Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DTYMK | P23919 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | CASP6 | P55212 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CTSD | P07339 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | DNA2 | P51530 | 1/20 | 0.38 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.37 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7560618 | 0.85 | TSHR (0.46) | DTYMKTSHRCASP6ALDH1A1POLB | |
| SCHEMBL4292385 | 0.80 | SIRT6 (0.46) | TSHRALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL57882 | 0.76 | TSHR (0.40) | TSHRCASP6ALDH1A1POLBMEN1 | |
| SCHEMBL158733 | 0.75 | GPR35 (0.47) | TSHRALDH1A1POLBMEN1KMT2A | |
| SCHEMBL13835837 | 0.74 | CYP1A2 (0.51) | TSHRCASP6ALDH1A1MEN1KMT2A | |
| SCHEMBL490677 | 0.73 | ALDH1A1 (0.48) | TSHRALDH1A1POLBMEN1KMT2A | |
| SCHEMBL27991513 | 0.73 | L3MBTL1 (0.48) | TSHRALDH1A1POLBMAPTLMNA | |
| SCHEMBL7013577 | 0.73 | LMNA (0.44) | TSHRCASP6ALDH1A1POLBMEN1 | |
| SCHEMBL29696138 | 0.72 | TSHR (0.67) | DTYMKTSHRALDH1A1MEN1KMT2A | |
| SCHEMBL30727560 | 0.72 | TSHR (0.67) | DTYMKTSHRALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 359 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240197898-A1 | SUBSTITUTED BENZO[5,6][1,4]DIAZEPINO[1,2-a]INDOLES FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | IMMUNOGEN, INC. | 2024-06-20 | — | — | US | claimed |
| US-11793885-B2 | Substituted benzo[5,6][1,4]diazepino[1,2-a]indoles for the treatment of proliferative disorders | IMMUNOGEN, INC. (US) | 2023-10-24 | — | — | US | claimed |
| CN-116514903-A | Cytotoxic benzodiazepine derivatives | 伊缪诺金公司 | 2023-08-01 | — | — | CN | claimed |
| US-20230233697-A1 | CYTOTOXIC BENZODIAZEPINE DERIVATIVES | IMMUNOGEN, INC. | 2023-07-27 | — | — | US | claimed |
| US-20230094471-A1 | CYTOTOXIC BIS-BENZODIAZEPINE DERIVATIVES AND CONJUGATES THEREOF WITH CELL-BINDING AGENTS FOR INHIBITING ABNORMAL CELL GROWTH OR FOR TREATING PROLIFERATIVE DISEASES | IMMUNOGEN, INC. (US) | 2023-03-30 | — | — | US | claimed |
| CN-110229658-B | In-situ generated copper nanocluster with double-layer shell structure and preparation method and application thereof | 浙江师范大学 | 2022-11-15 | — | — | CN | claimed |
| EP-3947395-A1 | CYTOTOXIC BIS-BENZODIAZEPINE DERIVATIVES AND CONJUGATES THEREOF WITH CELL-BINDING AGENTS FOR INHIBITING ABNORMAL CELL GROWTH OR FOR TREATING PROLIFERATIVE DISEASES | ImmunoGen, Inc. (US) | 2022-02-09 | — | — | EP | claimed |
| CN-113661172-A | Cytotoxic bis-benzodiazepine derivatives and conjugates thereof with cell-binding agents for use in inhibiting abnormal cell growth or treating proliferative diseases | 伊缪诺金公司 | 2021-11-16 | — | — | CN | claimed |
| US-20210170037-A1 | BRANCHED SUGAR ALCOHOL-BASED COMPOUNDS, AND COMPOSITIONS AND METHODS THEREOF | CELLMOSAIC INC (US) | 2021-06-10 | — | — | US | claimed |
