Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Ornithine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2D known ✓ | O15399 | 1/20 | 0.52 |
| ▸ | GRIN3B known ✓ | O60391 | 1/20 | 0.52 |
| ▸ | GRIN1 known ✓ | Q05586 | 1/20 | 0.52 |
| ▸ | GRIN2A known ✓ | Q12879 | 1/20 | 0.52 |
| ▸ | GRIN2B known ✓ | Q13224 | 1/20 | 0.52 |
| ▸ | GRIN2C known ✓ | Q14957 | 1/20 | 0.52 |
| ▸ | GRIN3A known ✓ | Q8TCU5 | 1/20 | 0.52 |
| ▸ | GLA known ✓ | P06280 | 1/20 | 0.52 |
| ▸ | GSR | P00390 | 2/20 | 0.82 |
| ▸ | ARG2 | P78540 | 4/20 | 0.57 |
| ▸ | ARG1 | P05089 | 3/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.52 |
| ▸ | GRM8 | O00222 | 1/20 | 0.52 |
| ▸ | GRM6 | O15303 | 1/20 | 0.52 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.52 |
| ▸ | GRM5 | P41594 | 1/20 | 0.52 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.52 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.52 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.52 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ornithine Aketoglutarate SCHEMBL534810 | 1.00 | GSR (0.82) | GSRARG2ARG1CYP1A2GRM8 | |
| Ornithine Aketoglutarate SCHEMBL28741424 | 1.00 | GSR (0.82) | GSRARG2ARG1CYP1A2GRM8 | |
| Ornithine Aketoglutarate SCHEMBL4813602 | 1.00 | GSR (0.82) | GSRARG2ARG1CYP1A2GRM8 | |
| Ornithine SCHEMBL4813611 | 1.00 | GSR (0.82) | GSRARG2ARG1CYP1A2GRM8 | |
| Ornithine Aketoglutarate SCHEMBL28849602 | 1.00 | GSR (0.82) | GSRARG2ARG1CYP1A2GRM8 | |
| D-Ornithine SCHEMBL8046629 | 1.00 | GSR (0.82) | GSRARG2ARG1CYP1A2GRM8 | |
| Ornithine SCHEMBL15016118 | 1.00 | GSR (0.82) | GSRARG2ARG1CYP1A2GRM8 | |
| D-Ornithine SCHEMBL4813616 | 1.00 | GSR (0.82) | GSRARG2ARG1CYP1A2GRM8 | |
| D-Ornithine SCHEMBL377431 | 1.00 | GSR (0.82) | GSRARG2ARG1CYP1A2GRM8 | |
| Ornithine SCHEMBL18338950 | 1.00 | GSR (0.82) | GSRARG2ARG1CYP1A2GRM8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 2055 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122056386-A | Moisture absorption resistant slow release microcapsule powder and preparation method and application thereof | 大连医诺生物股份有限公司 | 2026-05-19 | — | — | CN | claimed |
| CN-122030612-A | Shear-resistant slow-release microcapsule powder and preparation method and application thereof | 大连医诺生物股份有限公司 | 2026-05-15 | — | — | CN | claimed |
| CN-122012539-A | Fatty acid beta-oxidation pathway coding gene from aspergillus nidulans and application thereof | 浙江工业大学 | 2026-05-12 | — | — | CN | claimed |
| US-20260021185-A1 | LOCAL ANESTHETIC SOLUTION FOR DENTAL AND/OR CONTRAST MEDIA USE | NEOCAINE LLC (US) | 2026-01-22 | — | — | US | claimed |
| US-12516015-B2 | L-ornithine phenyl acetate and methods of making thereof | AMALIVE LIMITED (GB) | 2026-01-06 | — | — | US | claimed |
| US-20250361479-A1 | CELL CULTURE MEDIUM | REGENERON PHARMACEUTICALS, INC. (US) | 2025-11-27 | — | — | US | claimed |
| US-12453693-B2 | Encapsulated fragrance compounds based on natural amino acids | SYMRISE AG (DE) | 2025-10-28 | — | — | US | claimed |
| US-12440432-B2 | Methods and compositions for treatment of skin | TOPIX PHARMACEUTICALS, INC. (US) | 2025-10-14 | — | — | US | claimed |
| CN-120157589-A | Method for preparing ornithine hydrochloride by separating arginine mother liquor | 东晓生物科技股份有限公司 | 2025-06-17 | — | — | CN | claimed |
| EP-4552650-A2 | METHODS AND COMPOSITIONS FOR TREATMENT OF SKIN | Topix Pharmaceuticals, Inc. (US) | 2025-05-14 | — | — | EP | claimed |
| WO-1996016016-A1 | NOVEL (+)-(S)-2-(3-BENZOYLPHENYL)PROPIONIC ACID DERIVATIVES WITH ANALGESIC ACTION AND THE PROCESS FOR THE PREPARATION THEREOF | LABORATORIOS MENARINI S.A. (ES) | 1996-05-30 | — | — | WO | claimed |
| EP-0667246-A1 | Recording sheets containing amino acids, hydroxy acids, and polycarboxyl compounds | XEROX CORPORATION (US) | 1995-08-16 | — | — | EP | claimed |
| EP-0624088-A1 | AMINO ACIDS USEFUL AS INHIBITORS OF THE ADVANCED GLYCOSYLATION OF PROTEINS | THE ROCKEFELLER UNIVERSITY (US) | 1994-11-17 | — | — | EP | claimed |
| US-5334617-A | Preventing food spoilage and animal protein aging | THE ROCKEFELLER UNIVERSITY (US) | 1994-08-02 | — | — | US | claimed |
| WO-1993014750-A2 | AMINO ACIDS USEFUL AS INHIBITORS OF THE ADVANCED GLYCOSYLATION OF PROTEINS | THE ROCKEFELLER UNIVERSITY (US) | 1993-08-05 | — | — | WO | claimed |
| EP-0502007-A4 | METHOD FOR REDUCING BLOOD CHOLESTEROL USING ARGININE | — | 1992-11-19 | — | — | EP | claimed |
| US-5157022-A | Administering arginine nicotinate and di- and tripeptides of arginine | BARBUL ADRIAN (US) | 1992-10-20 | — | — | US | claimed |
| EP-0502007-A1 | ARGININE NICOTINATE FOR REDUCING BLOOD CHOLESTEROL | BARBUL, Adrian (US) | 1992-09-09 | — | — | EP | claimed |
| WO-1991007188-A1 | METHOD FOR REDUCING BLOOD CHOLESTEROL USING ARGININE | BARBUL ADRIAN (US) | 1991-05-30 | — | — | WO | claimed |
| US-4596825-A | Administering alanine and ornithine or derivatives | AJINOMOTO CO., INC. (JP) | 1986-06-24 | — | — | US | claimed |