Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 known ✓ | P00918 | 13/20 | 0.94 |
| ▸ | HSP90AA1 known ✓ | P07900 | 2/20 | 0.48 |
| ▸ | HSP90AB1 known ✓ | P08238 | 2/20 | 0.48 |
| ▸ | MAOA known ✓ | P21397 | 1/20 | 0.46 |
| ▸ | MAOB known ✓ | P27338 | 1/20 | 0.46 |
| ▸ | ABL1 known ✓ | P00519 | 1/20 | 0.45 |
| ▸ | GAA known ✓ | P10253 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 13/20 | 0.94 |
| ▸ | CA7 | P43166 | 13/20 | 0.94 |
| ▸ | CA9 | Q16790 | 13/20 | 0.94 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.94 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.94 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.94 |
| ▸ | RECQL | P46063 | 2/20 | 0.94 |
| ▸ | EHMT2 | Q96KQ7 | 2/20 | 0.94 |
| ▸ | TSHR | P16473 | 1/20 | 0.94 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.94 |
| ▸ | CASP1 | P29466 | 1/20 | 0.94 |
| ▸ | BACE1 | P56817 | 1/20 | 0.94 |
| ▸ | CA4 | P22748 | 3/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29350272 | 0.97 | CA1 (1.00) | CA1CA2CA7CA9ALDH1A1 | |
| SCHEMBL3658029 | 0.97 | CA1 (1.00) | CA1CA2CA7CA9ALDH1A1 | |
| SCHEMBL17986 | 0.97 | CA1 (1.00) | CA1CA2CA7CA9ALDH1A1 | |
| SCHEMBL29080606 | 0.94 | CA1 (0.94) | CA1CA2CA7CA9ALDH1A1 | |
| SCHEMBL3938478 | 0.94 | CA1 (0.94) | CA1CA2CA7CA9ALDH1A1 | |
| Ammonia Solution, Strong SCHEMBL1286269 | 0.94 | CA1 (0.94) | CA1CA2CA7CA9ALDH1A1 | |
| SCHEMBL4930794 | 0.94 | CA1 (0.94) | CA1CA2CA7CA9ALDH1A1 | |
| SCHEMBL4921601 | 0.94 | CA1 (0.94) | CA1CA2CA7CA9ALDH1A1 | |
| Water SCHEMBL592691 | 0.94 | CA1 (0.94) | CA1CA2CA7CA9ALDH1A1 | |
| Methyl Alcohol SCHEMBL3930226 | 0.92 | CA1 (0.90) | CA1CA2CA7CA9ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113201539-B | Polynucleotides having promoter activity and use thereof for producing target compounds | 中国科学院天津工业生物技术研究所 | 2022-09-06 | — | — | CN | disclosed |
| CN-114874958-A | Strain for producing L-proline and construction method and application thereof | 中国科学院天津工业生物技术研究所 | 2022-08-09 | — | — | CN | disclosed |
| CN-114763372-A | Protein with L-proline efflux function and application thereof | 中国科学院天津工业生物技术研究所 | 2022-07-19 | — | — | CN | disclosed |
| CN-114107141-B | Corynebacterium glutamicum capable of producing L-proline in high yield and method for producing L-proline in high yield | 中国科学院天津工业生物技术研究所 | 2022-07-12 | — | — | CN | disclosed |
| CN-114107141-A | Corynebacterium glutamicum capable of producing L-proline in high yield and method for producing L-proline in high yield | 中国科学院天津工业生物技术研究所 | 2022-03-01 | — | — | CN | disclosed |
| CN-113201539-A | Polynucleotides having promoter activity and use thereof for producing target compounds | 中国科学院天津工业生物技术研究所 | 2021-08-03 | — | — | CN | disclosed |
| CN-112111469-B | Gamma-glutamyl kinase mutant and application thereof | 中国科学院天津工业生物技术研究所 | 2021-02-26 | — | — | CN | disclosed |
| CN-112111469-A | Gamma-glutamyl kinase mutant and application thereof | 中国科学院天津工业生物技术研究所 | 2020-12-22 | — | — | CN | disclosed |