SCHEMBL1642428

SCHEMBL1642428

B[C@@H]1O[C@H](COC)C(OP(C)(=O)O)[C@@H]1OCCCN

nearest known ligand 0.31

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ ITPR3 Q14573 1/20 0.30
▸ ITPR1 Q14643 1/20 0.30
▸ SSTR1 P30872 1/20 0.30
▸ SSTR2 P30874 1/20 0.30
▸ SSTR4 P31391 1/20 0.30
▸ SSTR3 P32745 1/20 0.30
▸ SSTR5 P35346 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10005839 1.00 ITPR3 (0.30) ITPR3ITPR1SSTR1SSTR2SSTR4
SCHEMBL19608814 1.00 ITPR3 (0.30) ITPR3ITPR1SSTR1SSTR2SSTR4
SCHEMBL19768566 0.93 IGF2R (0.35) —
SCHEMBL1644129 0.89 — —
SCHEMBL19608817 0.89 — —
SCHEMBL10005842 0.89 — —
SCHEMBL10005840 0.89 — —
SCHEMBL1642430 0.89 — —
SCHEMBL12674234 0.89 — —
SCHEMBL19577793 0.88 SSTR1 (0.30) SSTR1SSTR2SSTR4SSTR3SSTR5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 104 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240067965-A1 ORAL DELIVERY OF ANTISENSE CONJUGATES TARGETING PCSK9 CIVI BIOPHARMA INC (US) 2024-02-29 — — US disclosed
US-20230304014-A1 MIRNA-485 INHIBITOR FOR HUNTINGTON'S DISEASE BIORCHESTRA CO., LTD. (KR) 2023-09-28 — — US disclosed
US-11702652-B2 Enzymatic encoding methods for efficient synthesis of large libraries NUEVOLUTION A/S (DK) 2023-07-18 — — US disclosed
US-20230126157-A1 MIRNA-485 INHIBITOR FOR GENE UPREGULATION BIORCHESTRA CO., LTD. (KR) 2023-04-27 — — US disclosed
US-20180161356-A1 TAU ANTISENSE OLIGOMERS AND USES THEREOF ROCHE INNOVATION CENTER COPENHAGEN A/S (DK) 2018-06-14 — — US disclosed
US-20180112217-A1 Stereospecific Phosphorothioate LNA ROCHE INNOVATION CENTER COPENHAGEN A/S (DK) 2018-04-26 — — US disclosed
US-9885035-B2 Method for the synthesis of a bifunctional complex NUEVOLUTION A/S (DK) 2018-02-06 — — US disclosed
US-9879265-B2 Oligonucleotide conjugates ROCHE INNOVATION CENTER COPENHAGEN A/S (DK) 2018-01-30 — — US disclosed
US-20170349896-A1 POLY OLIGOMER COMPOUND WITH BIOCLEAVABLE CONJUGATES ROCHE INNOVATION CENTER COPENHAGEN A/S (DK) 2017-12-07 — — US disclosed
US-20170335323-A1 Chiral Library Screen ROCHE INNOVATION CENTER COPENHAGEN A/S (CH) 2017-11-23 — — US disclosed
US-20090264300-A1 ENZYMATIC ENCODING METHODS FOR EFFICIENT SYNTHESIS OF LARGE LIBRARIES NUEVOLUTION A/S (DK) 2009-10-22 — — US disclosed
US-20090239211-A1 Method For Enrichment Involving Elimination By Mismatch Hybridisation NUEVOLUTION A/S (DK) 2009-09-24 — — US disclosed
US-20090202573-A1 POLYMERIC CONJUGATES CONTAINING POSITIVELY-CHARGED MOIETIES ENZON PHARMACEUTICALS, INC. (US) 2009-08-13 — — US disclosed
US-20090203137-A1 COMPOUNDS FOR THE MODULATION OF BETA-CATENIN EXPRESSION SANTARIS PHARMA A/S (DK) 2009-08-13 — — US disclosed
US-20090181916-A1 LNA ANTAGONISTS TARGETING THE ANDROGEN RECEPTOR SANTARIS PHARMA A/S (DK) 2009-07-16 — — US disclosed
US-20090143232-A1 METHOD FOR SYNTHESISING TEMPLATED MOLECULES NUEVOLUTION A/S (DK) 2009-06-04 — — US disclosed
US-20090118213-A1 RNA ANTAGONIST COMPOUNDS FOR THE INHIBITION OF APO-B100 EXPRESSION SANTARIS PHARMA A/S (DK) 2009-05-07 — — US disclosed
US-7413854-B2 Method for synthesising templated molecules NUEVOLUTION A/S (DK) 2008-08-19 — — US disclosed
US-20080188432-A1 Short nucleotide subsequences located within number 15; such as locked nucleic acids antisense oligonucleotides; biostability, cell permeability; anticancer agents SANTARIS PHARMA A/S (DK) 2008-08-07 — — US disclosed
US-20070026397-A1 Method for producing second-generation library NUEVOLUTION A/S (DK) 2007-02-01 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090264300-A1 ENZYMATIC ENCODING METHODS FOR EFFICIENT SYNTHESIS OF LARGE LIBRARIES RNGTT, DUT, EMG1 ITPR3 3088/4885ITPR1 2843/4885SSTR1 4283/4885
US-20090118213-A1 RNA ANTAGONIST COMPOUNDS FOR THE INHIBITION OF APO-B100 EXPRESSION RNASE1, APOB, SERPINB10 ITPR3 3230/4885ITPR1 2750/4885SSTR1 2115/4885
US-20230126157-A1 MIRNA-485 INHIBITOR FOR GENE UPREGULATION NRP1, SORT1, NR4A3 ITPR3 4409/4885ITPR1 4095/4885SSTR1 1063/4885
US-20180161356-A1 TAU ANTISENSE OLIGOMERS AND USES THEREOF MAPT, FUS, TARDBP ITPR3 2958/4885ITPR1 3626/4885SSTR1 4041/4885
US-20080188432-A1 Short nucleotide subsequences located within number 15; such as locked nucleic acids antisense oligonucleotides; biostability, cell permeability; anticancer agents HRAS, KRAS, RNASE1 ITPR3 2039/4885ITPR1 1955/4885SSTR1 907/4885
US-20090203137-A1 COMPOUNDS FOR THE MODULATION OF BETA-CATENIN EXPRESSION CTNNB1, CTNNA1, WNT1 ITPR3 3597/4885ITPR1 3674/4885SSTR1 4837/4885
US-20230304014-A1 MIRNA-485 INHIBITOR FOR HUNTINGTON'S DISEASE HTT, HIPK1, HIPK4 ITPR3 4464/4885ITPR1 3932/4885SSTR1 3580/4885
US-20090181916-A1 LNA ANTAGONISTS TARGETING THE ANDROGEN RECEPTOR AR, ESRRB, ESRRA ITPR3 3646/4885ITPR1 3812/4885SSTR1 414/4885
US-20090202573-A1 POLYMERIC CONJUGATES CONTAINING POSITIVELY-CHARGED MOIETIES PIGO, PHOSPHO1, PAICS ITPR3 361/4885ITPR1 754/4885SSTR1 2950/4885
US-20240067965-A1 ORAL DELIVERY OF ANTISENSE CONJUGATES TARGETING PCSK9 PCSK9, SCD5, PCSK7 ITPR3 2236/4885ITPR1 2812/4885SSTR1 3863/4885
US-20090143232-A1 METHOD FOR SYNTHESISING TEMPLATED MOLECULES FGB, ILK, TBCB ITPR3 3810/4885ITPR1 4027/4885SSTR1 3916/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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