Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hno. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hno SCHEMBL3036045 | 0.89 | — | — | |
| Hno SCHEMBL9342219 | 0.89 | — | — | |
| Hno SCHEMBL168461 | 0.89 | — | — | |
| Hno SCHEMBL9340257 | 0.89 | — | — | |
| Hno SCHEMBL28136677 | 0.80 | — | — | |
| Hno SCHEMBL27460527 | 0.80 | — | — | |
| Hno SCHEMBL2311435 | 0.80 | — | — | |
| Hno SCHEMBL14889227 | 0.78 | — | — | |
| Hno SCHEMBL7785053 | 0.78 | — | — | |
| Hno SCHEMBL8928095 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112142127-A | Method for preparing ruthenium nitrosyl nitrate solution | 中国船舶重工集团公司第七一八研究所 | 2020-12-29 | — | — | CN | disclosed |
| EP-0830161-B1 | NITRIC OXIDE-RELEASING NITROSO COMPOSITIONS AND METHODS AND INTRAVASCULAR DEVICES FOR USING THEM TO PREVENT RESTENOSIS | NOVOVASCULAR INC (US) | 2004-07-28 | — | — | EP | disclosed |
| EP-0975274-A4 | INHIBITION OF BLOOD PLATELET AGGREGATION IN BLOOD EXPOSED TO A FOREIGN BODY BY A POLYMER COATING ON THE SURFACE THEREOF CONTAINING A NITRIC OXIDE-RELEASING NITROSYL-CONTAINING ORGANOMETALLIC COMPOUND AND FOREIGN BODIES THUS COATED | NOVO VASC L L C (US) | 2004-05-19 | — | — | EP | disclosed |
| EP-0700378-B1 | COMPOUNDS WHICH RELEASE NITRIC OXIDE | UNIV CALIFORNIA (US) | 2000-12-20 | — | — | EP | disclosed |
| EP-0830161-A4 | NITRIC OXIDE-RELEASING NITROSO COMPOSITIONS AND METHODS AND INTRAVASCULAR DEVICES FOR USING THEM TO PREVENT RESTENOSIS | NOVOVASC LLC (US) | 2000-08-02 | — | — | EP | disclosed |
| EP-0975274-A2 | INHIBITION OF BLOOD PLATELET AGGREGATION IN BLOOD EXPOSED TO A FOREIGN BODY BY A POLYMER COATING ON THE SURFACE THEREOF CONTAINING A NITRIC OXIDE-RELEASING NITROSYL-CONTAINING ORGANOMETALLIC COMPOUND AND FOREIGN BODIES THUS COATED | Novo Vasc, L.L.C. (US) | 2000-02-02 | — | — | EP | disclosed |
| US-5797887-A | Medical device with a surface adapted for exposure to a blood stream which is coated with a polymer containing a nitrosyl-containing organo-metallic compound which releases nitric oxide from the coating to mediate platelet aggregation | NOVOVASC LLC (US) | 1998-08-25 | — | — | US | disclosed |
| EP-0830161-A1 | NITRIC OXIDE-RELEASING NITROSO COMPOSITIONS AND METHODS AND INTRAVASCULAR DEVICES FOR USING THEM TO PREVENT RESTENOSIS | Nitrosci Pharmaceuticals, LLC (US) | 1998-03-25 | — | — | EP | disclosed |
| WO-1998008482-A2 | POLYMERIC COATING FOR A SURFACE EXPOSED TO BLOOD | NOVO VASC, L.L.C. (US) | 1998-03-05 | — | — | WO | disclosed |
| US-5665077-A | Nitric oxide-releasing nitroso compositions and methods and intravascular devices for using them to prevent restenosis | NITROSCI PHARMACEUTICALS LLC (US) | 1997-09-09 | — | — | US | disclosed |
| WO-1996033757-A1 | NITRIC OXIDE-RELEASING NITROSO COMPOSITIONS AND METHODS AND INTRAVASCULAR DEVICES FOR USING THEM TO PREVENT RESTENOSIS | NITROSCI PHARMACEUTICALS, LLC (US) | 1996-10-31 | — | — | WO | disclosed |
| EP-0700378-A1 | COMPOUNDS WHICH RELEASE NITRIC OXIDE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1996-03-13 | — | — | EP | disclosed |
| EP-0700378-A4 | COMPOUNDS WHICH RELEASE NITRIC OXIDE | UNIV CALIFORNIA (US) | 1996-01-22 | — | — | EP | disclosed |
| US-5374710-A | Compounds which release nitric oxide upon illumination | REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1994-12-20 | — | — | US | disclosed |
| WO-1994027957-A1 | COMPOUNDS WHICH RELEASE NITRIC OXIDE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1994-12-08 | — | — | WO | disclosed |