIC C5aR ANTAGONISTS CHEMOCENTRYX, INC. 2021-02-25 US disclosed
US-10815237-B2 Antimicrobials and methods of making and using same BioVersys AG (CH) 2020-10-27 US disclosed
US-20190194205-A1 ANTIMICROBIALS AND METHODS OF MAKING AND USING SAME MELINTA THERAPEUTICS, INC. 2019-06-27 US disclosed
US-9550775-B2 Substituted triazolopyridines and methods of use thereof GENENTECH, INC. (US) 2017-01-24 US disclosed
US-9550775-B2 Substituted triazolopyridines and methods of use thereof GENENTECH, INC. (US) 2017-01-24 US disclosed
US-9493429-B2 Substituted benzoxazoles and methods of use thereof GENENTECH, INC. (US) 2016-11-15 US disclosed
US-20160009710-A1 SUBSTITUTED TRIAZOLOPYRIDINES AND METHODS OF USE THEREOF XENON PHARMACEUTICALS INC. (CA) 2016-01-14 US disclosed
US-20160009667-A1 SUBSTITUTED BENZOXAZOLES AND METHODS OF USE THEREOF GENENTECH, INC. (US) 2016-01-14 US disclosed
US-20150322002-A1 N-SUBSTITUTED BENZAMIDES AND METHODS OF USE THEREOF GENENTECH, INC. (US) 2015-11-12 US disclosed
WO-2014008458-A2 N-SUBSTITUTED BENZAMIDES AND METHODS OF USE THEREOF GENENTECH, INC. (US) 2014-01-09 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (13 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150322002-A1 N-SUBSTITUTED BENZAMIDES AND METHODS OF USE THEREOF BRIX1, SNRPD2, RDX KMT2A 1496/4885GLP1R 575/4885MEN1 1720/4885
US-20190194205-A1 ANTIMICROBIALS AND METHODS OF MAKING AND USING SAME LPO, OAT, MPO KMT2A 4626/4885GLP1R 1950/4885MEN1 2640/4885
US-10815237-B2 Antimicrobials and methods of making and using same LPO, OAT, MPO KMT2A 4626/4885GLP1R 1950/4885MEN1 2640/4885
US-20230373969-A1 MK2 INHIBITORS AND USES THEREOF MKNK2, ENPP2, MAPKAPK2 KMT2A 325/4885GLP1R 4022/4885MEN1 850/4885
US-11680056-B2 MK2 inhibitors and uses thereof MKNK2, ENPP2, MAPKAPK2 KMT2A 325/4885GLP1R 4022/4885MEN1 850/4885
US-20230265076-A1 MK2 INHIBITORS AND USES THEREOF MKNK2, ENPP2, MAPKAPK2 KMT2A 325/4885GLP1R 4022/4885MEN1 850/4885
US-20210052612-A1 PRODRUGS OF FUSED-BICYCLIC C5aR ANTAGONISTS C5AR2, C5AR1, C3AR1 KMT2A 4404/4885GLP1R 1637/4885MEN1 2135/4885
US-20220402892-A1 MK2 INHIBITORS AND USES THEREOF MKNK2, ENPP2, MAPKAPK2 KMT2A 263/4885GLP1R 4238/4885MEN1 891/4885
US-20160009710-A1 SUBSTITUTED TRIAZOLOPYRIDINES AND METHODS OF USE THEREOF P2RX3, P2RX1, P2RX4 KMT2A 3498/4885GLP1R 319/4885MEN1 2038/4885
US-20160009667-A1 SUBSTITUTED BENZOXAZOLES AND METHODS OF USE THEREOF CYP4X1, BRIX1, HAX1 KMT2A 2561/4885GLP1R 236/4885MEN1 2674/4885
US-20230141913-A2 PHENOXY(HETERO)ARYL ETHERS OF ANTIPROLIFERACTIVE ACTIVITY AHR, MUSK, TYR KMT2A 762/4885GLP1R 4449/4885MEN1 4794/4885
US-20210253577-A1 BIODEFENSE AGENTS BPGM, DDT, UNG KMT2A 4310/4885GLP1R 4761/4885MEN1 3962/4885
US-20210106568-A1 DIARYL SUBSTITUTED 6,5-FUSED RING COMPOUNDS AS C5aR INHIBITORS C5AR1, C5AR2, C3AR1 KMT2A 4588/4885GLP1R 1052/4885MEN1 1288/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.