Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC known ✓ | P12931 | 1/20 | 0.41 |
| ▸ | PARP1 known ✓ | P09874 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 6/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | BLM | P54132 | 2/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3128833 | 0.98 | CES1 (0.45) | CES1ALDH1A1HIF1AMAPK1TRPA1 | |
| SCHEMBL9076470 | 0.81 | CES1 (0.47) | CES1ALDH1A1MAPK1SRCCYP2C19 | |
| Hydrochloric Acid SCHEMBL758628 | 0.81 | CES1 (0.47) | CES1ALDH1A1HIF1AMAPK1TRPA1 | |
| SCHEMBL9559864 | 0.79 | CES1 (0.45) | CES1ALDH1A1HIF1AMAPK1GSK3B | |
| SCHEMBL3345472 | 0.79 | CYP2C19 (0.50) | CES1ALDH1A1HIF1AMAPK1SRC | |
| SCHEMBL5695380 | 0.79 | CES1 (0.45) | CES1ALDH1A1HIF1AMAPK1SRC | |
| SCHEMBL3132247 | 0.79 | CES1 (0.48) | CES1ALDH1A1HIF1AMAPK1TRPA1 | |
| SCHEMBL10876359 | 0.79 | CES1 (0.48) | CES1ALDH1A1HIF1AMAPK1TRPA1 | |
| SCHEMBL3128812 | 0.78 | CES1 (0.44) | CES1ALDH1A1MAPK1SRCCYP2C19 | |
| SCHEMBL7637171 | 0.77 | SRC (0.47) | CES1ALDH1A1HIF1AMAPK1TRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8093241-B2 | Acid amide derivatives, process for their production and pesticides containing them | ISHIHARA SANGYO KAISHA, LTD. (JP) | 2012-01-10 | — | — | US | disclosed |
| EP-1256569-B1 | PHENACYLAMINE DERIVATIVES, PRODUCTION THEREOF AND PEST CONTROLLERS CONTAINING THE DERIVATIVES | ISHIHARA SANGYO KAISHA (JP) | 2010-07-07 | — | — | EP | disclosed |
| US-20100093707-A1 | ACID AMIDE DERIVATIVES, PROCESS FOR THEIR PRODUCTION AND PESTICIDES CONTAINING THEM | ISHIHARA SANGYO KAISHA, LTD. (JP) | 2010-04-15 | — | — | US | disclosed |
| US-7683096-B2 | Acid amide derivatives, process for producing these, and pest control agent containing these | ISHIHARA SANGYO KAISHA, LTD. (JP) | 2010-03-23 | — | — | US | disclosed |
| US-7439366-B2 | Phenacylamine derivatives, process for their production and pesticides containing them | ISHIHARA SANGYO KAISHA LTD. (JP) | 2008-10-21 | — | — | US | disclosed |
| US-20040254237-A1 | Acid amide derivatives, process for producing these, and pest agent containing these | ISHIHARA SANGYO KAISHA LTD. (JP) | 2004-12-16 | — | — | US | disclosed |
| EP-1428817-A1 | ACID AMIDE DERIVATIVES, PROCESS FOR PRODUCING THESE, AND PEST CONTROL AGENT CONTAINING THESE | ISHIHARA SANGYO KAISHA, LTD. (JP) | 2004-06-16 | — | — | EP | disclosed |
| US-20030153464-A1 | Phenacylamin derivatives, production thereof and pest controllers containing the derivatives | ISHIHARA SANGYO KAISHA LTD. (JP) | 2003-08-14 | — | — | US | disclosed |
| EP-1256569-A1 | PHENACYLAMINE DERIVATIVES, PRODUCTION THEREOF AND PEST CONTROLLERS CONTAINING THE DERIVATIVES | ISHIHARA SANGYO KAISHA, LTD. (JP) | 2002-11-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100093707-A1 | ACID AMIDE DERIVATIVES, PROCESS FOR THEIR PRODUCTION AND PESTICIDES CONTAINING THEM | NAA15, SAP18, CYP2C18 | SRC 2405/4885PARP1 4625/4885CES1 593/4885 |
| US-20040254237-A1 | Acid amide derivatives, process for producing these, and pest agent containing these | NAA15, CBR3, CBR1 | SRC 1611/4885PARP1 4536/4885CES1 729/4885 |
| US-20030153464-A1 | Phenacylamin derivatives, production thereof and pest controllers containing the derivatives | SCN4A, NAT1, HCN4 | SRC 631/4885PARP1 4299/4885CES1 761/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.