Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA known ✓ | P42336 | 1/20 | 0.52 |
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.40 |
| ▸ | CA2 known ✓ | P00918 | 1/20 | 0.39 |
| ▸ | DPP4 known ✓ | P27487 | 1/20 | 0.38 |
| ▸ | CD44 | P16070 | 1/20 | 0.94 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.62 |
| ▸ | TSHR | P16473 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA7 | P43166 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL300661 | 1.00 | CD44 (0.94) | CD44CYP3A4TDP1TSHRPIK3CA | |
| SCHEMBL42498 | 0.97 | — | — | |
| SCHEMBL29363854 | 0.97 | — | — | |
| SCHEMBL27995928 | 0.97 | CD44 (1.00) | CD44CYP3A4TDP1TSHRPIK3CA | |
| Water SCHEMBL3857839 | 0.94 | CD44 (0.94) | CD44CYP3A4TDP1TSHRPIK3CA | |
| Hydrogen Sulfide SCHEMBL28874707 | 0.94 | CD44 (0.94) | CD44CYP3A4TDP1TSHRPIK3CA | |
| SCHEMBL28535612 | 0.94 | CD44 (0.94) | CD44CYP3A4TDP1TSHRPIK3CA | |
| Ethylene SCHEMBL1827345 | 0.92 | CD44 (0.90) | CD44CYP3A4TDP1TSHRPIK3CA | |
| Methyl Alcohol SCHEMBL28133981 | 0.92 | CD44 (0.90) | CD44CYP3A4TDP1TSHRPIK3CA | |
| Hydrogen Peroxide SCHEMBL14358429 | 0.92 | CD44 (0.90) | CD44CYP3A4TDP1TSHRPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108774140-A | Synthesis method of N-methyl o-phenylenediamine hydrochloride | 海门市新港医药科技有限公司 | 2018-11-09 | — | — | CN | claimed |
| EP-1912975-A1 | A PROCESS FOR THE PREPARATION OF TELMISARTAN | Matrix Laboratories Ltd (IN) | 2008-04-23 | — | — | EP | claimed |
| WO-2007010558-A1 | A PROCESS FOR THE PREPARATION OF TELMISARTAN | MATRIX LABORATORIES LIMITED (IN) | 2007-01-25 | — | — | WO | claimed |
| EP-0002308-B1 | CATALYTIC HYDROGENATION PROCESS FOR THE MANUFACTURE OF AROMATIC AMINES | The Clayton Aniline Company Limited (GB) | 1982-03-17 | — | — | EP | claimed |
| US-4256671-A | Production of 2,4- and 2,6-diaminotoluenes | CLAYTON ANILINE COMPANY, LTD. (GB) | 1981-03-17 | — | — | US | claimed |
| CN-108774140-A | Synthesis method of N-methyl o-phenylenediamine hydrochloride | 海门市新港医药科技有限公司 | 2018-11-09 | — | — | CN | disclosed |
| CN-108774140-A | Synthesis method of N-methyl o-phenylenediamine hydrochloride | 海门市新港医药科技有限公司 | 2018-11-09 | — | — | CN | disclosed |
| CN-108774140-A | Synthesis method of N-methyl o-phenylenediamine hydrochloride | 海门市新港医药科技有限公司 | 2018-11-09 | — | — | CN | disclosed |
| CN-108129462-A | A kind of dioxolanyl benzimidazole compound and preparation method thereof | 广东工业大学 | 2018-06-08 | — | — | CN | disclosed |
| CN-104892573-B | Act on 3- vinyl-quinoxaline -2 (1H) -one derivative of FGFR-1 and its preparation method and application | 温州医科大学 | 2018-05-29 | — | — | CN | disclosed |
| CN-207126501-U | A kind of Flashmelt dehydration condensation reactor | 湖北工业大学 | 2018-03-23 | — | — | CN | disclosed |
| CN-102639512-A | Preparation method of benzo [ b ] [1,4] diaza-2, 4-dione compound | OTSUKA PHARMA CO LTD | 2012-08-15 | — | — | CN | disclosed |
| EP-1912975-A1 | A PROCESS FOR THE PREPARATION OF TELMISARTAN | Matrix Laboratories Ltd (IN) | 2008-04-23 | — | — | EP | disclosed |
| WO-2007010558-A1 | A PROCESS FOR THE PREPARATION OF TELMISARTAN | MATRIX LABORATORIES LIMITED (IN) | 2007-01-25 | — | — | WO | disclosed |
| EP-0002308-B1 | CATALYTIC HYDROGENATION PROCESS FOR THE MANUFACTURE OF AROMATIC AMINES | The Clayton Aniline Company Limited (GB) | 1982-03-17 | — | — | EP | disclosed |
| US-4256671-A | Production of 2,4- and 2,6-diaminotoluenes | CLAYTON ANILINE COMPANY, LTD. (GB) | 1981-03-17 | — | — | US | disclosed |