Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | APEX1 | P27695 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | BHMT | Q93088 | 2/20 | 0.33 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.32 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.32 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14455151 | 0.85 | LMNA (0.60) | LMNAGAASMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL28919595 | 0.85 | LMNA (0.60) | LMNAGAASMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL18862772 | 0.82 | LMNA (0.47) | LMNAGAAKDM4ESMN1; SMN2MAPT | |
| SCHEMBL806271 | 0.78 | — | — | |
| SCHEMBL12417193 | 0.77 | LMNA (0.50) | LMNAGAAKDM4ESMN1; SMN2MAPT | |
| SCHEMBL12107301 | 0.77 | CES2 (0.42) | LMNAKDM4ESMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL8458271 | 0.76 | GPR84 (0.50) | LMNAGAAKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL20651364 | 0.76 | GPR84 (0.50) | LMNAGAAKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL17258247 | 0.76 | GPR84 (0.50) | LMNAGAAKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL21341927 | 0.76 | GPR84 (0.50) | LMNAGAAKDM4ESMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9714419-B2 | PEGylated tyrosyl-tRNA synthetase polypeptides | ATYR PHARMA, INC. (US) | 2017-07-25 | — | — | US | disclosed |
| US-9682153-B2 | Polymer conjugates of therapeutic peptides | NEKTAR THERAPEUTICS (US) | 2017-06-20 | — | — | US | disclosed |
| US-9433684-B2 | Conjugates of small-interfering nucleic acids | NEKTAR THERAPEUTICS (US) | 2016-09-06 | — | — | US | disclosed |
| US-9421275-B2 | Oligomer-calcimimetic conjugates and related compunds | NEKTAR THERAPEUTICS (US) | 2016-08-23 | — | — | US | disclosed |
| US-9347054-B2 | Polymer factor IX moiety conjugates | NEKTAR THERAPEUTICS (US) | 2016-05-24 | — | — | US | disclosed |
| US-20160022828-A1 | POLYMER CONJUGATES OF THERAPEUTIC PEPTIDES | NEKTAR THERAPEUTICS | 2016-01-28 | — | — | US | disclosed |
| US-20150159148-A1 | PEGYLATED ASPARTYL-TRNA SYNTHETASE POLYPEPTIDES | ATYR PHARMA, INC. | 2015-06-11 | — | — | US | disclosed |
| US-20140328791-A1 | Conjugates of an IL-2 Moiety and a Polymer | NEKTAR THERAPEUTICS | 2014-11-06 | — | — | US | disclosed |
| US-20140323565-A1 | Oligomer-Calcimimetic Conjugates and Related Compunds | NEKTAR THERAPEUTICS (US) | 2014-10-30 | — | — | US | disclosed |
| US-20140255378-A1 | PEGYLATED TYROSYL-TRNA SYNTHETASE POLYPEPTIDES | ATYR PHARMA, INC (US) | 2014-09-11 | — | — | US | disclosed |
| US-20120100096-A1 | CONJUGATES PF SMALL-INTERFERING NUCLEIC ACIDS | NEKTAR THERAPEUTICS (US) | 2012-04-26 | — | — | US | disclosed |
| US-20110318322-A1 | Conjugates of a Lysosomal Enzyme Moiety and a Water Soluble Polymer | NEKTAR THERAPEUTICS (US) | 2011-12-29 | — | — | US | disclosed |
| US-20110206633-A1 | POLYMER CONJUGATES OF CD-NP PEPTIDES | Nektar Therapectics (US) | 2011-08-25 | — | — | US | disclosed |
