Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.37 |
| ▸ | ADORA2B | P29275 | 7/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 6/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CASP3 | P42574 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.33 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.33 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.33 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19810310 | 0.93 | ADORA2B (0.38) | ALDH1A1ADORA2BADORA2ATSHRLMNA | |
| SCHEMBL2670126 | 0.93 | ALDH1A1 (0.39) | ALDH1A1ADORA2BADORA2ATSHRLMNA | |
| SCHEMBL28394541 | 0.92 | ADORA2B (0.35) | ALDH1A1ADORA2BADORA2ATSHRLMNA | |
| SCHEMBL954434 | 0.91 | ABCB1 (0.41) | ALDH1A1ADORA2AABCB1HSD17B10KDM4E | |
| SCHEMBL20211769 | 0.91 | TSHR (0.36) | ALDH1A1ADORA2BADORA2ATSHRLMNA | |
| SCHEMBL28888591 | 0.91 | PSD (0.38) | ALDH1A1ADORA2BADORA2ATSHRLMNA | |
| SCHEMBL28391210 | 0.91 | PRNP (0.36) | ALDH1A1ADORA2BADORA2ATSHRLMNA | |
| SCHEMBL19810320 | 0.91 | LTB4R (0.36) | ALDH1A1ADORA2BADORA2ATSHRLMNA | |
| SCHEMBL19810212 | 0.91 | ALDH1A1 (0.38) | ALDH1A1ADORA2BADORA2ATSHRLMNA | |
| SCHEMBL64690 | 0.90 | ABCB1 (0.42) | ALDH1A1ADORA2AABCB1HSD17B10KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 68 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10669280-B2 | Coelenterazine analogues | PROMEGA CORPORATION (US) | 2020-06-02 | — | — | US | claimed |
| US-10428075-B2 | Coelenterazine analogues | PROMEGA CORPORATION (US) | 2019-10-01 | — | — | US | claimed |
| EP-3490991-A1 | COELENTERAZINE ANALOGUES | Promega Corporation (US) | 2019-06-05 | — | — | EP | claimed |
| US-20180334463-A1 | COELENTERAZINE ANALOGUES | JPMORGAN CHASE BANK, N.A., AS COLLATERAL AGENT | 2018-11-22 | — | — | US | claimed |
| US-10000500-B2 | Coelenterazine analogues | PROMEGA CORPORATION (US) | 2018-06-19 | — | — | US | claimed |
| WO-2018022865-A1 | COELENTERAZINE ANALOGUES | PROMEGA CORPORATION (US) | 2018-02-01 | — | — | WO | claimed |
| US-20180030059-A1 | COELENTERAZINE ANALOGUES | JPMORGAN CHASE BANK, N.A., AS COLLATERAL AGENT | 2018-02-01 | — | — | US | claimed |
| US-12612411-B1 | Imidazopyrazine derivatives, process for preparation thereof, and their uses as luciferins | INSTITUT PASTEUR (FR) | 2026-04-28 | — | — | US | disclosed |
| US-12576164-B2 | Imidazopyrazine derivatives, process for preparation thereof, and their uses as luciferins | INSTITUT PASTEUR (FR) | 2026-03-17 | — | — | US | disclosed |
| US-12570654-B2 | Nanoluc suicide substrates | PROMEGA CORPORATION (US) | 2026-03-10 | — | — | US | disclosed |
| EP-4608852-A1 | NOVEL FLUORESCENT AND BIOLUMINESCENT PROTEINS AND REPORTER SYSTEMS FOR RATIOMETRIC MEASUREMENT OF LUMINESCENCE | Urban, Jörg (DE) | 2025-09-03 | — | — | EP | disclosed |
| EP-3964501-B1 | IMIDAZOPYRAZINE DERIVATIVES, PROCESS FOR PREPARATION THEREOF, AND THEIR USES AS LUCIFERINS | PASTEUR INSTITUT (FR) | 2024-09-04 | — | — | EP | disclosed |