| EP-3486248-B1 | IMPROVED METHODS FOR THE ACYLATION OF MAYTANSINOL | IMMUNOGEN INC (US) | 2021-04-07 | — | — | EP | claimed |
| US-20030055226-A1 | Methods for preparation of cytotoxic conjugates of maytansinoids and cell binding agents | IMMUNOGEN, INC. | 2003-03-20 | — | — | US | claimed |
| WO-2002098883-A1 | METHODS FOR PREPARATION OF CYTOTOXIC CONJUGATES OF MAYTANSINOIDS AND CELL BINDING AGENTS | IMMUNOGEN, INC. (US) | 2002-12-12 | — | — | WO | claimed |
| US-6441163-B1 | COUPLING MAYTANSINOIDS HAVING DISULFIDE LINKER BEARING REACTIVE MOIETY TO SUCH AS ANTIBODIES WITHOUT PRIOR MODIFICATION OF SAID ANTIBODY; ONE-STEP, HIGH YIELD, LOWER COST | IMMUNOGEN, INC. | 2002-08-27 | — | — | US | claimed |
| US-5663242-A | End-attachment of oligonucleotides to polyacrylamide solid supports for capture and detection of nucleic acids | SISKA DIAGNOSTICS, INC. (US) | 1997-09-02 | — | — | US | claimed |
| WO-1996007676-A1 | POLYMERIC RESIN FOR DISULFIDE BOND SYNTHESIS | EKAGEN CORPORATION (US) | 1996-03-14 | — | — | WO | claimed |
| EP-0505413-B1 | BETA-LACTAM DERIVATIVES | ERBA CARLO SPA (IT) | 1994-08-31 | — | — | EP | claimed |
| EP-0505413-A1 | BETA-LACTAM DERIVATIVES. | ERBA FARMITALIA (IT) | 1992-09-30 | — | — | EP | claimed |
| WO-1991009036-A1 | BETA-LACTAM DERIVATIVES | FARMITALIA CARLO ERBA S.R.L. (IT) | 1991-06-27 | — | — | WO | claimed |
| EP-0208776-A1 | CARRIER-BOUND HISTAMINE, ITS MANUFACTURE AND ITS USE | PHARMACIA AB (SE) | 1987-01-21 | — | — | EP | claimed |
| WO-1986004331-A1 | CARRIER-BOUND HISTAMINE, ITS MANUFACTURE AND ITS USE | PHARMACIA AB (SE) | 1986-07-31 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210170037-A1 | BRANCHED SUGAR ALCOHOL-BASED COMPOUNDS, AND COMPOSITIONS AND METHODS THEREOF | SIGLEC7, CD44, SIGLEC9 | DTYMK 602/4885TSHR 2001/4885CASP6 4672/4885 |
| US-20030055226-A1 | Methods for preparation of cytotoxic conjugates of maytansinoids and cell binding agents | SPR, SELPLG, CD2BP2 | DTYMK 565/4885TSHR 2205/4885CASP6 1625/4885 |
| US-20230233697-A1 | CYTOTOXIC BENZODIAZEPINE DERIVATIVES | GABRA6, GABBR1, GABRA5 | DTYMK 3718/4885TSHR 889/4885CASP6 1118/4885 |
| US-20240197898-A1 | SUBSTITUTED BENZO[5,6][1,4]DIAZEPINO[1,2-a]INDOLES FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | MKI67, GABBR1, GABBR2 | DTYMK 2746/4885TSHR 879/4885CASP6 3437/4885 |
| US-20230094471-A1 | CYTOTOXIC BIS-BENZODIAZEPINE DERIVATIVES AND CONJUGATES THEREOF WITH CELL-BINDING AGENTS FOR INHIBITING ABNORMAL CELL GROWTH OR FOR TREATING PROLIFERATIVE DISEASES | GABBR2, GABRB1, GABRB2 | DTYMK 2264/4885TSHR 269/4885CASP6 2091/4885 |
| US-11793885-B2 | Substituted benzo[5,6][1,4]diazepino[1,2-a]indoles for the treatment of proliferative disorders | MKI67, GABBR1, GABBR2 | DTYMK 2746/4885TSHR 879/4885CASP6 3437/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.