Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Pyrrole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pyrrole SCHEMBL2260123 | 0.95 | — | — | |
| Pyrrole SCHEMBL21408148 | 0.95 | — | — | |
| Pyrrole SCHEMBL27678322 | 0.95 | — | — | |
| Pyrrole SCHEMBL29913186 | 0.95 | — | — | |
| Pyrrole SCHEMBL1256875 | 0.95 | — | — | |
| Pyrrole SCHEMBL1169316 | 0.95 | — | — | |
| Pyrrole SCHEMBL30294040 | 0.95 | — | — | |
| Pyrrole SCHEMBL19838558 | 0.90 | — | — | |
| Pyrrole SCHEMBL8836997 | 0.90 | — | — | |
| Pyrrole SCHEMBL9765084 | 0.90 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109303707-A | A kind of effective mouthwash and preparation method thereof for inhibiting oral peculiar smell | 罗爱莲 | 2019-02-05 | — | — | CN | claimed |
| CN-107998401-A | A kind of oral medicine preparation with slow release effect and preparation method thereof | 广州立白企业集团有限公司 | 2018-05-08 | — | — | CN | claimed |
| CN-107951733-A | The preparation and its application of Azulene sodium sulfonate and Cetylpyridinium Chloride compound mouthwash | 江苏大学 | 2018-04-24 | — | — | CN | claimed |
| CN-105007987-B | Oral care compositions and methods of making the same | 高露洁-棕榄公司 | 2017-11-10 | — | — | CN | claimed |
| CN-105793262-B | Two cycloalkyne derivatives and application thereof | 新加坡科技研究局 | 2019-09-03 | — | — | CN | disclosed |
| CN-106580836-B | A kind of oral care composition and its application containing plant factor | 广州薇美姿实业有限公司 | 2019-06-25 | — | — | CN | disclosed |
| CN-109674875-A | Oral ulcer nursing essence | 中山市怡口康科技有限公司 | 2019-04-26 | — | — | CN | disclosed |
| CN-109528625-A | Oral cavity composition and its application containing probiotics and antibacterial peptide | 扬州倍加洁日化有限公司 | 2019-03-29 | — | — | CN | disclosed |
| CN-108186639-B | A kind of pharmaceutical composition of SS 717 | 扬子江药业集团广州海瑞药业有限公司 | 2019-03-05 | — | — | CN | disclosed |
| CN-108939170-A | System and method for applying novel antimicrobial coating material in medical device | 贝克顿·迪金森公司 | 2018-12-07 | — | — | CN | disclosed |
| CN-104349671-B | Systems and methods for applying novel antimicrobial coating materials onto medical devices | 贝克顿·迪金森公司 | 2018-09-04 | — | — | CN | disclosed |
| CN-108186639-A | A kind of pharmaceutical composition of SS 717 | 扬子江药业集团广州海瑞药业有限公司 | 2018-06-22 | — | — | CN | disclosed |
| CN-106029668-A | Pyrrolo[3,2] pyrimidine derivatives as inducers of human interferon | 葛兰素史克知识产权第二有限公司 | 2016-10-12 | — | — | CN | disclosed |
| CN-105979933-A | Pharmaceutical preparation, method for the production thereof and use thereof | 因凡瑞斯有限公司 | 2016-09-28 | — | — | CN | disclosed |
| CN-105271176-A | Mesoporous carbon material and manufacturing method thereof | NANTONG LYUYE PILOT STUDIES TECHNOLOGY INST CO LTD | 2016-01-27 | — | — | CN | disclosed |
| US-20070191349-A1 | C8, c8' linked 5-oxo-1,2,3,11a-tetrahydro-5h-pyrrolo[2,1-c][1,4] benzodiazepine dimers with 1h-pyrrole-dicarboxylic acid amide linkers and oligomeric analogs therof as well as related compounds for the treatment of proliferative diseases | SPIROGEN LIMITED (GB) | 2007-08-16 | — | — | US | disclosed |
| EP-1720880-A1 | C8, C8' LINKED 5-OXO-1,2,3,11A-TETRAHYDRO-5H-PYRROLO[2,1-C][1,4]BENZODIAZEPINE DIMERS WITH 1H-PYRROLE-DICARBOXYLIC ACID AMIDE LINKERS AND OLIGOMERIC ANALOGS THEREOF AS WELL AS RELATED COMPOUNDS FOR THE TREATMENT OF PROLIFERATIVE DISEASES | Spirogen Limited (GB) | 2006-11-15 | — | — | EP | disclosed |
| WO-2005085250-A1 | C8, C8' LINKED 5-OXO-1,2,3,11A-TETRAHYDRO-5H-PYRROLO[2,1-C][1,4]BENZODIAZEPINE DIMERS WITH 1H-PYRROLE-DICARBOXYLIC ACID AMIDE LINKERS AND OLIGOMERIC ANALOGS THEROF AS WELL AS RELATED COMPOUNDS FOR THE TREATMENT OF PROLIFERATIVE DISEASES | SPIROGEN LIMITED (GB) | 2005-09-15 | — | — | WO | disclosed |
| CN-1042933-C | Benzoylguanidine, preparation of same and application as pharmaceutical and pharmaceutical containing same | HOECHST AG (DE) | 1999-04-14 | — | — | CN | disclosed |
| CN-1087900-A | Benzoyl guanidine, its preparation method and as medicine and contain the purposes of their medicament | HOECHST AG (DE) | 1994-06-15 | — | — | CN | disclosed |