Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA2D1 known ✓ | P54289 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.33 |
| ▸ | GRM3 | Q14832 | 2/20 | 0.33 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | GRM8 | O00222 | 1/20 | 0.33 |
| ▸ | GRM6 | O15303 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.33 |
| ▸ | PLCB1 | Q9NQ66 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL2234516 | 1.00 | CYP2C19 (0.44) | CYP2C19LMNACYP1A2TSHRUSP2 | |
| SCHEMBL21694281 | 0.98 | CYP2C19 (0.46) | CYP2C19LMNACYP1A2TSHRUSP2 | |
| Hydrochloric Acid SCHEMBL946949 | 0.85 | CYP2C19 (0.58) | CYP2C19LMNACYP1A2TSHRUSP2 | |
| SCHEMBL16143297 | 0.85 | USP2 (0.33) | CYP2C19LMNACYP1A2TSHRUSP2 | |
| Hydrochloric Acid SCHEMBL20773302 | 0.83 | CYP2C19 (0.54) | CYP2C19LMNACYP1A2TSHRUSP2 | |
| SCHEMBL1526434 | 0.83 | CYP2C19 (0.60) | CYP2C19LMNACYP1A2TSHRUSP2 | |
| SCHEMBL1821191 | 0.81 | CYP2C19 (0.56) | CYP2C19LMNACYP1A2TSHRUSP2 | |
| Hydrochloric Acid SCHEMBL21930733 | 0.79 | CYP2C19 (0.48) | CYP2C19LMNACYP1A2TSHRUSP2 | |
| SCHEMBL15268430 | 0.77 | — | — | |
| Hydrochloric Acid SCHEMBL5665222 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111356434-B | Composition comprising an oil and a polyion complex comprising a cellulose-based cationic polymer having at least one fatty chain | 莱雅公司 | 2023-10-20 | — | — | CN | disclosed |
| CN-116617116-A | Combination of polyion complex particles and non-polymeric acids having two or more acid dissociation constants | 莱雅公司 | 2023-08-22 | — | — | CN | disclosed |
| CN-116437972-A | Oil-in-water emulsion compositions comprising platinum catalysts and methods of use thereof | 株式会社资生堂 | 2023-07-14 | — | — | CN | disclosed |
| CN-111329788-B | Copolymer | 宝丽化学工业有限公司 | 2023-03-31 | — | — | CN | disclosed |
| CN-111329787-B | Copolymer | 宝丽化学工业有限公司 | 2023-03-31 | — | — | CN | disclosed |
| CN-115335032-A | Aqueous composition | 株式会社高丝 | 2022-11-11 | — | — | CN | disclosed |
| CN-115066227-A | Oil-in-water type emulsified cosmetic | 株式会社高丝 | 2022-09-16 | — | — | CN | disclosed |
| CN-114828805-A | Oil-in-water emulsion cosmetic for skin care using electrophoresis | 株式会社资生堂 | 2022-07-29 | — | — | CN | disclosed |
| CN-114599342-A | Water-in-oil type emulsified sunscreen cosmetic | 株式会社资生堂 | 2022-06-07 | — | — | CN | disclosed |
| CN-114502135-A | W/O/W type emulsified composition | 株式会社资生堂 | 2022-05-13 | — | — | CN | disclosed |
| EP-3067038-B1 | SKIN WHITENING AGENT | SHISEIDO CO LTD (JP) | 2017-10-11 | — | — | EP | disclosed |
| EP-3067038-A1 | SKIN WHITENING AGENT | SHISEIDO COMPANY, LTD. (JP) | 2016-09-14 | — | — | EP | disclosed |
| EP-2251000-B1 | SKIN WHITENING AGENT AND EXTERNAL PREPARATION FOR THE SKIN | SHISEIDO CO LTD (JP) | 2016-04-13 | — | — | EP | disclosed |
| US-8367082-B2 | Microgel and external compositions containing the same | SHISEIDO COMPANY, LTD. (JP) | 2013-02-05 | — | — | US | disclosed |
| EP-1158021-B1 | MICROGELS AND EXTERNAL PREPARATIONS CONTAINING THE SAME | SHISEIDO CO LTD (JP) | 2011-10-05 | — | — | EP | disclosed |
| EP-2251001-A1 | SKIN WHITENING AGENT AND EXTERNAL PREPARATION FOR THE SKIN | Shiseido Company, Ltd. (JP) | 2010-11-17 | — | — | EP | disclosed |
| EP-2250999-A1 | SKIN WHITENING AGENT AND EXTERNAL PREPARATION FOR THE SKIN | Shiseido Company, Ltd. (JP) | 2010-11-17 | — | — | EP | disclosed |
| US-20090047312-A1 | Microgel and external compositions containing the same | SHISEIDO CO., LTD. (JP) | 2009-02-19 | — | — | US | disclosed |
| US-20030072805-A1 | Microgel and external compositions containing the same | SHISEIDO COMPANY, LTD. (JP) | 2003-04-17 | — | — | US | disclosed |
| EP-1158021-A1 | MICROGELS AND EXTERNAL PREPARATIONS CONTAINING THE SAME | SHISEIDO COMPANY LIMITED (JP) | 2001-11-28 | — | — | EP | disclosed |