Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5544397 | 1.00 | TRIM24 (0.39) | — | |
| Hydrochloric Acid SCHEMBL8498788 | 0.97 | TRIM24 (0.37) | — | |
| Hydrochloric Acid SCHEMBL2245157 | 0.97 | — | — | |
| Water SCHEMBL757242 | 0.97 | — | — | |
| Hydrochloric Acid SCHEMBL158082 | 0.97 | — | — | |
| Bromide SCHEMBL30521957 | 0.93 | TRIM24 (0.39) | — | |
| Methane SCHEMBL691438 | 0.93 | — | — | |
| Bromide SCHEMBL22283857 | 0.93 | — | — | |
| SCHEMBL6529739 | 0.93 | TRIM24 (0.44) | — | |
| SCHEMBL83334 | 0.93 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1945 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112105608-B | Process for the preparation of (1- (3-fluoro-2- (trifluoromethyl) isonicotinyl) piperidin-4-one | 因赛特公司 | 2023-07-14 | — | — | CN | claimed |
| CN-114524799-B | HDAC inhibitor and preparation method and application thereof | 沈阳药科大学 | 2023-05-26 | — | — | CN | claimed |
| CN-115109391-B | Preparation method and application of polyarylpiperidine anion-exchange membrane with quaternary ammonium side chain | 宿迁时代储能科技有限公司 | 2023-05-05 | — | — | CN | claimed |
| CN-113024554-B | Preparation method of rumepilone intermediate | 上海法默生物科技有限公司 | 2023-03-14 | — | — | CN | claimed |
| US-11512064-B2 | Salts of an LSD1 inhibitor and processes for preparing the same | INCYTE CORPORATION (US) | 2022-11-29 | — | — | US | claimed |
| CN-115109391-A | Preparation method and application of polyarylpiperidine anion exchange membrane with quaternary ammonium side chain | 宿迁时代储能科技有限公司 | 2022-09-27 | — | — | CN | claimed |
| CN-114524799-A | HDAC inhibitor and preparation method and application thereof | 沈阳药科大学 | 2022-05-24 | — | — | CN | claimed |
| US-20210300891-A1 | SALTS OF AN LSD1 INHIBITOR AND PROCESSES FOR PREPARING THE SAME | INCYTE CORPORATION | 2021-09-30 | — | — | US | claimed |
| CN-109411788-B | Aza spiro cation loaded polybiphenyl basic film and preparation method thereof | 北京化工大学 | 2021-07-13 | — | — | CN | claimed |
| CN-113024554-A | Preparation method of rumepilone intermediate | 上海法默生物科技有限公司 | 2021-06-25 | — | — | CN | claimed |
| CN-1642943-A | Synthesis of piperidine and piperazine compounds as CCR5 antagonists | SCHERING CORP (US) | 2005-07-20 | — | — | CN | claimed |
| EP-1490352-A1 | SYNTHESIS OF PIPERIDINE AND PIPERAZINE COMPOUNDS AS CCR5 ANTAGONISTS | SCHERING CORPORATION (US) | 2004-12-29 | — | — | EP | claimed |
| EP-1260511-B1 | Process for the preparation of 5-chloro-1-(4-fluorophenyl)-3-(1,2,3,6-tetrahydropyridin-4-yl)indole and method of manufacturing sertindole | LUNDBECK & CO AS H (DK) | 2004-12-29 | — | — | EP | claimed |
| WO-2004058264-A1 | COMPOUND LIBRARIES OF 2H-SPIRO (ISOQUINOLINE-1, -PIPERIDINE DERIVATIVES AND RELATED COMPOUNDS FOR TARGETTING COMPOUNDS CAPABLE OF BINDING TO THE G-PROTEIN RECEPTOR | BIOFOCUS PLC (GB) | 2004-07-15 | — | — | WO | claimed |
| US-20040024217-A1 | Synthesis of piperidine and piperazine compounds as CCR5 antagonists | SCHERING CORPORATION | 2004-02-05 | — | — | US | claimed |
| WO-2003084950-A1 | SYNTHESIS OF PIPERIDINE AND PIPERAZINE COMPOUNDS AS CCR5 ANTAGONISTS | SCHERING CORPORATION (US) | 2003-10-16 | — | — | WO | claimed |
| EP-1260511-A1 | Process for the preparation of 5-chloro-1-(4-fluorophenyl)-3-(1,2,3,6-tetrahydropyridin-4-yl)indole and method of manufacturing sertindole | H. Lundbeck A/S (DK) | 2002-11-27 | — | — | EP | claimed |
| US-6335463-B1 | Method of manufacturing sertindole | H. LUNDBECK A/S (DK) | 2002-01-01 | — | — | US | claimed |
| EP-0983264-A1 | METHOD OF MANUFACTURING SERTINDOLE | H. LUNDBECK A/S (DK) | 2000-03-08 | — | — | EP | claimed |
| WO-1998051685-A1 | METHOD OF MANUFACTURING SERTINDOLE | H. LUNDBECK A/S (DK) | 1998-11-19 | — | — | WO | claimed |