Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 6/20 | 1.00 |
| ▸ | TOP2B | Q02880 | 6/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.87 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.87 |
| ▸ | HPGD | P15428 | 1/20 | 0.87 |
| ▸ | CASP1 | P29466 | 1/20 | 0.87 |
| ▸ | CASP7 | P55210 | 1/20 | 0.87 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.87 |
| ▸ | NISCH | Q9Y2I1 | 7/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | RECQL | P46063 | 1/20 | 0.59 |
| ▸ | HTR1D | P28221 | 1/20 | 0.56 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7734250 | 0.96 | TOP2A (0.96) | TOP2ATOP2BALDH1A1CYP1A2HPGD | |
| SCHEMBL7724230 | 0.89 | TOP2A (1.00) | TOP2ATOP2BALDH1A1CYP1A2HPGD | |
| SCHEMBL14089880 | 0.87 | NISCH (0.79) | TOP2ATOP2BALDH1A1CYP1A2HPGD | |
| SCHEMBL549191 | 0.87 | TOP2A (1.00) | TOP2ATOP2BALDH1A1CYP1A2HPGD | |
| Hydrochloric Acid SCHEMBL7734128 | 0.86 | TOP2A (1.00) | TOP2ATOP2BALDH1A1CYP1A2HPGD | |
| SCHEMBL5476725 | 0.85 | NISCH (0.79) | TOP2ATOP2BALDH1A1CYP1A2HPGD | |
| Furaline SCHEMBL11783413 | 0.84 | ALDH1A1 (0.84) | TOP2ATOP2BALDH1A1CYP1A2HPGD | |
| Hydrochloric Acid SCHEMBL11755591 | 0.83 | TOP2A (0.73) | TOP2ATOP2BALDH1A1CYP1A2HPGD | |
| SCHEMBL13167096 | 0.82 | TOP2A (0.69) | TOP2ATOP2BALDH1A1CYP1A2HPGD | |
| SCHEMBL13167160 | 0.80 | ALDH1A1 (0.65) | TOP2ATOP2BALDH1A1CYP1A2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 107 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070099905-A1 | Combinations of drugs for the treatment of neoplasms | BORISY ALEXIS | 2007-05-03 | — | — | US | claimed |
| EP-1651211-A4 | COMBINATION OF DRUGS FOR THE TREATMENT OF NEOPLASMS | COMBINATORX INC (US) | 2006-11-22 | — | — | EP | claimed |
| CN-1829509-A | Pharmaceutical composition for treating tumors | COMBINATORX INC (US) | 2006-09-06 | — | — | CN | claimed |
| EP-1651211-A2 | COMBINATION OF DRUGS FOR THE TREATMENT OF NEOPLASMS | Combinatorx, Incorporated (US) | 2006-05-03 | — | — | EP | claimed |
| EP-1545544-A2 | COMBINATIONS OF DRUGS FOR THE TREATMENT OF NEOPLASMS | Combinatorx, Incorporated (US) | 2005-06-29 | — | — | EP | claimed |
| US-20050080075-A1 | Formulations, conjugates, and combinations of drugs for the treatment of neoplasms | COMBINATORX, INC. | 2005-04-14 | — | — | US | claimed |
| WO-2005020913-A2 | FORMULATIONS, CONJUGATES, AND COMBINATIONS OF DRUGS FOR THE TREATMENT OF NEOPLASMS | COMBINATORX, INCORPORATED (US) | 2005-03-10 | — | — | WO | claimed |
| US-20050054708-A1 | Combinations of drugs for the treatment of neoplasms | COMINATORX, INCORPORATED | 2005-03-10 | — | — | US | claimed |
| WO-2005011572-A2 | COMBINATION OF DRUGS FOR THE TREATMENT OF NEOPLASMS | COMBINATORX, INCORPORATED (US) | 2005-02-10 | — | — | WO | claimed |
| US-20040116407-A1 | Combinations of drugs for the treatment of neoplasms | COMBINATORX, INC. | 2004-06-17 | — | — | US | claimed |
