Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 known ✓ | P03372 | 4/20 | 0.35 |
| ▸ | ESR2 known ✓ | Q92731 | 4/20 | 0.35 |
| ▸ | GAA known ✓ | P10253 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8513422 | 1.00 | CYP3A4 (0.45) | CYP3A4TDP1ESR1ESR2CALM1 | |
| SCHEMBL1705969 | 0.97 | CYP3A4 (0.47) | CYP3A4TDP1ESR1ESR2CALM1 | |
| Hydrochloric Acid SCHEMBL5081299 | 0.97 | CYP3A4 (0.47) | CYP3A4TDP1ESR1ESR2CALM1 | |
| Hydrochloric Acid SCHEMBL30288225 | 0.97 | CYP3A4 (0.47) | CYP3A4TDP1ESR1ESR2CALM1 | |
| SCHEMBL956408 | 0.97 | CYP3A4 (0.47) | CYP3A4TDP1ESR1ESR2CALM1 | |
| Hydrochloric Acid SCHEMBL8623596 | 0.94 | CYP3A4 (0.45) | CYP3A4TDP1ESR1ESR2CALM1 | |
| Hydrochloric Acid SCHEMBL8488594 | 0.94 | CYP3A4 (0.45) | CYP3A4TDP1ESR1ESR2CALM1 | |
| SCHEMBL27343 | 0.94 | CYP3A4 (0.50) | CYP3A4TDP1ESR1ESR2CALM1 | |
| Phosphine SCHEMBL25423478 | 0.91 | CYP3A4 (0.47) | CYP3A4TDP1ESR1ESR2CALM1 | |
| SCHEMBL9803502 | 0.91 | CYP3A4 (0.47) | CYP3A4TDP1ESR1ESR2CALM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 188 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022252789-A1 | METHOD FOR PREPARING JAK INHIBITOR KEY INTERMEDIATE | 山东莱福科技发展有限公司 | 2022-12-08 | — | — | WO | claimed |
| EP-3275881-B1 | COMPOUND OF 5-HYDROXYL-1,7-NAPHTHYRIDINE SUBSTITUTED BY ARYLOXY OR HETEROOXY, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE THEREOF | SHENYANG SUNSHINE PHARMACEUTICAL CO LTD (CN) | 2021-08-04 | — | — | EP | claimed |
| US-10100051-B2 | Compound of 5-hydroxyl-1,7-naphthyridine substituted by aryloxy or heteroaryloxy, preparation method thereof and pharmaceutical use thereof | SHENYANG SUNSHINE PHARMACEUTICAL CO. LTD. (CN) | 2018-10-16 | — | — | US | claimed |
| US-20180118739-A1 | COMPOUND OF 5-HYDROXYL-1,7-NAPHTHYRIDINE SUBSTITUTED BY ARYLOXY OR HETEROARYLOXY, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE THEREOF | SHENYANG SUNSHINE PHARMACEUTICAL CO., LTD. (CN) | 2018-05-03 | — | — | US | claimed |
| EP-3275881-A1 | COMPOUND OF 5-HYDROXYL-1,7-NAPHTHYRIDINE SUBSTITUTED BY ARYLOXY OR HETEROOXY, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE THEREOF | Shenyang Sunshine Pharmaceutical Co., Ltd. (CN) | 2018-01-31 | — | — | EP | claimed |
| EP-2083033-B1 | Organic semiconducting copolymer and organic electronic device including the same | SAMSUNG ELECTRONICS CO LTD (KR) | 2012-04-18 | — | — | EP | claimed |
| US-7777221-B2 | Organic semiconducting copolymer and organic electronic device including the same | SAMSUNG ELECTRONICS CO., LTD. (KR) | 2010-08-17 | — | — | US | claimed |
| US-20090189150-A1 | Organic semiconducting copolymer and organic electronic device including the same | SAMSUNG ELECTRONICS CO., LTD. | 2009-07-30 | — | — | US | claimed |
| EP-2083033-A1 | Organic semiconducting copolymer and organic electronic device including the same | Samsung Electronics Co., Ltd. (KR) | 2009-07-29 | — | — | EP | claimed |
| US-RE40813-E1 | Polythiophenes, block copolymers made therefrom, and methods of forming the same | CARNEGIE MELLON UNIVERSITY (US) | 2009-06-30 | — | — | US | claimed |
| US-20060155105-A1 | Halogenated thiophene monomer for the preparation of regioregular polythiophenes | HONEYWELL INTERNATIONAL INC. | 2006-07-13 | — | — | US | claimed |
| US-20060155134-A1 | Process for the kumada coupling reaction | HONEYWELL INTERNATIONAL INC. | 2006-07-13 | — | — | US | claimed |
| EP-1028136-B1 | A method of forming poly-(3-substituted) thiophenes | UNIV CARNEGIE MELLON (US) | 2006-05-24 | — | — | EP | claimed |
| US-20050080219-A1 | Process of preparing regioregular polymers | MERCK PATENT GMBH (DE) | 2005-04-14 | — | — | US | claimed |
| US-20040030091-A1 | Lightweight, electroconductivity, heat resistance | MCCULLOUGH RICHARD D (US) | 2004-02-12 | — | — | US | claimed |
| US-20040024171-A1 | Stereospecific electroconductive polymers such as polyhexylthiophene-polystyrene or -polymethylacrylate copolymers, used as light emitting diodes, biosensors, transistors, displays or optical apparatus | MCCULLOUGH RICHARD D (US) | 2004-02-05 | — | — | US | claimed |
| US-6602974-B1 | Conducting polymers, head-to-tail coupled regioregular polythiophenes, poly-(3-substituted) thiophene diol | CARNEGIE MELLON UNIVERSITY | 2003-08-05 | — | — | US | claimed |
| US-6166172-A | Method of forming poly-(3-substituted) thiophenes | CARNEGIE MELLON UNIVERSITY (US) | 2000-12-26 | — | — | US | claimed |
| EP-1028136-A2 | A method of forming poly-(3-substituted) thiophenes | CARNEGIE-MELLON UNIVERSITY (US) | 2000-08-16 | — | — | EP | claimed |
| US-5874628-A | Method for preparation of tertiary phosphines via nickel-catalyzed cross coupling | MONSANTO COMPANY (US) | 1999-02-23 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180118739-A1 | COMPOUND OF 5-HYDROXYL-1,7-NAPHTHYRIDINE SUBSTITUTED BY ARYLOXY OR HETEROARYLOXY, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE THEREOF | HIF1AN, EGLN3, EGLN2 | ESR1 249/4885ESR2 160/4885GAA 1071/4885 |
| US-10100051-B2 | Compound of 5-hydroxyl-1,7-naphthyridine substituted by aryloxy or heteroaryloxy, preparation method thereof and pharmaceutical use thereof | HIF1AN, EGLN3, EGLN2 | ESR1 249/4885ESR2 160/4885GAA 1071/4885 |
| US-20060155134-A1 | Process for the kumada coupling reaction | KMT5A, KMT5C, KCNT1 | ESR1 3928/4885ESR2 4279/4885GAA 4260/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.