Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA known ✓ | P10253 | 1/20 | 0.41 |
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.38 |
| ▸ | CHRM4 known ✓ | P08173 | 1/20 | 0.38 |
| ▸ | CHRM5 known ✓ | P08912 | 1/20 | 0.38 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.38 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 4/20 | 0.55 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | APEX1 | P27695 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1254834 | 0.98 | TSHR (0.56) | TSHRTHRBPOLBAPEX1HTT | |
| SCHEMBL112006 | 0.96 | TSHR (0.58) | TSHRTHRBPOLBAPEX1HTT | |
| Hydrochloric Acid SCHEMBL28118669 | 0.95 | TSHR (0.58) | TSHRTHRBPOLBAPEX1HTT | |
| Iodide SCHEMBL1252765 | 0.94 | TSHR (0.56) | TSHRTHRBPOLBAPEX1HTT | |
| Bromide SCHEMBL1254033 | 0.94 | TSHR (0.56) | TSHRTHRBPOLBAPEX1HTT | |
| Fluoride SCHEMBL1254048 | 0.94 | TSHR (0.56) | TSHRTHRBPOLBAPEX1HTT | |
| Hydrochloric Acid SCHEMBL1254853 | 0.93 | TSHR (0.59) | TSHRTHRBPOLBAPEX1HTT | |
| Acetic Acid SCHEMBL21544994 | 0.93 | TSHR (0.55) | TSHRTHRBPOLBAPEX1HTT | |
| Chloromethane SCHEMBL28424215 | 0.93 | TSHR (0.55) | TSHRTHRBPOLBAPEX1HTT | |
| Methacrylic Acid SCHEMBL1719703 | 0.91 | TSHR (0.53) | TSHRTHRBPOLBAPEX1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105745188-B | High efficiency rheology modifiers with cationic components and uses thereof | 赫尔克里士公司 | 2019-09-10 | — | — | CN | claimed |
| CN-104098746-B | Adamantyl contained hydrophobic association zwitter-ion starch and preparation method thereof | 西南石油大学 | 2017-01-25 | — | — | CN | claimed |
| CN-106046248-A | Cationic flocculant and preparation method thereof | 四川科尔瑞环保科技有限责任公司 | 2016-10-26 | — | — | CN | claimed |
| CN-110200827-A | Double coating processes of dyeing keratin fibres | 莱雅公司 | 2019-09-06 | — | — | CN | disclosed |
| CN-109908028-A | Cosmetic composition, colouring method and device | 莱雅公司 | 2019-06-21 | — | — | CN | disclosed |
| CN-109790404-A | Novel RAFT polymerize anti-soil technology | 佛罗里达大学研究基金会公司 | 2019-05-21 | — | — | CN | disclosed |
| CN-109476861-A | The thermal induction of non-woven fabric for high capacity ionic energy transfer is grafted | 北卡罗莱纳州立大学 | 2019-03-15 | — | — | CN | disclosed |
| CN-109456450-A | A method of based on spin-coating method and being cross-linked in situ polymerization preparation double-layer composite antibacterial bacteriostatic medical films | 四川大学 | 2019-03-12 | — | — | CN | disclosed |
| CN-104066419-B | Method for treating straightened keratin fibers | 莱雅公司 | 2018-05-08 | — | — | CN | disclosed |
| CN-107750154-A | Composition for dyeing hair using cationic direct dyes | 诺赛尔股份有限公司 | 2018-03-02 | — | — | CN | disclosed |
| CN-107635536-A | Method for dyeing hair using direct dye compounds | 诺赛尔股份有限公司 | 2018-01-26 | — | — | CN | disclosed |
| CN-102574961-B | Hybrid copolymer composition | Akzo Nobel Co.,Ltd. (NL) | 2015-09-23 | — | — | CN | disclosed |
| CN-103154093-B | Sugar silicone copolymers and preparation and application thereof | DOW CORNING CORP. (US) | 2015-08-26 | — | — | CN | disclosed |
| CN-104739669-A | COMPOSITION COMPRISING AT LEAST ONE FATTY SUBSTANCE AND AT LEAST ONE CATIONIC POLYMER, DYEING OR LIGHTENING PROCESS USING IT AND DEVICES THEREFOR | OREAL | 2015-07-01 | — | — | CN | disclosed |
| CN-104684533-A | Agent for changing the colour of keratin fibres, comprising an aliphatic substance and a rheology-modifying polymer in an emulsion system | OREAL | 2015-06-03 | — | — | CN | disclosed |
| CN-103319940-B | Inkjet recording ink, ink cartridge, and inkjet recording method | RICOH CO LTD | 2015-03-25 | — | — | CN | disclosed |
| CN-104427967-A | Method for forming a coloured pattern on keratin fibres using a composition comprising a hydrophobic film-forming polymer, at least one volatile solvent and at least one pigment | OREAL | 2015-03-18 | — | — | CN | disclosed |
| CN-104379115-A | Double-coating method for dyeing keratin fibers | OREAL | 2015-02-25 | — | — | CN | disclosed |
| CN-102858314-B | Cosmetic composition based on ellagic acid or a derivative thereof and a bacterial extract | OREAL | 2015-01-28 | — | — | CN | disclosed |
| CN-101076395-A | Encapsulation product, process for producing the same, and ink composition | SEIKO EPSON CORP (JP) | 2007-11-21 | — | — | CN | disclosed |