| WO-2004006842-A2 | COMBINATIONS OF DRUGS FOR THE TREATMENT OF NEOPLASMS | COMBINATORX, INCORPORATED (US) | 2004-01-22 | — | — | WO | claimed |
| WO-2004006849-A2 | COMBINATIONS OF DRUGS FOR THE TREATMENT OF NEOPLASMS | COMBINATORX, INCORPORATED (US) | 2004-01-22 | — | — | WO | claimed |
| EP-0792271-B1 | FURAN DERIVATIVES FOR INHIBITING PNEUMOCYSTIS CARINII PNEUMONIA, GIARDIA LAMBLIA AND CRYPTOSPORIDIUM PARVUM | UNIV GEORGIA STATE RES FOUND (US) | 2002-02-27 | — | — | EP | claimed |
| JP-3098545-B2 | — | — | 2000-10-16 | — | — | JP | claimed |
| EP-0792271-A1 | FURAN DERIVATIVES FOR INHIBITING PNEUMOCYSTIS CARINII PNEUMONIA, GIARDIA LAMBLIA AND CRYPTOSPORIDIUM PARVUM | GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) | 1997-09-03 | — | — | EP | claimed |
| EP-0758453-A1 | METHOD OF FLUORESCENT DETECTION OF NUCLEIC ACIDS AND CYTOSKELETON ELEMENTS USING BIS-DICATIONIC ARYL FURANS | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1997-02-19 | — | — | EP | claimed |
| US-5602172-A | USING A 2,5-DIPHENYLFURAN COMPOUND | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1997-02-11 | — | — | US | claimed |
| WO-1996015126-A1 | FURAN DERIVATIVES FOR INHIBITING PNEUMOCYSTIS CARINII PNEUMONIA, GIARDIA LAMBLIA AND CRYPTOSPORIDIUM PARVUM | GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) | 1996-05-23 | — | — | WO | claimed |
| WO-1995030901-A1 | METHOD OF FLUORESCENT DETECTION OF NUCLEIC ACIDS AND CYTOSKELETON ELEMENTS USING BIS-DICATIONIC ARYL FURANS | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1995-11-16 | — | — | WO | claimed |
| EP-4295852-A2 | PIPERIDINE DERIVATIVES AS INHIBITORS OF CYCLIN DEPENDENT KINASE 7 (CDK7) | Syros Pharmaceuticals, Inc. (US) | 2023-12-27 | — | — | EP | disclosed |
| CN-114552025-B | Solid electrolyte, preparation method thereof and all-solid lithium metal battery | 中国地质大学（武汉） | 2023-12-22 | — | — | CN | disclosed |
| EP-1891013-B1 | TETRAHYDROQUINOLINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2014-07-23 | — | — | EP | disclosed |
| US-8524732-B2 | Substituted tetrahydroquinolines | MERCK PATENT GMBH (DE) | 2013-09-03 | — | — | US | disclosed |
| EP-2121700-B1 | SUBSTITUTED TETRAHYDROQUINOLINES | MERCK PATENT GMBH (DE) | 2012-10-03 | — | — | EP | disclosed |
| US-8207345-B2 | Antitumor agents; use in combination with other drugs such as pentamidine | MERCK PATENT GMBH (DE) | 2012-06-26 | — | — | US | disclosed |
| US-20120130147-A1 | METHODS FOR THE TREATMENT OF TUMORS WITH INDANE COMPOUNDS | FINSINGER DIRK (DE) | 2012-05-24 | — | — | US | disclosed |
| US-8110583-B2 | treatment of tumors; 1,5-bis(4'-(N-hydroxyamidino)phenoxy)pentane; maintain cells in the G2/M cell cycle | MERCK PATENT GMBH (DE) | 2012-02-07 | — | — | US | disclosed |
| EP-2033959-B1 | Tetrahydropyranoquinoline derivatives | MERCK PATENT GMBH (DE) | 2011-04-27 | — | — | EP | disclosed |
| US-7915416-B2 | Tetrahydroquinolines | MERCK PATENT GMBH (DE) | 2011-03-29 | — | — | US | disclosed |
