Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 2/20 | 0.46 |
| ▸ | CYP17A1 | P05093 | 7/20 | 0.45 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.45 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.44 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.44 |
| ▸ | TTK | P33981 | 1/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | MMP3 | P08254 | 1/20 | 0.42 |
| ▸ | MMP12 | P39900 | 1/20 | 0.42 |
| ▸ | MMP13 | P45452 | 1/20 | 0.42 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.42 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.41 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12416702 | 0.80 | ALDH1A1 (0.48) | MEN1KMT2AADAMTS4MMP2MMP3 | |
| SCHEMBL6878332 | 0.80 | PGR (0.49) | MMP2MMP3MMP13CHEK1 | |
| SCHEMBL6791144 | 0.76 | CYP17A1 (0.54) | CYP17A1CYP11B1CYP11B2CRBNDDB1 | |
| SCHEMBL6878178 | 0.74 | MMP13 (0.58) | MEN1KMT2AADAMTS4MMP2MMP3 | |
| SCHEMBL2874194 | 0.73 | GRIA2 (0.52) | CYP17A1CYP11B1CYP11B2CRBNDDB1 | |
| SCHEMBL3675252 | 0.72 | RAB9A (0.65) | CYP17A1CYP11B1CYP11B2MEN1KMT2A | |
| SCHEMBL6876082 | 0.72 | MMP13 (0.47) | MEN1KMT2AADAMTS4MMP2MMP3 | |
| SCHEMBL6840055 | 0.71 | SMN1; SMN2 (0.40) | MEN1KMT2AADAMTS4MMP2MMP3 | |
| SCHEMBL4450492 | 0.70 | ENPP2 (0.56) | FYNCYP17A1CYP11B1CYP11B2MEN1 | |
| SCHEMBL8577619 | 0.70 | SMN1; SMN2 (0.70) | CYP17A1CYP11B1CYP11B2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040147573-A1 | Metalloproteinase inhibitors | ASTRAZENECA AB (SE) | 2004-07-29 | — | — | US | disclosed |
| US-20040106659-A1 | Metalloproteinase inhibitors | ASTRAZENECA AB (SE) | 2004-06-03 | — | — | US | disclosed |
| EP-1370536-A1 | METALLOPROTEINASE INHIBITORS | AstraZeneca AB (SE) | 2003-12-17 | — | — | EP | disclosed |
| WO-2002074750-A1 | METALLOPROTEINASE INHIBITORS | ASTRAZENECA AB (SE) | 2002-09-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040106659-A1 | Metalloproteinase inhibitors | MMP9, TIMP3, MMP11 | FYN 4159/4885CYP17A1 151/4885CYP11B1 401/4885 |
| US-20040147573-A1 | Metalloproteinase inhibitors | MMP12, MMP7, MMP10 | FYN 3991/4885CYP17A1 110/4885CYP11B1 139/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.