| US-20240197923-A1 | IMIDAZOPYRAZINE DERIVATIVES, PROCESS FOR PREPARATION THEREOF, AND THEIR USES AS LUCIFERINS | INSTITUT PASTEUR (FR) | 2024-06-20 | — | — | US | disclosed |
| US-8669103-B2 | Oplophorus-derived luciferases, novel coelenterazine substrates, and methods of use | PROMEGA CORPORATION (US) | 2014-03-11 | — | — | US | disclosed |
| US-8669103-B2 | Oplophorus-derived luciferases, novel coelenterazine substrates, and methods of use | PROMEGA CORPORATION (US) | 2014-03-11 | — | — | US | disclosed |
| US-20120174242-A1 | OPLOPHORUS-DERIVED LUCIFERASES, NOVEL COELENTERAZINE SUBSTRATES, AND METHODS OF USE | JPMORGAN CHASE BANK, N.A., AS COLLATERAL AGENT | 2012-07-05 | — | — | US | disclosed |
| US-20120174242-A1 | OPLOPHORUS-DERIVED LUCIFERASES, NOVEL COELENTERAZINE SUBSTRATES, AND METHODS OF USE | JPMORGAN CHASE BANK, N.A., AS COLLATERAL AGENT | 2012-07-05 | — | — | US | disclosed |
| WO-2012061529-A1 | NOVEL COELENTERAZINE SUBSTRATES AND METHODS OF USE | PROMEGA CORPORATION (US) | 2012-05-10 | — | — | WO | disclosed |
| US-20120117667-A1 | NOVEL COELENTERAZINE SUBSTRATES AND METHODS OF USE | JPMORGAN CHASE BANK, N.A., AS COLLATERAL AGENT | 2012-05-10 | — | — | US | disclosed |
| US-20120117667-A1 | NOVEL COELENTERAZINE SUBSTRATES AND METHODS OF USE | JPMORGAN CHASE BANK, N.A., AS COLLATERAL AGENT | 2012-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10000500-B2 | Coelenterazine analogues | GLB1, TCF7L2, SI | ALDH1A1 3416/4885ADORA2B 3223/4885ADORA2A 2012/4885 |
| US-12576164-B2 | Imidazopyrazine derivatives, process for preparation thereof, and their uses as luciferins | LUC7L2, HLCS, LANCL1 | ALDH1A1 659/4885ADORA2B 1588/4885ADORA2A 1256/4885 |
| US-20120117667-A1 | NOVEL COELENTERAZINE SUBSTRATES AND METHODS OF USE | RNGTT, UPF1, NSUN2 | ALDH1A1 4348/4885ADORA2B 4368/4885ADORA2A 3255/4885 |
| US-10669280-B2 | Coelenterazine analogues | GLB1, SI, TCF7L2 | ALDH1A1 3541/4885ADORA2B 3105/4885ADORA2A 1970/4885 |
| US-10428075-B2 | Coelenterazine analogues | GLB1, SI, TCF7L2 | ALDH1A1 3541/4885ADORA2B 3105/4885ADORA2A 1970/4885 |
| US-12612411-B1 | Imidazopyrazine derivatives, process for preparation thereof, and their uses as luciferins | LUC7L2, MRPL21, CRY1 | ALDH1A1 1484/4885ADORA2B 2182/4885ADORA2A 1556/4885 |
| US-20180030059-A1 | COELENTERAZINE ANALOGUES | GLB1, SI, TCF7L2 | ALDH1A1 3541/4885ADORA2B 3105/4885ADORA2A 1970/4885 |
| US-12570654-B2 | Nanoluc suicide substrates | NR3C1, LUC7L2, L3MBTL1 | ALDH1A1 1718/4885ADORA2B 3101/4885ADORA2A 2271/4885 |
| US-20240197923-A1 | IMIDAZOPYRAZINE DERIVATIVES, PROCESS FOR PREPARATION THEREOF, AND THEIR USES AS LUCIFERINS | NISCH, HLCS, CYP3A5 | ALDH1A1 972/4885ADORA2B 2895/4885ADORA2A 1755/4885 |
| US-20180334463-A1 | COELENTERAZINE ANALOGUES | GLB1, SI, TCF7L2 | ALDH1A1 3541/4885ADORA2B 3105/4885ADORA2A 1970/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.