Hydrochloric Acid

Hydrochloric Acid

SCHEMBL25235124

CNC(=O)c1ccc(N2CCNCC2)c(F)n1.Cl

nearest known ligand 0.50

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
PARP1 known ✓ P09874 16/20 0.50
KCNH2 known ✓ Q12809 2/20 0.47
HTR6 known ✓ P50406 1/20 0.39
PARP2 Q9UGN5 12/20 0.50
PARP6 Q2NL67 5/20 0.48
PARP3 Q9Y6F1 4/20 0.48
TNKS O95271 3/20 0.48
BACE1 P56817 1/20 0.43
USP28 Q96RU2 1/20 0.39
USP25 Q9UHP3 1/20 0.39
CHEK1 O14757 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL29394088 1.00 PARP1 (0.50) PARP1PARP2PARP6PARP3TNKS
Hydrochloric Acid SCHEMBL30413981 1.00 PARP1 (0.50) PARP1PARP2PARP6PARP3TNKS
SCHEMBL22912765 0.99 PARP1 (0.51) PARP1PARP2PARP6PARP3TNKS
Hydrochloric Acid SCHEMBL30218620 0.91 PARP1 (0.43) PARP1PARP2PARP6PARP3TNKS
Hydrochloric Acid SCHEMBL31159549 0.91 PARP1 (0.43) PARP1PARP2PARP6PARP3TNKS
SCHEMBL30218632 0.90 PARP1 (0.44) PARP1PARP2PARP6PARP3TNKS
Hydrochloric Acid SCHEMBL31049743 0.86 PARP1 (0.49) PARP1PARP2PARP6PARP3TNKS
Hydrochloric Acid SCHEMBL31271826 0.86 PARP1 (0.43) PARP1PARP2PARP6PARP3TNKS
Hydrochloric Acid SCHEMBL25236649 0.85 PARP1 (0.48) PARP1PARP2PARP6PARP3TNKS
Hydrochloric Acid SCHEMBL30413282 0.85 PARP1 (0.48) PARP1PARP2PARP6PARP3TNKS

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116348115-B Combination of antibody-drug conjugate and PARP1 selective inhibitor ASTRAZENECA UK LTD. (GB) 2026-05-26 CN disclosed
US-20260098024-A1 PARP1 INHIBITORS AND USES THEREOF XINTHERA INC (US) 2026-04-09 US disclosed
EP-4620472-A2 TRICYCLIC PARP1 INHIBITORS AND USES THEREOF Xinthera, Inc. (US) 2025-09-24 EP disclosed
US-12421241-B2 Substituted pyridines as PARP1 inhibitors XINTHERA, INC. (US) 2025-09-23 US disclosed
EP-4497438-B1 TRICYCLIC PARP1 INHIBITORS AND USES THEREOF XINTHERA INC (US) 2025-09-03 EP disclosed
EP-4355749-B1 TRICYCLIC PARP1 INHIBITORS AND USES THEREOF XINTHERA INC (US) 2025-06-04 EP disclosed
US-20250163022-A1 PARP1 INHIBITORS SYNNOVATION THERAPEUTICS, INC. 2025-05-22 US disclosed
WO-2025036290-A1 FUSED TRICYCLIC COMPOUND, PHARMACEUTICAL COMPOSITION THEREOF, AND USE THEREOF 上海海和药物研究开发股份有限公司 2025-02-20 WO disclosed
EP-4497438-A2 TRICYCLIC PARP1 INHIBITORS AND USES THEREOF Xinthera, Inc. (US) 2025-01-29 EP disclosed
US-20240400569-A1 SUBSTITUTED PYRIDINES AS PARP1 INHIBITORS XINTHERA, INC. 2024-12-05 US disclosed
EP-4355749-A1 TRICYCLIC PARP1 INHIBITORS AND USES THEREOF Xinthera, Inc. (US) 2024-04-24 EP disclosed
US-20240109904-A1 SUBSTITUTED PYRIDINES AS PARP1 INHIBITORS XINTHERA, INC. 2024-04-04 US disclosed
WO-2024050370-A1 HETEROCYCLIC COMPOUNDS AND METHODS OF USE THEREOF 1CBIO, INC. (US) 2024-03-07 WO disclosed
US-20230348473-A1 SUBSTITUTED PYRIDINES AS PARP1 INHIBITORS XINTHERA, INC. 2023-11-02 US disclosed
WO-2023212219-A1 TRICYCLIC PARP1 INHIBITORS AND USES THEREOF XINTHERA, INC. (US) 2023-11-02 WO disclosed
US-11795173-B1 Substituted pyridines as PARP1 inhibitors XINTHERA, INC. (US) 2023-10-24 US disclosed
WO-2023146957-A1 PARP1 INHIBITORS AND USES THEREOF XINTHERA, INC. (US) 2023-08-03 WO disclosed
WO-2023122140-A1 PARP1 INHIBITORS SYNNOVATION THERAPEUTICS, INC. (US) 2023-06-29 WO disclosed
CN-116348115-A Combination of antibody-drug conjugate and PARP1 selective inhibitor 阿斯利康(英国)有限公司 2023-06-27 CN disclosed
CN-114144413-A PARP1 inhibitors 阿斯利康(瑞典)有限公司 2022-03-04 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230348473-A1 SUBSTITUTED PYRIDINES AS PARP1 INHIBITORS PARP1, PARP11, PARP12 PARP1 1/4885KCNH2 4492/4885HTR6 1762/4885
US-12421241-B2 Substituted pyridines as PARP1 inhibitors PARP1, PARP11, PARP12 PARP1 1/4885KCNH2 4492/4885HTR6 1762/4885
US-20250163022-A1 PARP1 INHIBITORS PARP1, PARP11, PARP12 PARP1 1/4885KCNH2 4620/4885HTR6 2222/4885
US-20240109904-A1 SUBSTITUTED PYRIDINES AS PARP1 INHIBITORS PARP1, PARP11, PARP12 PARP1 1/4885KCNH2 4492/4885HTR6 1762/4885
US-20260098024-A1 PARP1 INHIBITORS AND USES THEREOF PARP1, PARP11, PARP16 PARP1 1/4885KCNH2 2346/4885HTR6 186/4885
US-20240400569-A1 SUBSTITUTED PYRIDINES AS PARP1 INHIBITORS PARP1, PARP11, PARP12 PARP1 1/4885KCNH2 4492/4885HTR6 1762/4885
US-11795173-B1 Substituted pyridines as PARP1 inhibitors PARP1, PARP11, PARP12 PARP1 1/4885KCNH2 4382/4885HTR6 2073/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.