Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Furan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Furan SCHEMBL8162355 | 1.00 | — | — | |
| Furan SCHEMBL8861365 | 1.00 | — | — | |
| Furan SCHEMBL27535099 | 1.00 | MAPK1 (0.89) | — | |
| Furan SCHEMBL28098190 | 0.95 | — | — | |
| Furan SCHEMBL8116777 | 0.95 | — | — | |
| Furan SCHEMBL419906 | 0.94 | — | — | |
| Furan SCHEMBL2053866 | 0.94 | MAPK1 (1.00) | — | |
| Furan SCHEMBL315 | 0.94 | — | — | |
| Furan SCHEMBL2455246 | 0.89 | — | — | |
| Benzene SCHEMBL4340876 | 0.89 | MAPK1 (0.89) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 52 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110229329-A | A kind of biomass-based furans polyamide continuous production device of high polymerization degree half and continuous producing method | 中国科学技术大学 | 2019-09-13 | — | — | CN | claimed |
| CN-105753822-B | A kind of benzofuran derivative, its preparation method and application | 华润赛科药业有限责任公司 | 2018-04-03 | — | — | CN | claimed |
| CN-105753822-A | Benzofuran derivative and preparation method and application thereof | 华润赛科药业有限责任公司 | 2016-07-13 | — | — | CN | claimed |
| CN-102070581-B | The preparation of 2-normal-butyl-3-(4-(the amino propoxy-of 3-di-n-butyl) benzoyl)-5-aminobenzofur | SHANGHAI INSTITUTE OF PHARMACEUTICAL INDUSTRY (CN) | 2015-11-25 | — | — | CN | claimed |
| CN-102070581-A | Preparation of 2-n-butyl-3-(4-(3-di-n-butylaminopropyl) benzoyl)-5-amino benzofuran | SHANGHAI INST PHARM INDUSTRY | 2011-05-25 | — | — | CN | claimed |
| CN-110052049-B | Equipment and method for producing acetyl n-propanol by continuous hydrogenation of 2-methyl furan | 山东一诺生物质材料有限公司 | 2024-02-09 | — | — | CN | disclosed |
| CN-112662126-B | Continuous fiber reinforced poly-hexahydrotriazine resin-based heat-conducting composite material and preparation method thereof | 华南理工大学 | 2022-11-18 | — | — | CN | disclosed |
| CN-114729354-A | Small RNA medicine for preventing and treating inflammatory related diseases and combination thereof | 中国医学科学院基础医学研究所 | 2022-07-08 | — | — | CN | disclosed |
| US-11283110-B2 | Electrolyte composition and metal-ion battery employing the same | INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE (TW) | 2022-03-22 | — | — | US | disclosed |
| CN-111384445-A | Electrolyte composition and metal ion battery comprising same | 财团法人工业技术研究院 | 2020-07-07 | — | — | CN | disclosed |
| CN-110229329-A | A kind of biomass-based furans polyamide continuous production device of high polymerization degree half and continuous producing method | 中国科学技术大学 | 2019-09-13 | — | — | CN | disclosed |
| CN-110229329-A | A kind of biomass-based furans polyamide continuous production device of high polymerization degree half and continuous producing method | 中国科学技术大学 | 2019-09-13 | — | — | CN | disclosed |
| EP-0927177-A1 | NOVEL BENZOTHIOPHENE DERIVATIVES, THEIR PREPARATION AND USE AS UROKINASE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1999-07-07 | — | — | EP | disclosed |
| CN-1189493-A | New Substituted biphenyl or phenylpyridine compounds, process for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 1998-08-05 | — | — | CN | disclosed |
| WO-1998011089-A1 | NOVEL BENZOTHIOPHENE DERIVATIVES, THEIR PREPARATION AND USE AS UROKINASE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-03-19 | — | — | WO | disclosed |
| CN-1154697-A | Oxygen-contg. heterocyclic compound | KYOWA HAKKO KOGYO KK (JP) | 1997-07-16 | — | — | CN | disclosed |
| EP-0757682-A1 | BENZOFURAN DERIVATIVES USEFUL AS INHIBITORS OF BONE RESORPTION | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-02-12 | — | — | EP | disclosed |
| CN-1032135-C | 2,3-dihydro-5-oxy-4,6,7-trimethylbenzofurans 2-(RS)- derivatives with properties of mucus-adjustment and antiischemia | FOSCAMA BIOMED CHIM FARMA (IT) | 1996-06-26 | — | — | CN | disclosed |
| CN-1049499-A | Have that mucus is regulated and anti-ischemia character 2,3-dihydro-5-oxygen-4,6,2-(the RS)-derivative of 7-trimethylammonium benzo furans and as the purposes of anti-oxidant medicament | FOSCAMA BIOMED CHIM FARMA (IT) | 1991-02-27 | — | — | CN | disclosed |
| US-4011067-A | FILTER MEDIUM LAYERED BETWEEN SUPPORTING LAYERS | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1977-03-08 | — | — | US | disclosed |