| US-7893082-B2 | Antitumor agents; anticancer agents | MERCK PATENT GMBH (DE) | 2011-02-22 | — | — | US | disclosed |
| US-7875614-B2 | compounds for treatment of tumors | MERCK PATENT GMBH (DE) | 2011-01-25 | — | — | US | disclosed |
| US-7868172-B2 | 2-(hetero)-aryl substituted tetrahydroquinoline derivatives | MERCK PATENT GMBH (DE) | 2011-01-11 | — | — | US | disclosed |
| EP-1891011-B1 | TETRAHYDROQUINOLINES USED IN THE FORM OF MODULATORS OF MITOTIC MOTOR-PROTEINS EG5 | MERCK PATENT GMBH (DE) | 2010-12-08 | — | — | EP | disclosed |
| US-20100120818-A1 | SUBSTITUTED TETRAHYDROPYRROLOQUINOLINES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2010-05-13 | — | — | US | disclosed |
| US-20100076012-A1 | TETRAHYDROQUINOLINE DERIVATIVES AND THE USE THEREOF FOR THE TREATMENT OF CANCER | MERCK PATENT GMBH (DE) | 2010-03-25 | — | — | US | disclosed |
| US-20100022530-A1 | TETRAHYDROBENZOISOXAZOLE AND TETRAHYDROINDAZOLE DERIVATIVES AS MODULATORS OF THE MITOTIC MOTOR PROTEIN | MERCK PATENT GMBH (DE) | 2010-01-28 | — | — | US | disclosed |
| US-20100022579-A1 | SUBSTITUTED TETRAHYDROQUINOLINES | Merck Patent Gesellschaft mit bescrankter Haftung (DE) | 2010-01-28 | — | — | US | disclosed |
| EP-2121700-A1 | SUBSTITUTED TETRAHYDROQUINOLINES | Merck Patent GmbH (DE) | 2009-11-25 | — | — | EP | disclosed |
| EP-2121684-A1 | SUBSTITUTED TETRAHYDROPYRROLOQUINOLINES | Merck Patent GmbH (DE) | 2009-11-25 | — | — | EP | disclosed |
| EP-2104664-A1 | TETRAHYDROBENZOISOXAZOLE - AND TETRAHYDROINDAZOLE DERIVATIVES AS MODULATORS OF THE MITOTIC MOTOR PROTEIN | Merck Patent GmbH (DE) | 2009-09-30 | — | — | EP | disclosed |
| US-20090118267-A1 | INDANES | MERCK PATENT GMBH (DE) | 2009-05-07 | — | — | US | disclosed |
| EP-2033959-A1 | Tetrahydropyranoquinoline derivatives | Merck Patent GmbH (DE) | 2009-03-11 | — | — | EP | disclosed |
| US-20090030028-A1 | Tetrahydroquinolines | MERCK PATENT GMBH (DE) | 2009-01-29 | — | — | US | disclosed |
| EP-1761515-B1 | 2-(HETERO-)ARYL SUBSTITUTED TETRAHYDROQUINOLINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2008-11-05 | — | — | EP | disclosed |
| WO-2008113452-A1 | SUBSTITUTED TETRAHYDROPYRROLOQUINOLINES | MERCK PATENT GMBH (DE) | 2008-09-25 | — | — | WO | disclosed |
| WO-2008113451-A1 | SUBSTITUTED TETRAHYDROQUINOLINES | MERCK PATENT GMBH (DE) | 2008-09-25 | — | — | WO | disclosed |
| US-20080234299-A1 | Quinazolinones | MERCK PATENT GMBH (DE) | 2008-09-25 | — | — | US | disclosed |
| US-20080221118-A1 | treatment of tumors; 1,5-bis(4'-(N-hydroxyamidino)phenoxy)pentane; maintain cells in the G2/M cell cycle | MERCK PATENT GMBH (DE) | 2008-09-11 | — | — | US | disclosed |
| US-20080200451-A1 | Tetrahydroquinolines for Use as Modulators of the Mitotic Motor Protein Eg5 | MERCK PATENT GMBH (DE) | 2008-08-21 | — | — | US | disclosed |
| US-20080194569-A1 | Phthalazinones | MERCK PATENT GMBH (DE) | 2008-08-14 | — | — | US | disclosed |
