Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Adenine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 known ✓ | P35462 | 1/20 | 0.96 |
| ▸ | HSP90AA1 known ✓ | P07900 | 1/20 | 0.50 |
| ▸ | HSP90AB1 known ✓ | P08238 | 1/20 | 0.50 |
| ▸ | PRKCD known ✓ | Q05655 | 1/20 | 0.50 |
| ▸ | PI4KA | P42356 | 2/20 | 1.00 |
| ▸ | PI4K2B | Q8TCG2 | 2/20 | 1.00 |
| ▸ | PI4K2A | Q9BTU6 | 2/20 | 1.00 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 1.00 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.96 |
| ▸ | LMNA | P02545 | 2/20 | 0.96 |
| ▸ | XDH | P47989 | 1/20 | 0.96 |
| ▸ | PDPK1 | O15530 | 4/20 | 0.53 |
| ▸ | GDA | Q9Y2T3 | 1/20 | 0.53 |
| ▸ | G6PD | P11413 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.50 |
| ▸ | AURKA | O14965 | 1/20 | 0.50 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.50 |
| ▸ | PRKACA | P17612 | 1/20 | 0.50 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Adenine SCHEMBL7204511 | 1.00 | PI4KA (1.00) | PI4KAPI4K2BPI4K2API4KBLRRK2 | |
| Adenine SCHEMBL11798396 | 1.00 | PI4KA (1.00) | PI4KAPI4K2BPI4K2API4KBLRRK2 | |
| Adenine SCHEMBL27828322 | 0.98 | PI4KA (0.96) | PI4KAPI4K2BPI4K2API4KBLRRK2 | |
| Adenine SCHEMBL6475049 | 0.98 | PI4KA (0.96) | PI4KAPI4K2BPI4K2API4KBLRRK2 | |
| Adenine SCHEMBL8111 | 0.98 | PI4KA (1.00) | PI4KAPI4K2BPI4K2API4KBLRRK2 | |
| Adenine SCHEMBL29982697 | 0.98 | PI4KA (1.00) | PI4KAPI4K2BPI4K2API4KBLRRK2 | |
| Adenine SCHEMBL29355156 | 0.98 | PI4KA (1.00) | PI4KAPI4K2BPI4K2API4KBLRRK2 | |
| Adenine SCHEMBL3414606 | 0.98 | PI4KA (1.00) | PI4KAPI4K2BPI4K2API4KBLRRK2 | |
| Adenine SCHEMBL1331751 | 0.98 | PI4KA (1.00) | PI4KAPI4K2BPI4K2API4KBLRRK2 | |
| Adenine SCHEMBL29466915 | 0.98 | PI4KA (1.00) | PI4KAPI4K2BPI4K2API4KBLRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 309 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118786984-A | Stem cell cold storage preservation solution and preparation method and application thereof | 北京全式金生物技术股份有限公司 | 2024-10-18 | — | — | CN | claimed |
| EP-4070869-B1 | METHOD OF ANALYZING A MONOMER OF A RECOMBINANT EXTRACELLULAR MATRIX PROTEIN BY SIZE EXCLUSION CHROMATOGRAPHY | HAPLNSCIENCE INC (KR) | 2024-01-31 | — | — | EP | claimed |
| EP-4070869-A1 | METHOD OF ANALYZING A MONOMER OF A RECOMBINANT EXTRACELLULAR MATRIX PROTEIN BY SIZE EXCLUSION CHROMATOGRAPHY | HAPLNSCIENCE INC. (KR) | 2022-10-12 | — | — | EP | claimed |
| US-20220290201-A1 | MEDIUM COMPOSITION FOR CULTURING ANIMAL CELLS FOR PRODUCING RECOMBINANT EXTRACELLULAR MATRIX PROTEIN AND METHOD OF USING THE SAME | Haplnscience inc. (KR) | 2022-09-15 | — | — | US | claimed |
| CN-115003793-A | Culture medium composition for culturing animal cells to produce recombinant extracellular matrix proteins and methods of using same | 哈普赛安思有限公司 | 2022-09-02 | — | — | CN | claimed |
