Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Trimethylammonium. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.62 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | APEX1 | P27695 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trimethylammonium SCHEMBL5242715 | 0.98 | TSHR (0.64) | TSHRTHRBALDH1A1MAPTPOLB | |
| Methacrylic Acid SCHEMBL25184921 | 0.95 | TSHR (0.56) | TSHRTHRBALDH1A1MAPTPOLB | |
| Hydrochloric Acid SCHEMBL27495672 | 0.94 | TSHR (0.69) | TSHRTHRBALDH1A1MAPTPOLB | |
| SCHEMBL19017 | 0.92 | TSHR (0.72) | TSHRTHRBALDH1A1MAPTPOLB | |
| SCHEMBL9695772 | 0.92 | TSHR (0.72) | TSHRTHRBALDH1A1MAPTPOLB | |
| Isobutane SCHEMBL28146334 | 0.90 | TSHR (0.69) | TSHRTHRBALDH1A1MAPTPOLB | |
| Ammonia Solution, Strong SCHEMBL28645738 | 0.90 | TSHR (0.69) | TSHRTHRBALDH1A1MAPTPOLB | |
| Methoxymethane SCHEMBL5841853 | 0.88 | TSHR (0.67) | TSHRTHRBALDH1A1MAPTPOLB | |
| Methylamine SCHEMBL27537685 | 0.88 | TSHR (0.67) | TSHRTHRBALDH1A1MAPTPOLB | |
| Methacrylic Acid SCHEMBL1076438 | 0.86 | TSHR (0.64) | TSHRTHRBALDH1A1MAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 138 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2828692-B1 | HYDROPHILIC MACROMERS AND HYDROGELS COMPRISING THE SAME | MOMENTIVE PERFORMANCE MAT INC (US) | 2024-02-28 | — | — | EP | claimed |
| CN-116438252-A | Contact lens and method for manufacturing same | 晶硕光学股份有限公司 | 2023-07-14 | — | — | CN | claimed |
| WO-2023082166-A1 | CONTACT LENS AND MANUFACTURING METHOD THEREFOR | 晶硕光学股份有限公司 | 2023-05-19 | — | — | WO | claimed |
| CN-110431203-B | Ionically modified silicones, compositions, and medical devices formed therefrom | 莫门蒂夫性能材料股份有限公司 | 2021-11-02 | — | — | CN | claimed |
| CN-110494519-B | Ionically modified silicones, compositions, and medical devices formed therefrom | 莫门蒂夫性能材料股份有限公司 | 2021-10-26 | — | — | CN | claimed |
| EP-3583177-B1 | IONICALLY MODIFIED SILICONES, COMPOSITIONS, AND MEDICAL DEVICES FORMED THEREFROM | MOMENTIVE PERFORMANCE MAT INC (US) | 2020-12-23 | — | — | EP | claimed |
| EP-3583176-B1 | IONICALLY MODIFIED SILICONES, COMPOSITIONS, AND MEDICAL DEVICES FORMED THEREFROM | MOMENTIVE PERFORMANCE MAT INC (US) | 2020-12-16 | — | — | EP | claimed |
| CN-105334640-B | Silicone hydrogel lenses with rich water surface | 诺华股份有限公司 | 2018-12-28 | — | — | CN | claimed |
| EP-2264486-B1 | Ophthalmic, tinted molding composition, molding having high Dk-value and method of its production | NOVARTIS AG (CH) | 2018-08-22 | — | — | EP | claimed |
| CN-103298602-A | Method for making silicone hydrogel contact lenses | NOVARTIS AG | 2013-09-11 | — | — | CN | claimed |
| US-20090269392-A1 | Drug Delivery System And Methods Of Use | Ocugenics, LLC | 2009-10-29 | — | — | US | claimed |
| US-20090096985-A1 | Tinted, high DK ophthalmic molding and a method for making same | ALCON INC. (CH) | 2009-04-16 | — | — | US | claimed |
| CN-100374169-C | Method of manufacturing antimicrobial medical devices | NOVARTIS AG (CH) | 2008-03-12 | — | — | CN | claimed |
| CN-1822867-A | antibacterial medical equipment | NOVARTIS AG (CH) | 2006-08-23 | — | — | CN | claimed |
| US-20040157276-A1 | Agglutination accelerator for immunological measurement | WAKO PURE CHEMICALS INDUSTRIES, LTD. (JP) | 2004-08-12 | — | — | US | claimed |
| JP-2004517360-A | — | — | 2004-06-10 | — | — | JP | claimed |
| CN-1484771-A | A tinted high dk ophthalmic molding and a method for making same | ��˹��ŵ�� | 2004-03-24 | — | — | CN | claimed |
| EP-1360527-A2 | A TINTED, HIGH DK OPHTHALMIC MOLDING AND A METHOD FOR MAKING SAME | Novartis AG (CH) | 2003-11-12 | — | — | EP | claimed |
| WO-2002054136-A2 | A TINTED, HIGH DK OPHTHALMIC MOLDING AND A METHOD FOR MAKING SAME | NOVARTIS AG (CH) | 2002-07-11 | — | — | WO | claimed |
| EP-0490940-B2 | PROCESS FOR GRAFTING OF NITROGEN-CONTAINING POLYMERS, AND POLYMERS THUS OBTAINED | SARTORIUS GMBH (DE) | 2000-07-05 | — | — | EP | claimed |