| US-20080194615-A1 | Antitumor agents; anticancer agents | MERCK PATENT GMBH (DE) | 2008-08-14 | — | — | US | disclosed |
| WO-2008080455-A1 | TETRAHYDROBENZOISOXAZOLE - AND TETRAHYDROINDAZOLE DERIVATIVES AS MODULATORS OF THE MITOTIC MOTOR PROTEIN | MERCK PATENT GMBH (DE) | 2008-07-10 | — | — | WO | disclosed |
| EP-1891076-A1 | SUBSTITUTED TETRAHYDROQUINOLINES | Merck Patent GmbH (DE) | 2008-02-27 | — | — | EP | disclosed |
| EP-1891013-A1 | TETRAHYDROQUINOLINE DERIVATIVES | Merck Patent GmbH (DE) | 2008-02-27 | — | — | EP | disclosed |
| EP-1891011-A1 | TETRAHYDROQUINOLINES USED IN THE FORM OF MODULATORS OF MITOTIC MOTOR-PROTEINS EG5 | Merck Patent GmbH (DE) | 2008-02-27 | — | — | EP | disclosed |
| EP-1885702-A2 | QUINAZOLINONES | Merck Patent GmbH (DE) | 2008-02-13 | — | — | EP | disclosed |
| US-20070299043-A1 | Anti-scarring drug combinations and use thereof | HUNTER WILLIAM L | 2007-12-27 | — | — | US | disclosed |
| EP-1858860-A1 | PHTHALAZINONES | Merck Patent GmbH (DE) | 2007-11-28 | — | — | EP | disclosed |
| EP-1853550-A1 | INDANE | Merck Patent GmbH (DE) | 2007-11-14 | — | — | EP | disclosed |
| US-20070219246-A1 | Dihydrobenzothiophenes | MERCK PATENT GMBH (DE) | 2007-09-20 | — | — | US | disclosed |
| US-20070208134-A1 | Anti-scarring drug combinations and use thereof | HUNTER WILLIAM L | 2007-09-06 | — | — | US | disclosed |
| US-20070203167-A1 | 2-(Hetero)-aryl substituted tetrahydrochinoline | MERCK PATENT GMBH (DE) | 2007-08-30 | — | — | US | disclosed |
| US-20070196421-A1 | Soft tissue implants and drug combination compositions, and use thereof | ANGIOTECH INTERNATIONAL AG (CH) | 2007-08-23 | — | — | US | disclosed |
| US-20070198063-A1 | Electrical devices and anti-scarring drug combinations | HUNTER WILLIAM L | 2007-08-23 | — | — | US | disclosed |
| US-20070197957-A1 | Implantable sensors, implantable pumps and anti-scarring drug combinations | HUNTER WILLIAM L | 2007-08-23 | — | — | US | disclosed |
| WO-2007041677-A9 | SOFT TISSUE IMPLANTS AND DRUG COMBINATION COMPOSITIONS, AND USE THEREOF | COMBINATORX INC (US) | 2007-05-31 | — | — | WO | disclosed |
| WO-2007054138-A1 | SUBSTITUTED TETRAHYDROQUINOLINES | MERCK PATENT GMBH (DE) | 2007-05-18 | — | — | WO | disclosed |
| US-20070099905-A1 | Combinations of drugs for the treatment of neoplasms | BORISY ALEXIS | 2007-05-03 | — | — | US | disclosed |
| EP-1778694-A1 | TETRAHYDROQUINOLINES | Merck Patent GmbH (DE) | 2007-05-02 | — | — | EP | disclosed |
| WO-2007041463-A2 | ELECTRICAL DEVICES AND ANTI-SCARRING DRUG COMBINATIONS | COMBINATORX, INCORPORATED (US) | 2007-04-12 | — | — | WO | disclosed |
| WO-2007041593-A2 | ANTI-SCARRING DRUG COMBINATIONS AND USE THEREOF | COMBINATORX, INCORPORATED (US) | 2007-04-12 | — | — | WO | disclosed |
| WO-2007041677-A2 | SOFT TISSUE IMPLANTS AND DRUG COMBINATION COMPOSITIONS, AND USE THEREOF | COMBINATORX, INCORPORATED (US) | 2007-04-12 | — | — | WO | disclosed |
