Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Thiamine Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 known ✓ | P07900 | 1/20 | 0.98 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.67 |
| ▸ | TKT | P29401 | 12/20 | 0.67 |
| ▸ | LMNA | P02545 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Thiamine Ion SCHEMBL23290122 | 1.00 | HSP90AA1 (0.98) | HSP90AA1TDP1KDM4ETKTLMNA | |
| Thiamine Ion SCHEMBL5520463 | 1.00 | HSP90AA1 (0.98) | HSP90AA1TDP1KDM4ETKTLMNA | |
| Thiamine Ion SCHEMBL30028012 | 0.99 | HSP90AA1 (0.95) | HSP90AA1TDP1KDM4ETKTLMNA | |
| Thiamine Ion SCHEMBL5317564 | 0.99 | HSP90AA1 (0.95) | HSP90AA1TDP1KDM4ETKTLMNA | |
| Thiamine Ion SCHEMBL29130296 | 0.99 | HSP90AA1 (0.95) | HSP90AA1TDP1KDM4ETKTLMNA | |
| Thiamine Ion SCHEMBL7200449 | 0.99 | HSP90AA1 (0.95) | HSP90AA1TDP1KDM4ETKTLMNA | |
| Thiamine Ion SCHEMBL28524160 | 0.99 | HSP90AA1 (0.95) | HSP90AA1TDP1KDM4ETKTLMNA | |
| Thiamine Ion SCHEMBL1704946 | 0.99 | HSP90AA1 (0.95) | HSP90AA1TDP1KDM4ETKTLMNA | |
| Thiamine Ion SCHEMBL1251742 | 0.99 | HSP90AA1 (0.95) | HSP90AA1TDP1KDM4ETKTLMNA | |
| Thiamine Ion SCHEMBL10534682 | 0.99 | HSP90AA1 (0.95) | HSP90AA1TDP1KDM4ETKTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1521 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230189865-A1 | INFANT FORMULA | ENCHANTED ACRES FARMS INC (US) | 2023-06-22 | — | — | US | claimed |
| EP-4149278-A1 | INFANT FORMULA | Enchanted Acres Farm, Inc. (US) | 2023-03-22 | — | — | EP | claimed |
| WO-2021231981-A1 | INFANT FORMULA | ENCHANTED ACRES FARM, INC. (US) | 2021-11-18 | — | — | WO | claimed |
| CN-108690825-B | Serum-free medium for protecting integrity of antibody disulfide bonds in animal cell culture | 上海倍谙基生物科技有限公司 | 2021-08-17 | — | — | CN | claimed |
| US-10124036-B2 | Liquid nutritional formula for tyrosinemia patients | Cambrooke Therapeutics, Inc. (US) | 2018-11-13 | — | — | US | claimed |
| CN-108464491-A | A kind of emulsion stabilizer and the pancebrin containing the emulsion stabilizer | 广州白云山汉方现代药业有限公司 | 2018-08-31 | — | — | CN | claimed |
| CN-108243955-A | A kind of abductive approach of callus | 康美药业（文山）药材种植管理有限公司 | 2018-07-06 | — | — | CN | claimed |
| CN-108064692-A | A kind of abductive approach of Radix Notoginseng anther callus | 康美药业（文山）药材种植管理有限公司 | 2018-05-25 | — | — | CN | claimed |
| US-20180064784-A9 | LIQUID NUTRITIONAL FORMULA FOR TYROSINEMIA PATIENTS | Cambrooke Therapeutics, Inc. (US) | 2018-03-08 | — | — | US | claimed |
| EP-2776834-B1 | METHOD OF IDENTIFYING PREBIOTICS AND COMPOSITIONS CONTAINING THE SAME | PROCTER & GAMBLE (US) | 2018-02-21 | — | — | EP | claimed |
| US-20070092546-A1 | Thiamin based insect repellant | VIOLET FIRE, LLC | 2007-04-26 | — | — | US | claimed |
| CN-1284522-C | Glucose and insulin liquid compositions for intravenous infusion | HANAMARADDI T GANGAL (IN) | 2006-11-15 | — | — | CN | claimed |
| US-20050260305-A1 | Food supplement with separate flavoring system | EAT-SMART, LLC | 2005-11-24 | — | — | US | claimed |
| US-20050118671-A1 | Analysis of vital substances | BIOTESYS GMBH (DE) | 2005-06-02 | — | — | US | claimed |
| US-6838097-B1 | Pet food product | DOSKOCIL MANUFACTURING COMPANY, INC. | 2005-01-04 | — | — | US | claimed |
| CN-1387794-A | Health table salt | YUE JING (CN) | 2003-01-01 | — | — | CN | claimed |
| EP-1185685-A1 | CULTURE MEDIUM FOR THE DETECTION OF ZYGOSACCHAROMYCES | Stab Vida-Investigacao e Servicos EM Ciencias Biologicas, Lda. (PT) | 2002-03-13 | — | — | EP | claimed |
| WO-2000073494-B1 | CULTURE MEDIUM FOR THE DETECTION OF ZYGOSACCHAROMYCES | UNIV DO MINHO (PT) | 2001-02-08 | — | — | WO | claimed |
| WO-2000073494-A1 | CULTURE MEDIUM FOR THE DETECTION OF ZYGOSACCHAROMYCES | UNIVERSIDADE DO MINHO (PT) | 2000-12-07 | — | — | WO | claimed |
| WO-2000062812-A1 | NUTRITIONAL COMPOSITION FOR IMPROVED COGNITIVE PERFORMANCE | ADVOCARE INTERNATIONAL LLC (US) | 2000-10-26 | — | — | WO | claimed |