Water

Water

SCHEMBL3157352

COc1ccc(S(=O)(=O)O)c([N+](=O)[O-])c1.O

nearest known ligand 0.51

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO

The experimentally established mechanism targets of Water. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 known ✓ O00255 2/20 0.47
POLB P06746 1/20 0.51
MCOLN3 Q8TDD5 1/20 0.51
ALDH1A1 P00352 5/20 0.49
LMNA P02545 2/20 0.49
MAPK1 P28482 4/20 0.49
SLC40A1 Q9NP59 1/20 0.48
RELA Q04206 1/20 0.47
KMT2A Q03164 2/20 0.47
VCAM1 P19320 1/20 0.47
MAPT P10636 4/20 0.46
RAB9A P51151 2/20 0.46
SMN1; SMN2 Q16637 2/20 0.46
KDM4E B2RXH2 1/20 0.46
NPC1 O15118 1/20 0.46
AKR1C3 P42330 2/20 0.45
AKR1C2 P52895 2/20 0.45
RAF1 P04049 1/20 0.43
HPGD P15428 1/20 0.43
GFER P55789 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3906545 0.98 POLB (0.52) POLBMCOLN3ALDH1A1LMNAMAPK1
Hydrochloric Acid SCHEMBL27447923 0.97 POLB (0.51) POLBMCOLN3ALDH1A1LMNAMAPK1
SCHEMBL10350813 0.86 ALDH1A1 (0.47) POLBMCOLN3ALDH1A1LMNAMAPK1
SCHEMBL6038596 0.86 POLB (0.52) POLBMCOLN3ALDH1A1LMNAMAPK1
SCHEMBL3919900 0.84 VCAM1 (0.60) POLBMCOLN3ALDH1A1LMNAMAPK1
SCHEMBL8960247 0.84 POLB (0.53) POLBMCOLN3ALDH1A1LMNAMAPK1
Hydrochloric Acid SCHEMBL27294434 0.84 ALDH1A1 (0.44) POLBMCOLN3ALDH1A1LMNAMAPK1
SCHEMBL6038599 0.83 POLB (0.52) POLBMCOLN3ALDH1A1LMNAMAPK1
SCHEMBL540736 0.83 POLB (0.52) POLBMCOLN3ALDH1A1LMNAMAPK1
SCHEMBL19071890 0.82 MAPT (0.46) POLBLMNAMEN1KMT2AVCAM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 150 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3426781-B1 MICRORNAS AND METHODS OF THEIR USE US HEALTH (US) 2024-06-26 EP disclosed
US-20230295631-A1 MICRORNAS AND METHODS OF THEIR USE THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES (US) 2023-09-21 US disclosed
US-20230226013-A1 COMPOSITION AND METHOD FOR TREATING CANCER Carmel-Haifa University Economic Corp Ltd. (IL) 2023-07-20 US disclosed
EP-3834882-B1 TREATING CANCER USING ELECTROMAGNETIC FIELDS IN COMBINATION WITH OTHER TREATMENT REGIMENS NOVOCURE GMBH (CH) 2023-07-19 EP disclosed
US-11690810-B2 Combination treatment of bacterial infection THE CHINESE UNIVERSITY OF HONG KONG (CN) 2023-07-04 US disclosed
US-11655469-B2 MicroRNAs and methods of their use THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2023-05-23 US disclosed
EP-3834882-A1 TREATING CANCER USING ELECTROMAGNETIC FIELDS IN COMBINATION WITH OTHER TREATMENT REGIMENS Novocure GmbH (CH) 2021-06-16 EP disclosed
WO-2021111443-A1 COMPOSITION AND METHOD FOR TREATING CANCER CARMEL - HAIFA UNIVERSITY ECONOMIC CORP LTD. (IL) 2021-06-10 WO disclosed
EP-3386596-B1 TOPICAL SKIN CARE COMPOSITIONS COMPRISING MYRSINE AFRICANA EXTRACTS UNIV PRETORIA (ZA) 2021-05-12 EP disclosed
CN-112739207-A Liquid for preserving mammalian cells comprising an acarbose or stachyose 株式会社大塚制药工场 2021-04-30 CN disclosed
EP-0935415-A4 METHODS FOR DELIVERING COMPOUNDS INTO A CELL IMARX PHARMACEUTICAL CORP (US) 2002-08-14 EP disclosed
EP-1218494-A2 COMPOSITIONS AND METHODS FOR INHIBITING G2 CELL CYCLE ARREST AND SENSITIZING CELLS TO DNA DAMAGING AGENTS Canbas Co., Ltd. (JP) 2002-07-03 EP disclosed
US-20010031740-A1 Methods for delivering compounds into a cell IMARX PHARMACEUTICAL CORPORATION 2001-10-18 US disclosed
WO-2001021771-A2 COMPOSITIONS AND METHODS FOR INHIBITING G2 CELL CYCLE ARREST AND SENSITIZING CELLS TO DNA DAMAGING AGENTS CANBAS CO., LTD. (US) 2001-03-29 WO disclosed
WO-2000003245-A1 PEPTIDE LIGANDS FOR THE HUMAN FIBROBLAST GROWTH FACTOR (FGF) RECEPTOR CHUGAI PHARMACEUTICAL COMPANY LIMITED (JP) 2000-01-20 WO disclosed
WO-1999047151-A1 PEPTIDE LIGANDS FOR THE ERYTHROPOIETIN RECEPTOR CHUGAI PHARMACEUTICAL CO., LTD. (JP) 1999-09-23 WO disclosed
EP-0935415-A1 METHODS FOR DELIVERING COMPOUNDS INTO A CELL IMARX PHARMACEUTICAL CORP. (US) 1999-08-18 EP disclosed
WO-1998020037-A1 METHOD FOR TREATING CERTAIN PEDIATRIC ACUTE LEUKEMIAS EMORY UNIVERSITY (US) 1998-05-14 WO disclosed
US-5698193-A ADMINISTERING IN OVO AN IMMUNE LYMPHOKINE OBTAINED FROM A DONOR ANIMAL THAT HAS BEEN IMMUNIZED WITH AN IMMUNOGEN THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF AGRICULTURE (US) 1997-12-16 US disclosed
WO-1997040679-A1 METHODS FOR DELIVERING COMPOUNDS INTO A CELL IMARX PHARMACEUTICAL CORP. (US) 1997-11-06 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11690810-B2 Combination treatment of bacterial infection PGC, NRDC, PYCARD MEN1 4072/4885POLB 1406/4885MCOLN3 3774/4885
US-20010031740-A1 Methods for delivering compounds into a cell ABCB4, NPC1L1, IAPP MEN1 1692/4885POLB 1755/4885MCOLN3 2655/4885
US-20230226013-A1 COMPOSITION AND METHOD FOR TREATING CANCER CYCS, SOX18, RPS8 MEN1 3283/4885POLB 978/4885MCOLN3 2862/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.