Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6922205 | 1.00 | — | — | |
| Hydrochloric Acid SCHEMBL27551017 | 0.97 | — | — | |
| SCHEMBL14691463 | 0.97 | — | — | |
| SCHEMBL27948428 | 0.95 | — | — | |
| SCHEMBL28346441 | 0.95 | — | — | |
| Fluoride SCHEMBL27301027 | 0.95 | — | — | |
| SCHEMBL28252220 | 0.95 | — | — | |
| SCHEMBL28767768 | 0.95 | — | — | |
| SCHEMBL11707384 | 0.95 | — | — | |
| Bromide SCHEMBL6828982 | 0.95 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114981260-A | Sigma-1 receptor ligands and uses thereof | 斯特拉斯堡大学 | 2022-08-30 | — | — | CN | claimed |
| CN-102206202-B | Pyridazinone derivative and synthetic method thereof | UNIV HEBEI MEDICAL | 2013-04-17 | — | — | CN | claimed |
| CN-102206202-A | Pyridazinone derivative and synthetic method thereof | UNIV HEBEI MEDICAL | 2011-10-05 | — | — | CN | claimed |
| CN-115872976-B | Quinoline derivative, pharmaceutical composition containing quinoline derivative and application of pharmaceutical composition | 中国药科大学 | 2024-05-14 | — | — | CN | disclosed |
| CN-115872976-A | Quinoline derivative, pharmaceutical composition containing quinoline derivative and application of quinoline derivative | 中国药科大学 | 2023-03-31 | — | — | CN | disclosed |
| EP-4077310-A1 | SIGMA-1 RECEPTOR LIGANDS AND USES THEREOF | Université de Strasbourg (FR) | 2022-10-26 | — | — | EP | disclosed |
| CN-114981260-A | Sigma-1 receptor ligands and uses thereof | 斯特拉斯堡大学 | 2022-08-30 | — | — | CN | disclosed |
| WO-2014159776-A1 | SOLID STATE FORMS OF 6-[4-[3-(R)-2-METHYLPYRROLIDINE-1-YL)-PROPOXY]PHENYL]2H-PYRIDAZINE-3-ONE HYDROCHLORIDE | CEPHALON, INC. (US) | 2014-10-02 | — | — | WO | disclosed |
| CN-101501028-B | 2- (heterocyclylbenzyl) pyridazinone derivatives | MERCK PATENT GMBH | 2013-09-11 | — | — | CN | disclosed |
| US-7790905-B2 | Pharmaceutical propylene glycol solvate compositions | MCNEIL-PPC, INC. (US) | 2010-09-07 | — | — | US | disclosed |
| EP-2124913-A1 | 1-AMINOMETHYL- L- PHENYL- CYCLOHEXANE DERIVATIVES AS DDP-IV INHIBITORS | Novartis AG (CH) | 2009-12-02 | — | — | EP | disclosed |
| CN-1114408-C | Oral medicinal composition containing pyridazinone compound | NISSAN CHEMICAL IND LTD (JP) | 2003-07-16 | — | — | CN | disclosed |
| CN-1323297-A | Pyridazinone derivatives | NIHON NOHYAKU CO LTD (JP) | 2001-11-21 | — | — | CN | disclosed |
| US-6310065-B1 | 3/2-HYDROCHLORIDE OF 4-CHLORO-5-(3-(4-BENZYLPIPERAZIN-1-YL)CARBONYLMETHOXY-4-METHOXYBENZYLAMINO) -3(2H)-PYRIDAZINONE; LESS HYGROSCOPIC AND BETTER STABILITY THAN THE 2-HYDROCHLORIDE | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2001-10-30 | — | — | US | disclosed |
| CN-1293661-A | Pyridazinone hydrochloride compound and process for producing the same | NISSAN CHEMICAL IND LTD (JP) | 2001-05-02 | — | — | CN | disclosed |
| CN-1293661-A | Pyridazinone hydrochloride compound and process for producing the same | NISSAN CHEMICAL IND LTD (JP) | 2001-05-02 | — | — | CN | disclosed |
| US-5942249-A | IMPROVED DISSOLUTION AND ABSORPTION OF ANTIPLATELET AGENTS, HEART STIMULANTS, VASODILATOR, ANTAGONISTS, THROMBOXANE SYNTHETASE INHIBITOR | THE GREEN CROSS CORPORATION (JP) | 1999-08-24 | — | — | US | disclosed |
| CN-1219934-A | Novel pyridazine compounds | ASTRA PHARMA PROD (GB) | 1999-06-16 | — | — | CN | disclosed |
| CN-1194139-A | Oral medicinal composition containing pyridazinone compound | GREEN CROSS CORP (JP) | 1998-09-30 | — | — | CN | disclosed |
| EP-0860169-A2 | Compositions for oral administration containing pyridazinone compounds | THE GREEN CROSS CORPORATION (JP) | 1998-08-26 | — | — | EP | disclosed |