Hydrochloric Acid

Hydrochloric Acid

SCHEMBL3793595

Cl.O=C(O)C1CC(C(=O)O)C(C(=O)O)C1C(=O)O

nearest known ligand 0.94

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GABRR1 P24046 5/20 0.48
POLB P06746 3/20 0.40
TDP1 Q9NUW8 2/20 0.40
GABRR2 P28476 1/20 0.40
LMNA P02545 5/20 0.38
PMP22 Q01453 3/20 0.38
APEX1 P27695 2/20 0.38
KDM4E B2RXH2 2/20 0.38
TSHR P16473 2/20 0.38
GMNN O75496 1/20 0.38
TFPI2 P48307 1/20 0.38
TP53 P04637 1/20 0.38
NFKB1 P19838 1/20 0.38
THPO P40225 1/20 0.38
CYP2C19 P33261 2/20 0.37
MEN1 O00255 2/20 0.37
KMT2A Q03164 2/20 0.37
CYP2C9 P11712 1/20 0.37
GRM8 O00222 1/20 0.37
GRM6 O15303 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2697233 0.97 GABRR1 (0.50) GABRR1POLBTDP1GABRR2LMNA
SCHEMBL503468 0.97 GABRR1 (0.50) GABRR1POLBTDP1GABRR2LMNA
SCHEMBL2696513 0.97 GABRR1 (0.50) GABRR1POLBTDP1GABRR2LMNA
SCHEMBL8628131 0.97 GABRR1 (0.50) GABRR1POLBTDP1GABRR2LMNA
SCHEMBL13084744 0.97 GABRR1 (0.50) GABRR1POLBTDP1GABRR2LMNA
SCHEMBL770971 0.97 GABRR1 (0.50) GABRR1POLBTDP1GABRR2LMNA
SCHEMBL9782991 0.97 GABRR1 (0.50) GABRR1POLBTDP1GABRR2LMNA
SCHEMBL22039 0.97 GABRR1 (0.50) GABRR1POLBTDP1GABRR2LMNA
SCHEMBL11439800 0.94 GABRR1 (0.48) GABRR1POLBTDP1GABRR2LMNA
Hydrochloric Acid SCHEMBL2885177 0.94 GABRR1 (0.48) GABRR1POLBTDP1GABRR2LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0527348-B1 Interfacially synthesized reverse osmosis membranes and processes for preparing the same HYDRANAUTICS (US) 2000-09-27 EP claimed
US-5254261-A Water permeable polyimides or polyamideimides HYDRANAUTICS (US) 1993-10-19 US claimed
US-5246587-A Polycarbamate polymers from trifunctional cyclic chloroformate and polyamine to form membranes for desalting water HYDRANAUTICS (US) 1993-09-21 US claimed
EP-0527348-A1 Interfacially synthesized reverse osmosis membranes and processes for preparing the same HYDRANAUTICS (US) 1993-02-17 EP claimed
US-10780401-B2 Highly selective alicyclic polyamide nanofiltration membrane and making method thereof CHINA UNIVERSITY OF PETROLEUM (EAST CHINA) (CN) 2020-09-22 US disclosed
US-10207230-B2 Composite membrane with support comprising poly(phenylene ether) and amphilphilic polymer; method of making; and separation module thereof SABIC GLOBAL TECHNOLOGIES B.V. (NL) 2019-02-19 US disclosed
US-20180326362-A1 Highly selective alicyclic polyamide nanofiltration membrane and making method thereof CHINA UNIVERSITY OF PETROLEUM (EAST CHINA) (CN) 2018-11-15 US disclosed
US-9890351-B2 Encapsulates THE PROCTER & GAMBLE COMPANY (US) 2018-02-13 US disclosed
EP-2741731-B1 ENCAPSULATES PROCTER & GAMBLE (US) 2017-05-17 EP disclosed
EP-3137200-A1 COMPOSITE MEMBRANE WITH SUPPORT COMPRISING POLY(PHENYLENE ETHER) AND AMPHILPHILIC POLYMER; METHOD OF MAKING; AND SEPARATION MODULE THEREOF SABIC Global Technologies B.V. (NL) 2017-03-08 EP disclosed
US-20170043301-A1 COMPOSITE MEMBRANE WITH SUPPORT COMPRISING POLY(PHENYLENE ETHER) AND AMPHILPHILIC POLYMER; METHOD OF MAKING; AND SEPARATION MODULE THEREOF SABIC GLOBAL TECHNOLOGIES B.V. (NL) 2017-02-16 US disclosed
CN-101821089-B Polymeric membranes incorporating nanotubes UNIV SINGAPORE 2014-12-10 CN disclosed
EP-0527348-B1 Interfacially synthesized reverse osmosis membranes and processes for preparing the same HYDRANAUTICS (US) 2000-09-27 EP disclosed
US-5922203-A AMINE COMPOUND REACTED WITH ACYL HALIDE FOR MEMBRANES HYDRANAUTICS (US) 1999-07-13 US disclosed
US-5510527-A Acid chloride NITTO DENKO CORPORATION (JP) 1996-04-23 US disclosed
US-5336409-A Composite reverse osmosis membrane and novel acid chloride NITTO DENKO CORPORATION (JP) 1994-08-09 US disclosed
US-5254261-A Water permeable polyimides or polyamideimides HYDRANAUTICS (US) 1993-10-19 US disclosed
US-5246587-A Polycarbamate polymers from trifunctional cyclic chloroformate and polyamine to form membranes for desalting water HYDRANAUTICS (US) 1993-09-21 US disclosed
EP-0556569-A2 Composite reverse osmosis membrane and novel acid chloride NITTO DENKO CORPORATION (JP) 1993-08-25 EP disclosed
EP-0527348-A1 Interfacially synthesized reverse osmosis membranes and processes for preparing the same HYDRANAUTICS (US) 1993-02-17 EP disclosed