| US-20110171165-A1 | POLYMER CONJUGATES OF OPIOID GROWTH FACTOR PEPTIDES | NEKTAR THERAPEUTICS | 2011-07-14 | — | — | US | disclosed |
| US-20110171160-A1 | POLYMER CONJUGATES OF KISS1 PEPTIDES | NEKTAR THERAPEUTICS (US) | 2011-07-14 | — | — | US | disclosed |
| US-20110171164-A1 | POLYMER CONJUGATES OF GLP-2-LIKE PEPTIDES | NEKTAR THERAPEUTICS (US) | 2011-07-14 | — | — | US | disclosed |
| US-20110171312-A1 | MODIFIED THERAPEUTIC PEPTIDES, METHODS OF THEIR PREPARATION AND USE | NEKTAR THERAPEUTICS (US) | 2011-07-14 | — | — | US | disclosed |
| US-20110165112-A1 | POLYMER CONJUGATES OF C-PEPTIDES | NEKTAR THERAPEUTICS (US) | 2011-07-07 | — | — | US | disclosed |
| US-20110166063-A1 | POLYMER CONJUGATES OF THERAPEUTIC PEPTIDES | NEKTAR THERAPEUTICS (US) | 2011-07-07 | — | — | US | disclosed |
| US-20110135623-A1 | Conjugates of a Cholinesterase Moiety and a Polymer | NEKTAR THERAPEUTICS (US) | 2011-06-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (14 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150159148-A1 | PEGYLATED ASPARTYL-TRNA SYNTHETASE POLYPEPTIDES | AARS1, GARS1, DARS1 | LMNA 3388/4885GAA 198/4885KDM4E 4368/4885 |
| US-20110171160-A1 | POLYMER CONJUGATES OF KISS1 PEPTIDES | KISS1R, PROKR1, NGLY1 | LMNA 4316/4885GAA 2182/4885KDM4E 3236/4885 |
| US-20140328791-A1 | Conjugates of an IL-2 Moiety and a Polymer | IL2, IL2RA, ILF2 | LMNA 3299/4885GAA 1870/4885KDM4E 4451/4885 |
| US-20110135623-A1 | Conjugates of a Cholinesterase Moiety and a Polymer | BCHE, ACHE, DNPEP | LMNA 2903/4885GAA 22/4885KDM4E 2231/4885 |
| US-20110206633-A1 | POLYMER CONJUGATES OF CD-NP PEPTIDES | CD63, CLSPN, LNPEP | LMNA 2734/4885GAA 872/4885KDM4E 4872/4885 |
| US-20160022828-A1 | POLYMER CONJUGATES OF THERAPEUTIC PEPTIDES | NGLY1, CD44, IAPP | LMNA 4498/4885GAA 710/4885KDM4E 4758/4885 |
| US-20110165112-A1 | POLYMER CONJUGATES OF C-PEPTIDES | IAPP, GCG, INSR | LMNA 1369/4885GAA 1843/4885KDM4E 4796/4885 |
| US-20110166063-A1 | POLYMER CONJUGATES OF THERAPEUTIC PEPTIDES | NGLY1, CD44, IAPP | LMNA 4498/4885GAA 710/4885KDM4E 4758/4885 |
| US-20110171312-A1 | MODIFIED THERAPEUTIC PEPTIDES, METHODS OF THEIR PREPARATION AND USE | DNPEP, VIP, PTMS | LMNA 2283/4885GAA 1455/4885KDM4E 4718/4885 |
| US-20110171165-A1 | POLYMER CONJUGATES OF OPIOID GROWTH FACTOR PEPTIDES | OGFR, OGFRL1, OPRL1 | LMNA 4797/4885GAA 2443/4885KDM4E 4007/4885 |
| US-20120100096-A1 | CONJUGATES PF SMALL-INTERFERING NUCLEIC ACIDS | SLC19A1, FOLR1, SLC46A1 | LMNA 1117/4885GAA 639/4885KDM4E 4594/4885 |
| US-20110171164-A1 | POLYMER CONJUGATES OF GLP-2-LIKE PEPTIDES | IAPP, GLP1R, GIPR | LMNA 4143/4885GAA 1688/4885KDM4E 3559/4885 |
| US-20110318322-A1 | Conjugates of a Lysosomal Enzyme Moiety and a Water Soluble Polymer | GAA, MAN2B1, GBA1 | LMNA 881/4885GAA 1/4885KDM4E 3664/4885 |
| US-20140323565-A1 | Oligomer-Calcimimetic Conjugates and Related Compunds | CALCR, CALCB, CALCA | LMNA 3957/4885GAA 1392/4885KDM4E 4843/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.