| WO-2007041584-A2 | IMPLANTABLE SENSORS, IMPLANTABLE PUMPS, AND ANTI-SCARRING DRUG COMBINATIONS | COMBINATORX, INCORPORATED (US) | 2007-04-12 | — | — | WO | disclosed |
| EP-1761515-A1 | 2-(HETERO-)ARYL SUBSTITUTED TETRAHYDROQUINOLINE DERIVATIVES | MERCK PATENT GmbH (DE) | 2007-03-14 | — | — | EP | disclosed |
| EP-1747214-A2 | DIHYDROBENZOTHIOPHENES | MERCK PATENT GmbH (DE) | 2007-01-31 | — | — | EP | disclosed |
| WO-2006133805-A1 | TETRAHYDROQUINOLINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2006-12-21 | — | — | WO | disclosed |
| WO-2006133821-A1 | TETRAHYDROQUINOLINES USED IN THE FORM OF MODULATORS OF MITOTIC MOTOR-PROTEINS EG5 | MERCK PATENT GMBH (DE) | 2006-12-21 | — | — | WO | disclosed |
| WO-2006125555-A2 | QUINAZOLINONES | MERCK PATENT GMBH (DE) | 2006-11-30 | — | — | WO | disclosed |
| EP-1651211-A4 | COMBINATION OF DRUGS FOR THE TREATMENT OF NEOPLASMS | COMBINATORX INC (US) | 2006-11-22 | — | — | EP | disclosed |
| WO-2006097176-A1 | PHTHALAZINONES | MERCK PATENT GMBH (DE) | 2006-09-21 | — | — | WO | disclosed |
| WO-2006094602-A1 | INDANE | MERCK PATENT GMBH (DE) | 2006-09-14 | — | — | WO | disclosed |
| EP-1670477-A2 | COMBINATIONS OF DRUGS FOR THE TREATMENT OF NEOPLASMS | CombinatoRx, Incorporated (US) | 2006-06-21 | — | — | EP | disclosed |
| EP-1651211-A2 | COMBINATION OF DRUGS FOR THE TREATMENT OF NEOPLASMS | Combinatorx, Incorporated (US) | 2006-05-03 | — | — | EP | disclosed |
| WO-2006002726-A1 | TETRAHYDROQUINOLINES | MERCK PATENT GMBH (DE) | 2006-01-12 | — | — | WO | disclosed |
| WO-2005108355-A2 | DIHYDROBENZOTHIOPHENES | MERCK PATENT GMBH (DE) | 2005-11-17 | — | — | WO | disclosed |
| CN-1681511-A | Combinations of drugs for the treatment of neoplasms | COMBINATORX INC (US) | 2005-10-12 | — | — | CN | disclosed |
| WO-2005063735-A1 | 2-(HETERO)-ARYL-SUBSTITUTED TETRAHYDROQUINOLINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2005-07-14 | — | — | WO | disclosed |
| EP-1545544-A2 | COMBINATIONS OF DRUGS FOR THE TREATMENT OF NEOPLASMS | Combinatorx, Incorporated (US) | 2005-06-29 | — | — | EP | disclosed |
| US-20050137185-A1 | Combinations of drugs for the treatment of neoplasms | COMBINATORX, INCORPORATED | 2005-06-23 | — | — | US | disclosed |
| US-20050080075-A1 | Formulations, conjugates, and combinations of drugs for the treatment of neoplasms | COMBINATORX, INC. | 2005-04-14 | — | — | US | disclosed |
| WO-2005027842-A2 | COMBINATIONS OF DRUGS FOR THE TREATMENT OF NEOPLASMS | COMBINATORX, INCORPORATED (US) | 2005-03-31 | — | — | WO | disclosed |
| WO-2005020913-A2 | FORMULATIONS, CONJUGATES, AND COMBINATIONS OF DRUGS FOR THE TREATMENT OF NEOPLASMS | COMBINATORX, INCORPORATED (US) | 2005-03-10 | — | — | WO | disclosed |
| US-20050054708-A1 | Combinations of drugs for the treatment of neoplasms | COMINATORX, INCORPORATED | 2005-03-10 | — | — | US | disclosed |
