Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Histidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 known ✓ | Q9Y5N1 | 3/20 | 0.59 |
| ▸ | GLA known ✓ | P06280 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.97 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.97 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | APEX1 | P27695 | 1/20 | 0.59 |
| ▸ | BLM | P54132 | 1/20 | 0.59 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.56 |
| ▸ | THPO | P40225 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Histidine SCHEMBL16893960 | 1.00 | CYP3A4 (0.97) | CYP3A4SLC7A5ALDH1A1HRH4HRH3 | |
| D-Histidine SCHEMBL8002459 | 1.00 | CYP3A4 (0.97) | CYP3A4SLC7A5ALDH1A1HRH4HRH3 | |
| Histidine SCHEMBL5134199 | 1.00 | CYP3A4 (0.97) | CYP3A4SLC7A5ALDH1A1HRH4HRH3 | |
| Histidine SCHEMBL209484 | 1.00 | CYP3A4 (0.97) | CYP3A4SLC7A5ALDH1A1HRH4HRH3 | |
| Histidine SCHEMBL2228758 | 1.00 | CYP3A4 (0.97) | CYP3A4SLC7A5ALDH1A1HRH4HRH3 | |
| Histidine SCHEMBL357639 | 0.98 | CYP3A4 (0.93) | CYP3A4SLC7A5ALDH1A1HRH4HRH3 | |
| Histidine SCHEMBL31618930 | 0.98 | CYP3A4 (0.93) | CYP3A4SLC7A5ALDH1A1HRH4HRH3 | |
| Histidine SCHEMBL1705391 | 0.98 | CYP3A4 (0.93) | CYP3A4SLC7A5ALDH1A1HRH4HRH3 | |
| Histidine SCHEMBL28330064 | 0.98 | CYP3A4 (0.93) | CYP3A4SLC7A5ALDH1A1HRH4HRH3 | |
| D-Histidine SCHEMBL3639231 | 0.98 | CYP3A4 (0.93) | CYP3A4SLC7A5ALDH1A1HRH4HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 149 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3997056-A1 | NEW METHOD FOR PREPARING AN INSECT REPELLENT AGENT | Centre national de la recherche scientifique (FR) | 2022-05-18 | — | — | EP | claimed |
| WO-2021005214-A1 | NEW METHOD FOR PREPARING AN INSECT REPELLENT AGENT | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2021-01-14 | — | — | WO | claimed |
| CN-106178988-B | A kind of polyvinylidene fluoride blending film of photosynthesis-carbon dioxide response and preparation method thereof | 台州学院 | 2019-09-24 | — | — | CN | claimed |
| EP-2739282-B1 | NEW USE OF L-HISTIDINE AND DERIVATIVES THEREOF | BRACCO IMAGING SPA (IT) | 2017-01-11 | — | — | EP | claimed |
| CN-103717220-B | The purposes of L-Histidine and derivative thereof | BRACCO IMAGING S.P.A. (IT) | 2016-05-11 | — | — | CN | claimed |
| US-9012483-B2 | Use of L-Histidine and derivatives thereof | BRACCO IMAGING S.P.A. (IT) | 2015-04-21 | — | — | US | claimed |
| EP-2739282-A1 | NEW USE OF L-HISTIDINE AND DERIVATIVES THEREOF | Bracco Imaging S.p.A (IT) | 2014-06-11 | — | — | EP | claimed |
| US-20140155449-A1 | NEW USE OF L-HISTIDINE AND DERIVATIVES THEREOF | BRACCO IMAGING S.P.A. (IT) | 2014-06-05 | — | — | US | claimed |
| CN-103717220-A | New use of L-histidine and derivatives thereof | BRACCO IMAGING SPA | 2014-04-09 | — | — | CN | claimed |
| WO-2013017475-A1 | NEW USE OF L-HISTIDINE AND DERIVATIVES THEREOF | BRACCO IMAGING SPA (IT) | 2013-02-07 | — | — | WO | claimed |
| EP-2554167-A1 | New use of l-histidine and derivatives thereof | Bracco Imaging S.p.A (IT) | 2013-02-06 | — | — | EP | claimed |
| CN-100394555-C | Method of second step polishing in copper CMP with a polishing fluid containing no oxidizing agent | CMP ROHM AND HAAS ELECTRONIC M (US) | 2008-06-11 | — | — | CN | claimed |
| EP-1526163-B1 | Method of second step polishing in copper CMP with a polishing fluid containing no oxidizing agent | ROHM & HAAS ELECT MAT (US) | 2007-08-08 | — | — | EP | claimed |
| US-20050090106-A1 | Method of second step polishing in copper CMP with a polishing fluid containing no oxidizing agent | ROHM AND HAAS ELECTRONIC MATERIALS CMP HOLDINGS, INC. | 2005-04-28 | — | — | US | claimed |
| EP-1526163-A1 | Method of second step polishing in copper CMP with a polishing fluid containing no oxidizing agent | Rohm and Haas Electronic Materials CMP Holdings, Inc. (US) | 2005-04-27 | — | — | EP | claimed |
| CN-1610072-A | Method of second step polishing in copper CMP with a polishing fluid containing no oxidizing agent | CMP ROHM AND HAAS ELECTRONIC M (US) | 2005-04-27 | — | — | CN | claimed |
| US-20030065239-A1 | Non-hazardous basic neutralization of aldehydes | ETHICON, INC. | 2003-04-03 | — | — | US | claimed |
| EP-0513361-B1 | METHOD OF ASSAYING ENDOTOXIN | SEIKAGAKU KOGYO CO LTD (JP) | 1996-12-04 | — | — | EP | claimed |
| US-5378610-A | Surfactants, incubation and analyzing for endotoxins | SEIKAGAKU KOGYO KABUSHIKI KAISHA (SEIKAGAKU CORPORATION) (JP) | 1995-01-03 | — | — | US | claimed |
| EP-0513361-A1 | METHOD OF ASSAYING ENDOTOXIN | SEIKAGAKU KOGYO KABUSHIKI KAISHA (SEIKAGAKU CORPORATION) (JP) | 1992-11-19 | — | — | EP | claimed |