Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 known ✓ | Q12809 | 1/20 | 0.40 |
| ▸ | MAOB known ✓ | P27338 | 1/20 | 0.39 |
| ▸ | OPRK1 known ✓ | P41145 | 1/20 | 0.37 |
| ▸ | SLC6A1 known ✓ | P30531 | 2/20 | 0.35 |
| ▸ | PRKCZ known ✓ | Q05513 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | SLC6A11 | P48066 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | SLC6A13 | Q9NSD5 | 1/20 | 0.35 |
| ▸ | APLNR | P35414 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | NOS2 | P35228 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9790139 | 1.00 | — | — | |
| SCHEMBL3318759 | 0.98 | — | — | |
| SCHEMBL907956 | 0.98 | — | — | |
| SCHEMBL907697 | 0.98 | — | — | |
| SCHEMBL23746976 | 0.91 | — | — | |
| SCHEMBL1488235 | 0.91 | — | — | |
| SCHEMBL18256815 | 0.91 | — | — | |
| SCHEMBL19453678 | 0.88 | KCNH2 (0.39) | KCNH2KDM1AMAOBMAPK1OPRK1 | |
| Hydrochloric Acid SCHEMBL31691858 | 0.85 | — | — | |
| Hydrochloric Acid SCHEMBL584603 | 0.85 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115819402-A | Preparation method of balofloxacin | 无锡福祈制药有限公司 | 2023-03-21 | — | — | CN | claimed |
| CN-114213392-A | Balofloxacin raw material medicine and preparation process thereof | 华裕(无锡)制药有限公司 | 2022-03-22 | — | — | CN | claimed |
| CN-104557859-A | Preparation method of balofloxacin | UNIV HENAN NORMAL | 2015-04-29 | — | — | CN | claimed |
| CN-121342737-A | Preparation method of barofloxacin key intermediate 3-methylaminopiperidine dihydrochloride | 江苏联环药业股份有限公司 | 2026-01-16 | — | — | CN | disclosed |
| CN-121342737-A | Preparation method of barofloxacin key intermediate 3-methylaminopiperidine dihydrochloride | 江苏联环药业股份有限公司 | 2026-01-16 | — | — | CN | disclosed |
| CN-115819402-A | Preparation method of balofloxacin | 无锡福祈制药有限公司 | 2023-03-21 | — | — | CN | disclosed |
| CN-115819402-A | Preparation method of balofloxacin | 无锡福祈制药有限公司 | 2023-03-21 | — | — | CN | disclosed |
| CN-114213392-A | Balofloxacin raw material medicine and preparation process thereof | 华裕(无锡)制药有限公司 | 2022-03-22 | — | — | CN | disclosed |
| CN-103113290-B | Preparation method of Balofloxacin intermediate | ZHEJIANG APELOA KANGYU PHARMACEUTICAL CO LTD | 2015-06-03 | — | — | CN | disclosed |
| CN-104557859-A | Preparation method of balofloxacin | UNIV HENAN NORMAL | 2015-04-29 | — | — | CN | disclosed |
| CN-104557859-A | Preparation method of balofloxacin | UNIV HENAN NORMAL | 2015-04-29 | — | — | CN | disclosed |
| US-5910498-A | NOVEL COMPOUNDS HAVING REDUCED CYTOTOXICITY, PHOTOTOXICITY; TREATING BACTERIAL AND VIRAL INFECTIONS | WAKUNAGA SEIYAKU KABUSHIKI KAISHA (JP) | 1999-06-08 | — | — | US | disclosed |
| US-5869661-A | CONDENSING A 6-FLUOROQUINOLONECARBOXYLIC ACID WITH A SATURATED HETEROCYCLIC AMINE WITH OR WITHOUT A SOLVENT | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 1999-02-09 | — | — | US | disclosed |
| EP-0787720-A1 | NOVEL PYRIDONECARBOXYLATE DERIVATIVE OR SALT THEREOF AND ANTIBACTERIAL CONTAINING THE SAME AS ACTIVE INGREDIENT | WAKUNAGA SEIYAKU KABUSHIKI KAISHA (JP) | 1997-08-06 | — | — | EP | disclosed |
| US-5597923-A | STABILITY, MICROBIOCIDES | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 1997-01-28 | — | — | US | disclosed |
| EP-0641782-A1 | PROCESS FOR PRODUCING QUINOLONECARBOXYLIC ACID DERIVATIVE | Chugai Seiyaku Kabushiki Kaisha (JP) | 1995-03-08 | — | — | EP | disclosed |
| EP-0342675-B1 | Novel quinolonecarboxylic acid derivatives | CHUGAI PHARMACEUTICAL CO LTD (JP) | 1995-01-25 | — | — | EP | disclosed |
| EP-0629621-A1 | CRYSTAL OF QUINOLONECARBOXYLIC ACID DERIVATIVE HYDRATE | Chugai Seiyaku Kabushiki Kaisha (JP) | 1994-12-21 | — | — | EP | disclosed |
| US-5051509-A | Antibiotics | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 1991-09-24 | — | — | US | disclosed |
| EP-0342675-A2 | Novel quinolonecarboxylic acid derivatives | Chugai Seiyaku Kabushiki Kaisha (JP) | 1989-11-23 | — | — | EP | disclosed |