| WO-2005011572-A2 | COMBINATION OF DRUGS FOR THE TREATMENT OF NEOPLASMS | COMBINATORX, INCORPORATED (US) | 2005-02-10 | — | — | WO | disclosed |
| US-20040116407-A1 | Combinations of drugs for the treatment of neoplasms | COMBINATORX, INC. | 2004-06-17 | — | — | US | disclosed |
| WO-2004006842-A2 | COMBINATIONS OF DRUGS FOR THE TREATMENT OF NEOPLASMS | COMBINATORX, INCORPORATED (US) | 2004-01-22 | — | — | WO | disclosed |
| WO-2004006849-A2 | COMBINATIONS OF DRUGS FOR THE TREATMENT OF NEOPLASMS | COMBINATORX, INCORPORATED (US) | 2004-01-22 | — | — | WO | disclosed |
| WO-2004002430-A2 | COMBINATIONS FOR THE TREATMENT OF FUNGAL INFECTIONS | COMBINATORX INCORPORATED (US) | 2004-01-08 | — | — | WO | disclosed |
| EP-0792271-B1 | FURAN DERIVATIVES FOR INHIBITING PNEUMOCYSTIS CARINII PNEUMONIA, GIARDIA LAMBLIA AND CRYPTOSPORIDIUM PARVUM | UNIV GEORGIA STATE RES FOUND (US) | 2002-02-27 | — | — | EP | disclosed |
| US-5667975-A | Method of fluorescent detection of nucleic acids and cytoskeleton elements using bis-dicationic aryl furans | THE UNIVERSITY OF NORTH CAROLINA | 1997-09-16 | — | — | US | disclosed |
| EP-0792271-A1 | FURAN DERIVATIVES FOR INHIBITING PNEUMOCYSTIS CARINII PNEUMONIA, GIARDIA LAMBLIA AND CRYPTOSPORIDIUM PARVUM | GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) | 1997-09-03 | — | — | EP | disclosed |
| EP-0758453-A1 | METHOD OF FLUORESCENT DETECTION OF NUCLEIC ACIDS AND CYTOSKELETON ELEMENTS USING BIS-DICATIONIC ARYL FURANS | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1997-02-19 | — | — | EP | disclosed |
| US-5602172-A | USING A 2,5-DIPHENYLFURAN COMPOUND | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1997-02-11 | — | — | US | disclosed |
| US-5594138-A | MEDICAL DIAGNOSIS | GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION (US) | 1997-01-14 | — | — | US | disclosed |
| WO-1996040997-A1 | METHOD OF FLUORESCENT DETECTION OF NUCLEIC ACIDS AND CYTOSKELETON ELEMENTS USING BIS-DICATIONIC ARYL FURANS | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1996-12-19 | — | — | WO | disclosed |
| WO-1996015126-A1 | FURAN DERIVATIVES FOR INHIBITING PNEUMOCYSTIS CARINII PNEUMONIA, GIARDIA LAMBLIA AND CRYPTOSPORIDIUM PARVUM | GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) | 1996-05-23 | — | — | WO | disclosed |
| WO-1995030901-A1 | METHOD OF FLUORESCENT DETECTION OF NUCLEIC ACIDS AND CYTOSKELETON ELEMENTS USING BIS-DICATIONIC ARYL FURANS | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1995-11-16 | — | — | WO | disclosed |
| WO-1995030901-A1 | METHOD OF FLUORESCENT DETECTION OF NUCLEIC ACIDS AND CYTOSKELETON ELEMENTS USING BIS-DICATIONIC ARYL FURANS | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1995-11-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (21 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080194569-A1 | Phthalazinones | RB1, H1-3, H1-2 | TOP2A 705/4885TOP2B 529/4885ALDH1A1 1304/4885 |
