Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Thiophene Carboxylic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Thiophene Carboxylic Acid SCHEMBL83000 | 0.97 | — | — | |
| Thiophene Carboxylic Acid SCHEMBL27774764 | 0.97 | DAO (1.00) | — | |
| Thiophene Carboxylic Acid SCHEMBL7062244 | 0.97 | DAO (1.00) | — | |
| Thiophene Carboxylic Acid SCHEMBL10898170 | 0.95 | — | — | |
| Thiophene Carboxylic Acid SCHEMBL20895852 | 0.95 | — | — | |
| Thiophene Carboxylic Acid SCHEMBL5287669 | 0.95 | DAO (0.95) | — | |
| Thiophene Carboxylic Acid SCHEMBL4331473 | 0.95 | — | — | |
| Thiophene Carboxylic Acid SCHEMBL116447 | 0.95 | — | — | |
| Thiophene Carboxylic Acid SCHEMBL9550536 | 0.95 | — | — | |
| Thiophene Carboxylic Acid SCHEMBL11452200 | 0.95 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 294 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103796992-B | Guanidinobenzoic acid compound | ASTELLAS PHARMA INC. (JP) | 2016-04-27 | — | — | CN | claimed |
| US-7034154-B2 | Synthesis of substituted pyrazolopyrimidines | NEUROCRINE BIOSCIENCES, INC. (US) | 2006-04-25 | — | — | US | claimed |
| EP-1208102-B1 | SYNTHESIS OF A SUBSTITUTED PYRAZOLOPYRIMIDINE | NEUROCRINE BIOSCIENCES INC (US) | 2003-03-26 | — | — | EP | claimed |
| JP-2003506453-A | — | — | 2003-02-18 | — | — | JP | claimed |
| US-20030004346-A1 | Synthesis of substituted pyrazolopyrimidines | NEUROCRINE BIOSCIENCES, INC. (US) | 2003-01-02 | — | — | US | claimed |
| US-6472528-B1 | TREATING CONDITIONS WHICH BENEFIT FROM ADMINISTRATION OF AGENTS WHICH POSSESS ANXIOLYTIC, ANTI-ANOXIC, SLEEP-INDUCING, HYPNOTIC, ANTICONVULSANT, AND/OR SKELETAL MUSCLE RELAXANT PROPERTIES. SUCH CONDITIONS INCLUDE INSOMNIA | NEUROCRINE BIOSCIENCES, INC. | 2002-10-29 | — | — | US | claimed |
| EP-1208102-A1 | SYNTHESIS OF SUBSTITUTED PYRAZOLOPYRIMIDINES | Neurocrine Biosciences, Inc. (US) | 2002-05-29 | — | — | EP | claimed |
| WO-2001010868-A1 | SYNTHESIS OF SUBSTITUTED PYRAZOLOPYRIMIDINES | NEUROCRINE BIOSCIENCES, INC. (US) | 2001-02-15 | — | — | WO | claimed |
| US-6013664-A | REACTING THIOPHENE-2-CARBOXYLIC ACID DERIVATIVE WITH AMINE, HYDROXY OR MERCAPTO DERIVATIVES | BAYER AKTIENGESELLSCHAFT (DE) | 2000-01-11 | — | — | US | claimed |
| EP-0219747-B1 | 2-(2-THIENYL)-IMIDAZO(4,5-C)PYRIDINE DERIVATIVES AND THEIR SALTS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM | CL PHARMA AKTIENGESELLSCHAFT (AT) | 1990-05-16 | — | — | EP | claimed |
| US-4234737-A | Process for preparing thienylglyoxylic acids and amides | STAUFFER CHEMICAL COMPANY (US) | 1980-11-18 | — | — | US | claimed |
| JP-6298760-A | — | — | None | — | — | JP | disclosed |
| US-12624004-B2 | Opioid receptor agonist, preparation method therefor and pharmaceutical use thereof | FUDAN UNIVERSITY (CN) | 2026-05-12 | — | — | US | disclosed |
| EP-4665733-A1 | AMINO-SUBSTITUTED PYRROLOTRIAZINE DERIVATIVES AS INHIBITORS OF SGK1 | Bristol-Myers Squibb Company (US) | 2025-12-24 | — | — | EP | disclosed |
| WO-2024199395-A1 | OXIME ESTER PHOTOINITIATOR, PHOTOCURABLE RESIN COMPOSITION AND USE | 常州强力先端电子材料有限公司 | 2024-10-03 | — | — | WO | disclosed |
| US-3969508-A | 4-(2-THENOYL)-2,3-DICHLORO-PHENOXYACETIC ACID | SMITHKLINE CORPORATION (US) | 1976-07-13 | — | — | US | disclosed |
| US-3969529-A | Phenoxyacetic acid derivatives as diuretic agents | C.E.R.P.H.A. (FR) | 1976-07-13 | — | — | US | disclosed |
| US-3966938-A | Treatment of thrombosis and the inhibition of blood platelet aggregation | SANDOZ LTD. (CH) | 1976-06-29 | — | — | US | disclosed |
| US-3952012-A | MULTISTAGE | MCNEIL LABORATORIES, INCORPORATED (US) | 1976-04-20 | — | — | US | disclosed |
| US-3950347-A | NAPHTHOLACTAM DYESTUFFS | BAYER AKTIENGESELLSCHAFT (DT) | 1976-04-13 | — | — | US | disclosed |