Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 known ✓ | P00918 | 1/20 | 0.42 |
| ▸ | TTR known ✓ | P02766 | 1/20 | 0.40 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | MPL | P40238 | 3/20 | 0.46 |
| ▸ | CTRC | Q99895 | 2/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.41 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.41 |
| ▸ | LDHA | P00338 | 1/20 | 0.40 |
| ▸ | ERN1 | O75460 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL41541 | 0.98 | CYP2D6 (0.53) | CTRB1CYP2D6MPLCTRCCA1 | |
| SCHEMBL3233255 | 0.96 | CYP2D6 (0.51) | CTRB1CYP2D6MPLCTRCCA1 | |
| SCHEMBL8835967 | 0.96 | CYP2D6 (0.51) | CTRB1CYP2D6MPLCTRCCA1 | |
| SCHEMBL4897459 | 0.96 | CYP2D6 (0.51) | CTRB1CYP2D6MPLCTRCCA1 | |
| SCHEMBL4314625 | 0.96 | CYP2D6 (0.51) | CTRB1CYP2D6MPLCTRCCA1 | |
| SCHEMBL5077155 | 0.96 | CYP2D6 (0.51) | CTRB1CYP2D6MPLCTRCCA1 | |
| SCHEMBL3233245 | 0.96 | CYP2D6 (0.51) | CTRB1CYP2D6MPLCTRCCA1 | |
| SCHEMBL4578484 | 0.96 | CYP2D6 (0.51) | CTRB1CYP2D6MPLCTRCCA1 | |
| Water SCHEMBL669870 | 0.96 | CYP2D6 (0.51) | CTRB1CYP2D6MPLCTRCCA1 | |
| SCHEMBL2242476 | 0.96 | CYP2D6 (0.51) | CTRB1CYP2D6MPLCTRCCA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110343279-A | A kind of interfacial polymerization prepares the method and its product and purposes of composite polypropylene microporous barrier | 北京师范大学 | 2019-10-18 | — | — | CN | claimed |
| CN-110343279-A | A kind of interfacial polymerization prepares the method and its product and purposes of composite polypropylene microporous barrier | 北京师范大学 | 2019-10-18 | — | — | CN | disclosed |
| CN-101824775-B | Paper production with modified silica gels as microparticles | KEMIRA OYJ | 2013-11-06 | — | — | CN | disclosed |
| US-8088830-B2 | silica sol containing sulfonic acid groups and/or mercapto groups is added to an aqueous cellulose suspension, and sheet formation, drainage and drying of the sheet are then carried out | KEMIRA OYJ (FI) | 2012-01-03 | — | — | US | disclosed |
| CN-101824775-A | Ludox with modification is made paper as particulate | STARCK H C GMBH | 2010-09-08 | — | — | CN | disclosed |
| CN-1816663-B | Paper making using modified silica sols as particles | KEMIRA OYJ | 2010-06-16 | — | — | CN | disclosed |
| US-20100108277-A1 | PAPER PRODUCTION WITH MODIFIED SILICA GELS AS MICROPARTICLES | KEMIRA OYJ (FI) | 2010-05-06 | — | — | US | disclosed |
| US-7708862-B2 | Paper production with modified silica gels as microparticles | KEMIRA OYJ (FI) | 2010-05-04 | — | — | US | disclosed |
| CN-100354318-C | Aromatic polymer, its prodn, process and application | SUMITOMO CHEMICAL CO (JP) | 2007-12-12 | — | — | CN | disclosed |
| US-20070272383-A1 | Paper Production with Modified Silica Sols as Microparticles | BAYER CHEMICALS AG (DE) | 2007-11-29 | — | — | US | disclosed |
| CN-100342572-C | Polymer laminated film, method for producing same, and use thereof | SUMITOMO CHEMICAL CO (JP) | 2007-10-10 | — | — | CN | disclosed |
| CN-1816663-A | Paper making using modified silica sols as particles | LANXESS DEUTSCHLAND GMBH (DE) | 2006-08-09 | — | — | CN | disclosed |
| CN-1671806-A | Ink | AVECIA LTD (GB) | 2005-09-21 | — | — | CN | disclosed |
| CN-1666369-A | Polymer laminated film, method for producing same, and use thereof | SUMITOMO CHEMICAL CO (JP) | 2005-09-07 | — | — | CN | disclosed |
| CN-1446828-A | Aromatic polymer, its prodn, process and application | SUMITOMO CHEMICAL CO (JP) | 2003-10-08 | — | — | CN | disclosed |
| CN-1295677-A | Method and apparatus for accelerated orthokeratology | EASTA PHARMACEUTICALS INC (US) | 2001-05-16 | — | — | CN | disclosed |
| US-4434104-A | REACTING NAPHTHALENEDISULFONATE CHLORIDE AND EXCESS ALCOHOL, TREATING WITH ALKALI METAL ALCOHOLATE AND WASHING | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 1984-02-28 | — | — | US | disclosed |
| US-4060549-A | Process for preparing sulfonic acid fluorides | BAYER AKTIENGESELLSCHAFT (DT) | 1977-11-29 | — | — | US | disclosed |