| US-20080200451-A1 | Tetrahydroquinolines for Use as Modulators of the Mitotic Motor Protein Eg5 | KIF5A, KIF5C, KIF5B | TOP2A 486/4885TOP2B 449/4885ALDH1A1 3886/4885 |
| US-20120130147-A1 | METHODS FOR THE TREATMENT OF TUMORS WITH INDANE COMPOUNDS | TP53, IDH3A, IDH2 | TOP2A 23/4885TOP2B 27/4885ALDH1A1 347/4885 |
| US-20050080075-A1 | Formulations, conjugates, and combinations of drugs for the treatment of neoplasms | ABCB1, SLCO1B3, SLCO1B1 | TOP2A 59/4885TOP2B 104/4885ALDH1A1 571/4885 |
| US-20090118267-A1 | INDANES | IDH3A, CYP1A1, CCNT1 | TOP2A 358/4885TOP2B 403/4885ALDH1A1 180/4885 |
| US-20050137185-A1 | Combinations of drugs for the treatment of neoplasms | MKI67, DHFR, IL5 | TOP2A 112/4885TOP2B 173/4885ALDH1A1 412/4885 |
| US-20070099905-A1 | Combinations of drugs for the treatment of neoplasms | VHL, NRAS, MYC | TOP2A 63/4885TOP2B 43/4885ALDH1A1 662/4885 |
| US-20080234299-A1 | Quinazolinones | H1-3, NDUFS3, CCNT1 | TOP2A 276/4885TOP2B 349/4885ALDH1A1 1410/4885 |
| US-20100076012-A1 | TETRAHYDROQUINOLINE DERIVATIVES AND THE USE THEREOF FOR THE TREATMENT OF CANCER | RECQL, NDUFS3, SDHA | TOP2A 138/4885TOP2B 183/4885ALDH1A1 1759/4885 |
| US-20090030028-A1 | Tetrahydroquinolines | RECQL, QTRT1, NRAS | TOP2A 206/4885TOP2B 157/4885ALDH1A1 1192/4885 |
| US-20070203167-A1 | 2-(Hetero)-aryl substituted tetrahydrochinoline | NCOR1, CCNT2, NCOR2 | TOP2A 381/4885TOP2B 356/4885ALDH1A1 2222/4885 |
| US-20070208134-A1 | Anti-scarring drug combinations and use thereof | MMP1, COL2A1, COL1A1 | TOP2A 2285/4885TOP2B 2297/4885ALDH1A1 590/4885 |
| US-20050054708-A1 | Combinations of drugs for the treatment of neoplasms | TYMP, DPYD, DHFR | TOP2A 156/4885TOP2B 125/4885ALDH1A1 1543/4885 |
| US-20080194615-A1 | Antitumor agents; anticancer agents | RB1, TP53, CCNT1 | TOP2A 148/4885TOP2B 157/4885ALDH1A1 1144/4885 |
| US-20100022579-A1 | SUBSTITUTED TETRAHYDROQUINOLINES | RECQL, NDUFS3, TPD52L2 | TOP2A 122/4885TOP2B 170/4885ALDH1A1 1828/4885 |
| US-20070196421-A1 | Soft tissue implants and drug combination compositions, and use thereof | COL2A1, MMP1, FN1 | TOP2A 2035/4885TOP2B 1896/4885ALDH1A1 1623/4885 |
| US-20070219246-A1 | Dihydrobenzothiophenes | CCNT1, CCNT2, TPT1 | TOP2A 177/4885TOP2B 129/4885ALDH1A1 232/4885 |
| US-20070299043-A1 | Anti-scarring drug combinations and use thereof | MMP1, COL2A1, COL1A1 | TOP2A 2285/4885TOP2B 2297/4885ALDH1A1 590/4885 |
| US-20100120818-A1 | SUBSTITUTED TETRAHYDROPYRROLOQUINOLINES | TPD52L2, CCNT1, IDH2 | TOP2A 169/4885TOP2B 210/4885ALDH1A1 794/4885 |
| US-20080221118-A1 | treatment of tumors; 1,5-bis(4'-(N-hydroxyamidino)phenoxy)pentane; maintain cells in the G2/M cell cycle | CCNE1, CCNA1, CCNT1 | TOP2A 223/4885TOP2B 285/4885ALDH1A1 1306/4885 |
| US-20100022530-A1 | TETRAHYDROBENZOISOXAZOLE AND TETRAHYDROINDAZOLE DERIVATIVES AS MODULATORS OF THE MITOTIC MOTOR PROTEIN | CCNB3, TUBB3, CCNB1 | TOP2A 64/4885TOP2B 58/4885ALDH1A1 2977/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.