Ethylbenzene

Ethylbenzene

SCHEMBL246705

CCc1ccccc1.Cl.N

nearest known ligand 0.88

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Ethylbenzene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
TP53 P04637 1/20 0.88
KDM4E B2RXH2 2/20 0.48
CYP3A4 P08684 2/20 0.48
MAPT P10636 2/20 0.48
CALM1 P0DP23 1/20 0.47
ALDH1A1 P00352 4/20 0.44
CYP1A2 P05177 1/20 0.44
CYP2A6 P11509 1/20 0.44
TSHR P16473 3/20 0.43
IDO1 P14902 1/20 0.43
LOXL2 Q9Y4K0 1/20 0.43
TRPA1 O75762 1/20 0.43
POLB P06746 1/20 0.42
RAB9A P51151 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
TDP1 Q9NUW8 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Ethylbenzene SCHEMBL27791172 0.97 TP53 (0.82) TP53KDM4ECYP3A4MAPTCALM1
Ethylbenzene SCHEMBL57658 0.97
Ethylbenzene SCHEMBL355150 0.97
Ethylbenzene SCHEMBL7547889 0.97 TP53 (0.93) TP53KDM4ECYP3A4MAPTCALM1
Ethylbenzene SCHEMBL11896402 0.97 TP53 (0.93) TP53KDM4ECYP3A4MAPTCALM1
Ethylbenzene SCHEMBL25237466 0.94 TP53 (0.88) TP53KDM4ECYP3A4MAPTCALM1
Ethylbenzene SCHEMBL8197460 0.94 TP53 (0.88) TP53KDM4ECYP3A4MAPTCALM1
Ethylbenzene SCHEMBL9403136 0.94 TP53 (0.88) TP53KDM4ECYP3A4MAPTCALM1
Ethylbenzene SCHEMBL29290394 0.94 TP53 (0.88) TP53KDM4ECYP3A4MAPTCALM1
Ethylbenzene SCHEMBL7271859 0.94 TP53 (0.88) TP53KDM4ECYP3A4MAPTCALM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 47 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-218422082-U A mixer that is used for quaternary ammonium salt benzethonium chloride to strain impurity 南京和创材料科技有限公司 2023-02-03 CN claimed
US-7871649-B2 Antimicrobial compositions containing synergistic combinations of quaternary ammonium compounds and essential oils and/or constituents thereof THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2011-01-18 US claimed
US-4169943-A PROCESS FOR THE PREPARATION OF AMINO DERIVATIVES OF N-HETEROCYCLES SCHERING AKTIENGESELLSCHAFT (DE) 1979-10-02 US claimed
CN-115616100-B Method for simultaneously detecting multiple biogenic amines in food by adopting high performance liquid chromatography 广东珠江桥生物科技股份有限公司 2025-04-29 CN disclosed
CN-220658233-U Screening device for preparing ammonium salt benzethonium chloride 南京和创材料科技有限公司 2024-03-26 CN disclosed
CN-114923993-B Liquid chromatography system based on pre-column online derivatization method and application method 华南理工大学 2023-06-20 CN disclosed
CN-219199859-U A desiccator for ammonium salt benzethonium chloride 南京和创材料科技有限公司 2023-06-16 CN disclosed
CN-218422082-U A mixer that is used for quaternary ammonium salt benzethonium chloride to strain impurity 南京和创材料科技有限公司 2023-02-03 CN disclosed
CN-115149003-A Multi-shell structure alloy catalyst for fuel cell and preparation method and application thereof 东风汽车集团股份有限公司 2022-10-04 CN disclosed
CN-110129306-A Immobilization transaminase and its application 广东东阳光药业有限公司 2019-08-16 CN disclosed
CN-109221681-A A kind of preparation method of cow feed additive 黄拥亮 2019-01-18 CN disclosed
US-5151418-A Muscle relaxants A. H. ROBINS COMPANY, INCORPORATED (US) 1992-09-29 US disclosed
US-5130309-A Cardiovascular disorders A. H. ROBINS COMPANY, INCORPORATED (US) 1992-07-14 US disclosed
US-5068231-A Ureas and thioureas for relaxing muscles A. H. ROBINS COMPANY INCORPORATED (US) 1991-11-26 US disclosed
US-4956359-A CARBOXAMIDES OR THIOCARBOXAMIDES OF ARYL OXY OR THIO AZETIDINES A. H. ROBINS COMPANY, INC. (US) 1990-09-11 US disclosed
US-4780252-A FORMING SALT WITH SINGLE ISOMERS OF OPTICAL ACTIVE AMINE IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1988-10-25 US disclosed
US-4683089-A SEPARATION OF OPTICAL ISOMERS, INSECTICIDES IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) 1987-07-28 US disclosed
EP-0010874-B1 PROCESS FOR SEPARATING OPTICAL ISOMERS OF SUBSTITUTED CYCLOPROPANE CARBOXYLIC ACIDS; AMINE SALTS OF SUBSTITUTED CYCLOPROPANE CARBOXYLIC ACIDS; A SUBSTITUTED CYCLOPROPANE CARBOXYLIC ACID IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1983-06-22 EP disclosed
EP-0010874-A1 Process for separating optical isomers of substituted cyclopropane carboxylic acids; amine salts of substituted cyclopropane carboxylic acids; a substituted cyclopropane carboxylic acid IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1980-05-14 EP disclosed
US-4169943-A PROCESS FOR THE PREPARATION OF AMINO DERIVATIVES OF N-HETEROCYCLES SCHERING AKTIENGESELLSCHAFT (DE) 1979-10-02 US disclosed