| EP-4041863-A1 | MEDIUM COMPOSITION FOR CULTURING ANIMAL CELLS FOR PRODUCING RECOMBINANT EXTRACELLULAR MATRIX PROTEIN AND METHOD OF USING THE SAME | HAPLNSCIENCE INC. (KR) | 2022-08-17 | — | — | EP | claimed |
| WO-2022146036-A1 | MEDIUM COMPOSITION FOR CULTURING ANIMAL CELLS FOR PRODUCING RECOMBINANT EXTRACELLULAR MATRIX PROTEIN AND METHOD OF USING THE SAME | Haplnscience inc. (KR) | 2022-07-07 | — | — | WO | claimed |
| CN-111686307-B | Preparation method of biological conductive nanofiber tissue engineering scaffold | 南京理工大学 | 2022-05-13 | — | — | CN | claimed |
| CN-111686307-A | Preparation method of biological conductive nanofiber tissue engineering scaffold | 南京理工大学 | 2020-09-22 | — | — | CN | claimed |
| CN-111269876-A | Method for in vitro fertilization and embryo culture by in vivo collection of bovine oocytes | 天津博裕力牧科技有限公司 | 2020-06-12 | — | — | CN | claimed |
| US-5840705-A | CONTAINING NUCLEOTIDE, NUCLEOSIDE AND/OR NUCLEIC ACID-DERIVED BASE AS ENZYME INHIBITOR; TREATING DIABETES, OBESITY | THE HOKUREN FEDERATION OF AGRICULTURAL COOPERATIVES (JP) | 1998-11-24 | — | — | US | claimed |
| EP-0513361-B1 | METHOD OF ASSAYING ENDOTOXIN | SEIKAGAKU KOGYO CO LTD (JP) | 1996-12-04 | — | — | EP | claimed |
| EP-0738475-A1 | Alpha-glucosidase inhibitor, composition principally comprising sugar and containing the same, sweetener, food and feed | THE HOKUREN FEDERATION OF AGRICULTURAL COOPERATIVES (JP) | 1996-10-23 | — | — | EP | claimed |
| WO-1995013763-A1 | DEVICE, SYSTEM, PROCEDURE AND USE THEREOF FOR TEMPORARY SPLINTING OF THE URINARY TRACT | ANGIOMED AKTIENGESELLSCHAFT (DE) | 1995-05-26 | — | — | WO | claimed |
| US-5378610-A | Surfactants, incubation and analyzing for endotoxins | SEIKAGAKU KOGYO KABUSHIKI KAISHA (SEIKAGAKU CORPORATION) (JP) | 1995-01-03 | — | — | US | claimed |
| EP-0513361-A1 | METHOD OF ASSAYING ENDOTOXIN | SEIKAGAKU KOGYO KABUSHIKI KAISHA (SEIKAGAKU CORPORATION) (JP) | 1992-11-19 | — | — | EP | claimed |
| EP-0301250-A1 | Aqueous solution for the suspension and storage of cells, in particular erythrocytes | BIOTEST PHARMA GMBH (DE) | 1989-02-01 | — | — | EP | claimed |
| EP-0100419-B1 | AQUEOUS SOLUTION FOR SUSPENDING AND STORING CELLS, PARTICULARLY ERYTHROCYTES | Biotest Aktiengesellschaft (DE) | 1987-09-02 | — | — | EP | claimed |
| US-4572899-A | SODIUM CHLORIDE, GLUCOSE OR FRUCTOSE, ADENINE, GUANOSINE, PHOSPHATE, SORBITOL OR XYLITOL | BIOTEST-SERUM-INSTITUT GMBH (DE) | 1986-02-25 | — | — | US | claimed |
| EP-0100419-A2 | Aqueous solution for suspending and storing cells, particularly erythrocytes | Biotest Aktiengesellschaft (DE) | 1984-02-15 | — | — | EP | claimed |