Hydrochloric Acid

Hydrochloric Acid

SCHEMBL6648767

Cl.O=C(O)c1ccccc1Oc1ccccc1

nearest known ligand 0.69

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ESR1 known ✓ P03372 1/20 0.55
ITGB3 known ✓ P05106 1/20 0.55
ITGA2B known ✓ P08514 1/20 0.55
PTGS1 known ✓ P23219 1/20 0.55
PTGS2 known ✓ P35354 1/20 0.55
PDE3A known ✓ Q14432 1/20 0.53
CTNNB1 P35222 1/20 0.69
HTT P42858 2/20 0.61
ALDH1A1 P00352 7/20 0.59
SMN1; SMN2 Q16637 1/20 0.56
HSD17B10 Q99714 6/20 0.55
KDM4E B2RXH2 6/20 0.55
HPGD P15428 5/20 0.55
TSHR P16473 2/20 0.55
HMGB1 P09429 1/20 0.55
GGT1 P19440 1/20 0.55
BLM P54132 1/20 0.55
NAPRT Q6XQN6 1/20 0.55
TDP1 Q9NUW8 1/20 0.55
MAPT P10636 3/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1798 0.98 CTNNB1 (0.71) CTNNB1HTTALDH1A1SMN1; SMN2HSD17B10
SCHEMBL4129945 0.96 CTNNB1 (0.69) CTNNB1HTTALDH1A1SMN1; SMN2HSD17B10
Bicarbonate SCHEMBL29943548 0.96 CTNNB1 (0.69) CTNNB1HTTALDH1A1SMN1; SMN2HSD17B10
SCHEMBL17888702 0.96 CTNNB1 (0.69) CTNNB1HTTALDH1A1SMN1; SMN2HSD17B10
SCHEMBL8496446 0.96 CTNNB1 (0.69) CTNNB1HTTALDH1A1SMN1; SMN2HSD17B10
SCHEMBL11875755 0.96 CTNNB1 (0.69) CTNNB1HTTALDH1A1SMN1; SMN2HSD17B10
Bicarbonate SCHEMBL236889 0.96 CTNNB1 (0.69) CTNNB1HTTALDH1A1SMN1; SMN2HSD17B10
SCHEMBL11407865 0.96 CTNNB1 (0.69) CTNNB1HTTALDH1A1SMN1; SMN2HSD17B10
Bicarbonate SCHEMBL21517637 0.96 CTNNB1 (0.69) CTNNB1HTTALDH1A1SMN1; SMN2HSD17B10
SCHEMBL1537710 0.94 HTT (0.70) CTNNB1HTTALDH1A1SMN1; SMN2HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0030676-B1 DERIVATIVES OF PHENOXYBENZOIC ACID, PROCESS FOR THEIR PREPARATION AND THEIR USE AS HERBICIDES AND AS PLANT GROWTH REGULATORS BAYER AG (DE) 1984-02-08 EP claimed
US-20180282336-A1 Active Acrylamides SANDOZ AG (CH) 2018-10-04 US disclosed
US-20170327504-A1 Synthesis of Substituted 1H-Pyrazolo[3,4-D]Pyrimidines SANDOZ AG (CH) 2017-11-16 US disclosed
EP-3212624-A1 SYNTHESIS OF SUBSTITUTED 1H-PYRAZOLO[3,4-D]PYRIMIDINES Sandoz AG (CH) 2017-09-06 EP disclosed
EP-3212653-A2 ACTIVE ACRYLAMIDES Sandoz AG (CH) 2017-09-06 EP disclosed
WO-2016066726-A2 ACTIVE ACRYLAMIDES SANDOZ AG (CH) 2016-05-06 WO disclosed
WO-2016066673-A1 SYNTHESIS OF SUBSTITUTED 1H-PYRAZOLO[3,4-D]PYRIMIDINES SANDOZ AG (CH) 2016-05-06 WO disclosed
EP-0904262-B1 CONFORMATIONALLY RESTRICTED AROMATIC INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND METHOD BRISTOL MYERS SQUIBB CO (US) 2004-04-21 EP disclosed
US-6472414-B1 Conformationally restricted aromatic inhibitors of microsomal triglyceride transfer protein and method BRISTOL-MYERS SQUIBB COMPANY 2002-10-29 US disclosed
EP-0904262-A4 CONFORMATIONALLY RESTRICTED AROMATIC INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND METHOD BRISTOL MYERS SQUIBB CO (US) 2000-10-04 EP disclosed
US-5827875-A PYRROLIDINE DERIVATIVES; ANTIATHEROSCLEROSIS AGENTS BRISTOL-MYERS SQUIBB COMPANY (US) 1998-10-27 US disclosed
US-5760246-A ANTILIPEMIC AGENTS, ANTICHOLESTEROL AGENTS BRISTOL-MYERS SQUIBB COMPANY 1998-06-02 US disclosed
WO-1997043257-A1 INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND METHOD BRISTOL-MYERS SQUIBB COMPANY (US) 1997-11-20 WO disclosed
WO-1997026240-A1 CONFORMATIONALLY RESTRICTED AROMATIC INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND METHOD BRISTOL-MYERS SQUIBB COMPANY (US) 1997-07-24 WO disclosed
US-4889946-A Phenoxybenzoic acid compounds and herbicidal and plant growth regulant compositions BAYER AKTIENGESELLSCHAFT (DE) 1989-12-26 US disclosed
US-4723985-A Herbicidal phenoxybenzoic acid derivatives BAYER AKTIENGESELLSCHAFT (DE) 1988-02-09 US disclosed
US-4540827-A Phenoxybenzene derivatives BAYER AKTIENGESELLSCHAFT (DE) 1985-09-10 US disclosed
US-4482736-A Herbicidally active substituted phenoxycinnamic acid derivatives BAYER AKTIENGESELLSCHAFT (DE) 1984-11-13 US disclosed
US-4435208-A Herbicidally active substituted phenoxycinnamic acid derivatives BAYER AKTIENGESELLSCHAFT (DE) 1984-03-06 US disclosed
EP-0070990-A2 Substituted phenoxybenzoic acid-azolylalkyl esters, process for their preparation and their herbicidal application BAYER AG (DE) 1983-02-09 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180282336-A1 Active Acrylamides BTK, SYK, LYN ESR1 1694/4885ITGB3 1304/4885ITGA2B 1563/4885
US-20170327504-A1 Synthesis of Substituted 1H-Pyrazolo[3,4-D]Pyrimidines BTK, ABL1, SYK ESR1 2312/4885ITGB3 3467/4885ITGA2B 4061/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.